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5 October 2023 Colorimetric metasurfaces for next-generation, on-chip imaging of tissue microstructure
Lisa Poulikakos, Paula Kirya, Samantha Bordy, Justin Hochberg, Jonathan Pokorski, Omonigho Aisagbonhi
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Proceedings Volume PC12654, Enhanced Spectroscopies and Nanoimaging 2023; PC1265408 (2023) https://doi.org/10.1117/12.2677922
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States
Abstract
The origin and progression of a variety of leading health challenges, encompassing Alzheimer’s disease, heart disease, fibrosis and cancer, are directly linked to changes in the presence and orientation of fibrous matter in biological tissue. Fibrous biological tissue exhibits distinct anisotropic optical properties, which can be leveraged for selective imaging. However, these naturally occurring light-matter interactions are inherently weak, posing barriers to their visualization. Here, we leverage anisotropic, colorimetric metasurfaces to selectively visualize disease-relevant fiber density and orientation in biological tissue. We then investigate versatile fiber-affecting diseases where metasurfaces hold great potential to achieve rapid, precise and low-cost tissue diagnostics.
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Lisa Poulikakos, Paula Kirya, Samantha Bordy, Justin Hochberg, Jonathan Pokorski, and Omonigho Aisagbonhi "Colorimetric metasurfaces for next-generation, on-chip imaging of tissue microstructure", Proc. SPIE PC12654, Enhanced Spectroscopies and Nanoimaging 2023, PC1265408 (5 October 2023); https://doi.org/10.1117/12.2677922
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KEYWORDS
Tissues
Biological imaging
Diagnostics
Visualization
Cancer
Cardiovascular disorders
Diseases and disorders
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