Multiple scattering of light in biological tissues rapidly scrambles polarization, so polarimetric biomedicine is challenging. Nevertheless, there are ways to mitigate these and other tissue-specific challenges to extract useful biophysics via both Stokes and Mueller matrix analyses. In this talk, I will highlight our ongoing studies of tissue birefringence in histology-like thin-sample transmission geometry (potential applications for breast and colorectal cancer), and in thick-tissue reflection geometry (potential applications for intraoperative surgical guidance). Enabling technology approaches, preclinical results, and selected patient studies will be highlighted
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