Molecular imaging and photoimmunotherapy of oral cancers using an EGFR targeted antibody conjugate

Mohammad A. Saad; Harrison J. Roberts; Isabella Feng; Kaylee Mai; Zhiming Mai; Srivalleesha Mallidi; Tayyaba Hasan

doi:10.1117/12.3000573

13 March 2024 Molecular imaging and photoimmunotherapy of oral cancers using an EGFR targeted antibody conjugate

Mohammad A. Saad, Harrison J. Roberts, Isabella Feng, Kaylee Mai, Zhiming Mai, Srivalleesha Mallidi, Tayyaba Hasan

Author Affiliations +

Proceedings Volume PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024; (2024) https://doi.org/10.1117/12.3000573
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

In this study, we study the influence of dye to antibody ratio on the imaging and therapeutic performance of an EGFR-targeted dual function conjugate. We further demonstrate the efficacy of the conjugate in identifying tumor depth to guide surgical resections and the ability to eliminate residual microscopic disease through photoimmunotherapy, in a single intra-operative setting.

Conference Presentation

Citation Download Citation

Mohammad A. Saad, Harrison J. Roberts, Isabella Feng, Kaylee Mai, Zhiming Mai, Srivalleesha Mallidi, and Tayyaba Hasan "Molecular imaging and photoimmunotherapy of oral cancers using an EGFR targeted antibody conjugate", Proc. SPIE PC12818, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2024, (13 March 2024); https://doi.org/10.1117/12.3000573

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