Tatiana Soldati,1 Sofi M. Vassileva,2 Margherita Vaselli,1 Kirsten A. Kalverda,2 Pieta P. C. Wijsman,2 Jouke T. Annema,2 Peter I. Bonta,2 Johannes F. de Boer1
1Vrije Univ. Amsterdam (Netherlands) 2Amsterdam Univ. Medical Ctr. (Netherlands)
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No diagnostic method is currently available to visualize and measure the airway smooth muscle (ASM) within a living patient. Endoscopic Polarization Sensitive Optical Coherence Tomography (PS-OCT) might enable quantification of ASM mass in vivo, by assessing tissue birefringence. We performed in vivo PS-OCT on patients (n=17) with airway diseases (asthma and interstitial lung disease) and one healthy volunteer. An in-house built distal scanning catheter (1.35 mm) was used to circumferentially scan the airways at 52 fps B-scan rate. We demonstrated PS-OCT to be a minimally invasive technique to assess ASM thickness in diseased airways relative to healthy subjects.
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Tatiana Soldati, Sofi M. Vassileva, Margherita Vaselli, Kirsten A. Kalverda, Pieta P. C. Wijsman, Jouke T. Annema, Peter I. Bonta, Johannes F. de Boer, "Endoscopic polarization sensitive optical coherence tomography for airway smooth muscle quantification in healthy and diseased airways," Proc. SPIE PC12820, Endoscopic Microscopy XIX, PC1282005 (13 March 2024); https://doi.org/10.1117/12.3002931