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13 March 2024 Protease-activated probes for real-time ratiometric imaging of solid tumors
Matthew Bogyo
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Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC128250K (2024) https://doi.org/10.1117/12.3009175
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
In this presentation, I will describe our efforts to design and build small molecule probes that can be used to identify, inhibit and image various hydrolytic enzyme targets in models of cancer and infectious disease. This will include recent advances in protease activated fluorescent probes for real-time visualization of tumors during surgery as well our efforts to identify several and image new classes of serine hydrolases in pathogenic and commensal bacteria.
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© (2024) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
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Matthew Bogyo "Protease-activated probes for real-time ratiometric imaging of solid tumors", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC128250K (13 March 2024); https://doi.org/10.1117/12.3009175
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KEYWORDS
Cancer
Diseases and disorders
Pathogens
Visualization
Diagnostics
Lead
Molecules
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