Perovskite-based core-shell nanoparticles: a promising tool for biosensing and imaging

Peuli Nath; Aniruddha Ray

doi:10.1117/12.3003041

13 March 2024 Perovskite-based core-shell nanoparticles: a promising tool for biosensing and imaging

Peuli Nath, Aniruddha Ray

Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC1285902 (2024) https://doi.org/10.1117/12.3003041
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We present a novel perovskite core-multishell nanoparticle (PNCs@polymer) incorporating silica and poly-lactide-co-glycolic acid, that renders excellent water stability for days, thereby establishing their suitability for biomedical applications. Additionally, we created a dual emission ratiometric sensor by incorporating a nitric oxide (NO)-responsive dye within the polymer shell. These nanosensors showed enhanced emission at 586 nm with increasing NO concentration, while the fluorescence from PNCs at 510 nm remains constant. Furthermore, these nanosensors were used to quantify the extracellular NO concentration released from breast cancer cells pretreated with a NO donor, thereby offering dual advantages of both bioimaging and sensing capabilities.

Conference Presentation

Citation Download Citation

Peuli Nath and Aniruddha Ray "Perovskite-based core-shell nanoparticles: a promising tool for biosensing and imaging", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC1285902 (13 March 2024); https://doi.org/10.1117/12.3003041

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