Impact of e-cigarette vape on ex vivo porcine lung optical properties by confocal Raman micro-spectroscopy study

Ali Jaafar; Abbas Albarazanchi; Firas S. Mohammed; Ahmed Al‑Haddad; Maxim E. Darvin; Tamás Váczi; Valery V. Tuchin; Miklós Veres

doi:10.1117/12.3017480

19 June 2024 Impact of e-cigarette vape on ex vivo porcine lung optical properties by confocal Raman micro-spectroscopy study

Ali Jaafar, Abbas Albarazanchi, Firas S. Mohammed, Ahmed Al‑Haddad, Maxim E. Darvin, Tamás Váczi, Valery V. Tuchin, Miklós Veres

Author Affiliations +

Proceedings Volume PC13010, Tissue Optics and Photonics III; PC1301001 (2024) https://doi.org/10.1117/12.3017480
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

The ex vivo porcine lung tissue exposure to nicotine-flavour free e-liquid was examined in-depth using confocal Raman micro-spectroscopy. It was found that the lung-related Raman bands and autofluorescence intensities were enhanced after exposure to e-liquid for all depths and treatment time (first and second treatments) due to the optical clearing effect of glycerol and propylene glycol as an OC agent. The nicotine-flavour free e-liquids that contain glycerol and propylene glycol could potentially be used in clinical protocols for lung disease discrimination in-depth using Raman-based in vivo bronchoscopy due to light scattering reduction as an optical clearing agent.

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Citation Download Citation

Ali Jaafar, Abbas Albarazanchi, Firas S. Mohammed, Ahmed Al‑Haddad, Maxim E. Darvin, Tamás Váczi, Valery V. Tuchin, and Miklós Veres "Impact of e-cigarette vape on ex vivo porcine lung optical properties by confocal Raman micro-spectroscopy study", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC1301001 (19 June 2024); https://doi.org/10.1117/12.3017480

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