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1 March 2007 Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy
Pavel Matousek, Nicholas Stone
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Journal of Biomedical Optics, Vol. 12, Issue 2, 024008 (March 2007). https://doi.org/10.1117/1.2718934
Abstract
Breast calcifications can be found in both benign and malignant lesions, and the composition of these calcifications can indicate the possible disease state. As current practices such as mammography and histopathology examine the morphology of the specimen, they cannot reliably distinguish between the two types of calcification, which frequently are the only mammographic features that indicate the presence of a cancerous lesion. Raman spectroscopy is an optical technique capable of obtaining biochemical information of a sample in situ. We demonstrate for the first time the noninvasive recovery of Raman spectra of calcified materials buried within a chicken breast tissue slab 16 mm thick, achieved using transmission Raman spectroscopy. The spectra of both calcium hydroxyapatite (HAP) and calcium oxalate monohydrate (COM) are obtained and chemically identified. The experimental geometry and gross insensitivity of the Raman signal to the depth of the calcified lesion makes the concept potentially well suited for probing human female breasts, in conjunction with existing mammography or ultrasound, to provide complementary data in the early diagnosis of breast cancer.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Pavel Matousek and Nicholas Stone "Prospects for the diagnosis of breast cancer by noninvasive probing of calcifications using transmission Raman spectroscopy," Journal of Biomedical Optics 12(2), 024008 (1 March 2007). https://doi.org/10.1117/1.2718934
Published: 1 March 2007
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Cited by 99 scholarly publications and 1 patent.
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KEYWORDS
Raman spectroscopy
Tissues
Breast
Tissue optics
Photons
Breast cancer
Calcium
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