In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography

Nikolaos C. Deliolanis; Joshua Dunham; Thomas Wurdinger; Jose-Luiz Figueiredo; Tannous Bakhos; Vasilis Ntziachristos

doi:10.1117/1.3149854

1 May 2009 In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography

Nikolaos C. Deliolanis, Joshua Dunham, Thomas Wurdinger, Jose-Luiz Figueiredo, Tannous Bakhos, Vasilis Ntziachristos

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Journal of Biomedical Optics, Vol. 14, Issue 3, 030509 (May 2009). https://doi.org/10.1117/1.3149854

Abstract

We interrogate the ability of free-space fluorescence tomography to image small animals in vivo using charge-coupled device (CCD) camera measurements over 360-deg noncontact projections. We demonstrate the performance of normalized dual-wavelength measurements that are essential for in-vivo use, as they account for the heterogeneous distribution of photons in tissue. In-vivo imaging is then showcased on mouse lung and brain tumors cross-validated by x-ray microcomputed tomography and histology.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Nikolaos C. Deliolanis, Joshua Dunham, Thomas Wurdinger, Jose-Luiz Figueiredo, Tannous Bakhos, and Vasilis Ntziachristos "In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography," Journal of Biomedical Optics 14(3), 030509 (1 May 2009). https://doi.org/10.1117/1.3149854

Published: 1 May 2009

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