Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence

Reinhold Eichhorn; Gerd Wessler; Matthias Scholz; Dieter Leupold; Goran Stankovic; Susanne Buder; Markus Stuecker; Klaus Hoffmann

doi:10.1117/1.3155511

1 May 2009 Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence

Reinhold Eichhorn, Gerd Wessler, Matthias Scholz, Dieter Leupold, Goran Stankovic, Susanne Buder, Markus Stuecker, Klaus Hoffmann

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Journal of Biomedical Optics, Vol. 14, Issue 3, 034033 (May 2009). https://doi.org/10.1117/1.3155511

Abstract

Because of the increasing incidence of skin cancer, interest in using the autofluorescence of skin tissue as a noninvasive tool for early diagnosis is enforced. Focus is especially on malignant melanotic melanoma. On the basis of a newly developed method to selectively excite melanin fluorescence of skin tissue by stepwise two-photon excitation with nanosecond laser pulses at 810 nm, we have investigated information from this melanin fluorescence with respect to the differentiation of pigmented lesions. A distinct difference in the melanin fluorescence spectrum of malignant melanoma (including melanoma in situ) when compared to that of benign melanocytic lesions (i.e., common nevi) has been found for freshly excised samples as well as for histopathological samples. There is also specific fluorescence from dysplastic nevi. In this way, early detection of malignant melanoma is possible.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Reinhold Eichhorn, Gerd Wessler, Matthias Scholz, Dieter Leupold, Goran Stankovic, Susanne Buder, Markus Stuecker, and Klaus Hoffmann "Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence," Journal of Biomedical Optics 14(3), 034033 (1 May 2009). https://doi.org/10.1117/1.3155511

Published: 1 May 2009

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KEYWORDS

Luminescence

Melanoma

Skin

Tissues

Absorption

Diagnostics

Solids

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