Risk assessment of the application of a plasma jet in dermatology

Jürgen M. Lademann; Heike Richter; Alena Alborova; D. Humme; Alexa Patzelt M.D.; Axel Kramer; K. D. Weltmann; B. Hartmann; C. Ottomann; J. W. Fluhr; P. Hinz; G. Hübner; O. Lademann

doi:10.1117/1.3247156

1 September 2009 Risk assessment of the application of a plasma jet in dermatology

Jürgen M. Lademann, Heike Richter, Alena Alborova, D. Humme, Alexa Patzelt M.D., Axel Kramer, K. D. Weltmann, B. Hartmann, C. Ottomann, J. W. Fluhr, P. Hinz, G. Hübner, O. Lademann

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Journal of Biomedical Optics, Vol. 14, Issue 5, 054025 (September 2009). https://doi.org/10.1117/1.3247156

Abstract

Regardless of the fact that several highly efficient antiseptics are commercially available, the antiseptic treatment of chronic wounds remains a problem. In the past, electrical plasma discharges have been frequently used in biometrical science for disinfection and sterilization of material surfaces. Plasma systems usually have a temperature of several hundred degrees. Recently, it was reported that "cold" plasma can be applied onto living tissue. In in vitro studies on cell culture, it could be demonstrated that this new plasma possesses excellent antiseptic properties. We perform a risk assessment concerning the in vivo application of a "cold" plasma jet on patients and volunteers. Two potential risk factors, UV radiation and temperature, are evaluated. We show that the UV radiation of the plasma in the used system is an order of magnitude lower than the minimal erythema dose, necessary to produce sunburn on the skin in vivo. Additionally, thermal damage of the tissue by the plasma can be excluded. The results of the risk assessment stimulate the in vivo application of the investigated plasma jet in the treatment of chronic wounds.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jürgen M. Lademann, Heike Richter, Alena Alborova, D. Humme, Alexa Patzelt M.D., Axel Kramer, K. D. Weltmann, B. Hartmann, C. Ottomann, J. W. Fluhr, P. Hinz, G. Hübner, and O. Lademann "Risk assessment of the application of a plasma jet in dermatology," Journal of Biomedical Optics 14(5), 054025 (1 September 2009). https://doi.org/10.1117/1.3247156

Published: 1 September 2009

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