Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging

Farouk Nouizi; Alex T. Luk; Dave Thayer; Yuting Lin; Seunghoon Ha; Gultekin Gulsen

doi:10.1117/1.JBO.21.1.016009

20 January 2016 Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging

Farouk Nouizi, Alex T. Luk, Dave Thayer, Yuting Lin, Seunghoon Ha, Gultekin Gulsen

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Journal of Biomedical Optics, Vol. 21, Issue 1, 016009 (January 2016). https://doi.org/10.1117/1.JBO.21.1.016009

Abstract

We present experimental results that validate our imaging technique termed photomagnetic imaging (PMI). PMI illuminates the medium under investigation with a near-infrared light and measures the induced temperature increase using magnetic resonance imaging. A multiphysics solver combining light and heat propagation is used to model spatiotemporal distribution of temperature increase. Furthermore, a dedicated PMI reconstruction algorithm has been developed to reveal high-resolution optical absorption maps from temperature measurements. Being able to perform measurements at any point within the medium, PMI overcomes the limitations of conventional diffuse optical imaging. We present experimental results obtained on agarose phantoms mimicking biological tissue with inclusions having either different sizes or absorption contrasts, located at various depths. The reconstructed images show that PMI can successfully resolve these inclusions with high resolution and recover their absorption coefficient with high-quantitative accuracy. Even a 1-mm inclusion located 6-mm deep is recovered successfully and its absorption coefficient is underestimated by only 32%. The improved PMI system presented here successfully operates under the maximum skin exposure limits defined by the American National Standards Institute, which opens up the exciting possibility of its future clinical use for diagnostic purposes.

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Farouk Nouizi, Alex T. Luk, Dave Thayer, Yuting Lin, Seunghoon Ha, and Gultekin Gulsen "Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging," Journal of Biomedical Optics 21(1), 016009 (20 January 2016). https://doi.org/10.1117/1.JBO.21.1.016009

Published: 20 January 2016

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KEYWORDS

Absorption

Temperature metrology

Diffuse optical imaging

Magnetic resonance imaging

Tissue optics

Signal to noise ratio

Inverse optics

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