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21 December 2016 Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation
Colin L. Schlosser, Nico Bodenschatz, Sylvia F. Lam, Marette Lee, Jessica N. McAlpine, Dianne M. Miller, Dirk J. T. Van Niekerk, Michele Follen M.D., Martial Guillaud, Calum E. MacAulay, Pierre M. Lane
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Journal of Biomedical Optics, Vol. 21, Issue 12, 126011 (December 2016). https://doi.org/10.1117/1.JBO.21.12.126011
Abstract
Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the perceived variability within and the subtle differences between the four tissue groups in the context of endomicroscopic in vivo pathology. Conclusions are drawn on the general ability to distinguish and diagnose tissue types, on the need for imaging depth control to enhance differentiation, and on the possible risks for diagnostic misinterpretations.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Colin L. Schlosser, Nico Bodenschatz, Sylvia F. Lam, Marette Lee, Jessica N. McAlpine, Dianne M. Miller, Dirk J. T. Van Niekerk, Michele Follen M.D., Martial Guillaud, Calum E. MacAulay, and Pierre M. Lane "Fluorescence confocal endomicroscopy of the cervix: pilot study on the potential and limitations for clinical implementation," Journal of Biomedical Optics 21(12), 126011 (21 December 2016). https://doi.org/10.1117/1.JBO.21.12.126011
Received: 28 June 2016; Accepted: 29 November 2016; Published: 21 December 2016
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Cited by 24 scholarly publications and 1 patent.
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KEYWORDS
Tissues
Endomicroscopy
Luminescence
In vivo imaging
Cervix
Diagnostics
Confocal microscopy
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