Volume 28 Issue 1 | Journal of Biomedical Optics

Journal of Biomedical Optics

VOL. 28 · NO. 1 | January 2023

CONTENTS

IN THIS ISSUE

Editorial (1)

General (2)

Imaging (4)

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Editorial

JBO 2022 List of Reviewers

Journal of Biomedical Optics, Vol. 28, Issue 01, 010102, (January 2023) https://doi.org/10.1117/1.JBO.28.1.010102

TOPICS: Lithium, Lutetium, Chaos, Silicon, Bismuth

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General

Noninvasive optical monitoring of pulmonary embolism: a Monte Carlo study on visible Chinese human thoracic tissues

Shuo Meng, Hengjie Su, Jianghui Guo, Lingxiao Wang, Ting Li

Journal of Biomedical Optics, Vol. 28, Issue 01, 015001, (January 2023) https://doi.org/10.1117/1.JBO.28.1.015001

TOPICS: Tissues, Arteries, Monte Carlo methods, Near infrared spectroscopy, Blood, Tissue optics, 3D modeling, Signal detection, Photon transport, Skin

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Cerebral tissue oxygenation response to brain irradiation measured during clinical radiotherapy

Teemu Myllylä, Vesa Korhonen, Priya Karthikeyan, Ulriika Honka, Jesse Lohela, Kalle Inget, Hany Ferdinando, Sakari Karhula, Juha Nikkinen

Journal of Biomedical Optics, Vol. 28, Issue 01, 015002, (January 2023) https://doi.org/10.1117/1.JBO.28.1.015002

TOPICS: Radiotherapy, Oxygenation, Brain, Tumors, Hemodynamics, Brain tissue, Tissues, Near infrared spectroscopy, Head, Hypoxia

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Significance

Cancer therapy treatments produce extensive changes in the physiological and morphological properties of tissues, which are also individual dependent. Currently, a key challenge involves developing more tailored cancer therapy, and consequently, individual biological response measurement during therapy, such as tumor hypoxia, is of high interest. This is the first time human cerebral haemodynamics and cerebral tissue oxygenation index (TOI) changes were measured during the irradiation in clinical radiotherapy and functional near-infrared spectroscopy (fNIRS) technique was demonstrated as a feasible technique for clinical use in radiotherapy, based on 34 online patient measurements.

Aim

Our aim is to develop predictive biomarkers and noninvasive real-time methods to establish the effect of radiotherapy during treatment as well as to optimize radiotherapy dose planning for individual patients. In particular, fNIRS-based technique could offer an effective and clinically feasible online technique for continuous monitoring of brain tissue hypoxia and responses to chemo- and radiotherapy, which involves modulating tumor oxygenation to increase or decrease tumor hypoxia. We aim to show that fNIRS is feasible for repeatability measuring in patient radiotherapy, the temporal alterations of tissue oxygenation induced by radiation.

Approach

Fiber optics setup using multiwavelength fNIRS was built and combined with a medical linear accelerator to measure cerebral tissue oxygenation changes during the whole-brain radiotherapy treatment, where the radiation dose is given in whole brain area only preventing dosage to eyes. Correlation of temporal alterations in cerebral haemodynamics and TOI response to brain irradiation was quantified.

Results

Online fNIRS patient measurement of cerebral haemodynamics during clinical brain radiotherapy is feasible in clinical environment, and results based on 34 patient measurements show strong temporal alterations in cerebral haemodynamics and decrease in TOI during brain irradiation and confirmed the repeatability. Our proof-of-concept study shows evidently that irradiation causes characteristic immediate changes in brain tissue oxygenation.

Conclusions

In particular, TOI seems to be a sensitive parameter to observe the tissue effects of radiotherapy. Monitoring the real-time interactions between the subjected radiation dose and corresponding haemodynamic effects may provide important tool for the researchers and clinicians in the field of radiotherapy. Eventually, presented fNIRS technique could be used for improving dose planning and safety control for individual patients.

Imaging

Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology

Yuli W. Heinson, Julie L. Han, Emilia Entcheva

Journal of Biomedical Optics, Vol. 28, Issue 01, 016001, (January 2023) https://doi.org/10.1117/1.JBO.28.1.016001

TOPICS: Calcium, Imaging systems, Electrophysiology, Portability, Optogenetics, Cameras, Light sources and illumination, Light emitting diodes, Signal to noise ratio, Sensors

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Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment

Jackson Coole, David Brenes, Ruchika Mitbander, Imran Vohra, Huayu Hou, Alex Kortum, Yubo Tang, Yajur Maker, Richard Schwarz, Jennifer Carns, Hawraa Badaoui, Michelle Williams, Nadarajah Vigneswaran, Ann Gillenwater, Rebecca Richards-Kortum

Journal of Biomedical Optics, Vol. 28, Issue 01, 016002, (January 2023) https://doi.org/10.1117/1.JBO.28.1.016002

TOPICS: Biopsy, Cancer, Microscopes, Multimodal imaging, Optical imaging, Imaging systems, Cameras, Tongue, Projection systems, Biomedical optics

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Assessment of nonalcoholic fatty liver function by photoacoustic imaging

Jinge Yang, Tingting Qiu, Teng Pan, Guang Zhang, Wenwu Ling, Yuqing Zhou, Yan Luo, Huabei Jiang

Journal of Biomedical Optics, Vol. 28, Issue 01, 016003, (January 2023) https://doi.org/10.1117/1.JBO.28.1.016003

TOPICS: Liver, In vivo imaging, Photoacoustic imaging, Tissues, Animal model studies, Imaging systems, Animals, Computing systems, Ultrasound transducers, Diseases and disorders

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Signal to noise ratio quantifies the contribution of spectral channels to classification of human head and neck tissues ex vivo using deep learning and multispectral imaging

George S. Liu, Jared A. Shenson, Joyce E. Farrell, Nikolas H. Blevins

Journal of Biomedical Optics, Vol. 28, Issue 01, 016004, (January 2023) https://doi.org/10.1117/1.JBO.28.1.016004

TOPICS: Nervous system, Tissues, Signal to noise ratio, RGB color model, Image classification, Education and training, Nerve, Sensors, Bone, Multispectral imaging

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