Open Access
19 March 2024 Theoretical and experimental study of attenuation in cancellous bone
Wenyi Xu, Weiya Xie, Dong Yu, Haohan Sun, Ying Gu, Xingliang Tao, Menglu Qian, Liming Cheng, Hao Wang, Qian Cheng
Author Affiliations +
Abstract

Significance

Photoacoustic (PA) technology shows great potential for bone assessment. However, the PA signals in cancellous bone are complex due to its complex composition and porous structure, making such signals challenging to apply directly in bone analysis.

Aim

We introduce a photoacoustic differential attenuation spectrum (PA-DAS) method to separate the contribution of the acoustic propagation path to the PA signal from that of the source, and theoretically and experimentally investigate the propagation attenuation characteristics of cancellous bone.

Approach

We modified Biot’s theory by accounting for the high frequency and viscosity. In parallel with the rabbit osteoporosis model, we build an experimental PA-DAS system featuring an eccentric excitation differential detection mechanism. Moreover, we extract a PA-DAS quantization parameter—slope—to quantify the attenuation of high- and low-frequency components.

Results

The results show that the porosity of cancellous bone can be evaluated by fast longitude wave attenuation at different frequencies and the PA-DAS slope of the osteoporotic group is significantly lower compared with the normal group (**p<0.01).

Conclusions

Findings demonstrate that PA-DAS effectively differentiates osteoporotic bone from healthy bone, facilitating quantitative assessment of bone mineral density, and osteoporosis diagnosis.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Wenyi Xu, Weiya Xie, Dong Yu, Haohan Sun, Ying Gu, Xingliang Tao, Menglu Qian, Liming Cheng, Hao Wang, and Qian Cheng "Theoretical and experimental study of attenuation in cancellous bone," Journal of Biomedical Optics 29(S1), S11526 (19 March 2024). https://doi.org/10.1117/1.JBO.29.S1.S11526
Received: 9 October 2023; Accepted: 19 February 2024; Published: 19 March 2024
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KEYWORDS
Bone

Signal attenuation

Porosity

Acoustic waves

Transducers

Acoustics

Osteoporosis

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