Dr. Arin Can Ülkü Profile

Dr. Arin Can Ülkü

Electrical Design Engineer at Thermo Fisher Scientific (Bremen) GmbH

SPIE Involvement:

Author

Publications (18)

Proceedings Article | 13 March 2024 Presentation

3D fluorescence molecular tomography utilizing a novel SPAD camera

Navid Ibtehaj Nizam, Vikas Pandey, Ismail Erbas, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Xavier Michalet, Xavier Intes

Proceedings Volume PC12834, PC1283407 (2024) https://doi.org/10.1117/12.2692977

KEYWORDS: Fluorescence, Cameras, Fluorescence tomography, Stereoscopic cameras, Imaging systems, Structured light, Fluorescence imaging, Tomography, Reflectivity, Near infrared

Read Abstract +

Proceedings Article | 13 March 2024 Presentation + Paper

SwissSPAD2/3: a family of natively digital, time gated SPAD cameras with continuous streaming at up to 100 kpfs and picosecond system-level synchronization for quantum imaging applications

Paul Mos, Michael Wayne, Andrei Ardelean, Arin Ulku, Edoardo Charbon, Claudio Bruschini

Proceedings Volume 12912, 129120Q (2024) https://doi.org/10.1117/12.2692931

KEYWORDS: Field programmable gate arrays, Single photon avalanche diodes, Binary data, Picosecond phenomena, Sensors, Quantum gates, Cameras, Imaging systems, Digital cameras, Quantum imaging

Read Abstract +

Proceedings Article | 13 March 2024 Poster

Deep Learning model for efficient instrument response function deconvolution in fluorescence lifetime imaging

Vikas Pandey, Xavier Michalet, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Xavier Intes

Proceedings Volume PC12834, PC128340P (2024) https://doi.org/10.1117/12.3002573

KEYWORDS: Equipment, Deep learning, Instrument modeling, Image deconvolution, Fluorescence lifetime imaging, Mathematical modeling, Imaging systems, Deconvolution, Fluorescence, Dyes

SPIE Journal Paper | 17 January 2024 Open Access

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Arthur F. Petusseau, Samuel S. Streeter, Arin Ulku, Yichen Feng, Kimberley S. Samkoe, Claudio Bruschini, Edoardo Charbon, Brian W. Pogue, Petr Bruza

JBO, Vol. 29, Issue 01, 016004, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.1.016004

KEYWORDS: Fluorescence, Tissues, Reflectivity, Optical properties, Single photon avalanche diodes, Fluorescence intensity, Calibration, Tumors, Time of flight imaging, Gelatin

Read Abstract +

SignificanceFluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecular phenotypic information about the disease being resected. Conventional fluorescence-guided surgery relies on long, microsecond scale laser pulses to excite fluorescent probes. However, this technique only provides two-dimensional information; crucial depth information, such as the location of malignancy below the tissue surface, is not provided.AimWe developed a depth sensing imaging technique using light detection and ranging (LiDAR) time-of-flight (TOF) technology to sense the depth of target tissue while overcoming the influence of tissue optical properties and fluorescent probe concentration.ApproachThe technology is based on a large-format (512×512 pixel), binary, gated, single-photon avalanche diode (SPAD) sensor with an 18 ps time-gate step, synchronized with a picosecond pulsed laser. The fast response of the sensor was developed and tested for its ability to quantify fluorescent inclusions at depth and optical properties in tissue-like phantoms through analytical model fitting of the fast temporal remission data.ResultsAfter calibration and algorithmic extraction of the data, the SPAD LiDAR technique allowed for sub-mm resolution depth sensing of fluorescent inclusions embedded in tissue-like phantoms, up to a maximum of 5 mm in depth. The approach provides robust depth sensing even in the presence of variable tissue optical properties and separates the effects of fluorescence depth from absorption and scattering variations.ConclusionsLiDAR TOF fluorescence imaging using an SPAD camera provides both fluorescence intensity images and the temporal profile of fluorescence, which can be used to determine the depth at which the signal is emitted over a wide field of view. The proposed tool enables fluorescence imaging at a higher depth in tissue and with higher spatial precision than standard, steady-state fluorescence imaging tools, such as intensity-based near-infrared fluorescence imaging, optical coherence tomography, Raman spectroscopy, or confocal microscopy. Integration of this technique into a standard surgical tool could enable rapid, more accurate estimation of resection boundaries, thereby improving the surgeon’s efficacy and efficiency, and ultimately improving patient outcomes.

DOWNLOAD PAPER

Proceedings Article | 25 April 2023 Presentation + Paper

NIR fluorescence lifetime macroscopic imaging with a novel time-gated SPAD camera

Xavier Michalet, Arin Ulku, Michael Wayne, Shimon Weiss, Claudio Bruschini, Edoardo Charbon

Proceedings Volume 12384, 1238409 (2023) https://doi.org/10.1117/12.2649227

KEYWORDS: Fluorescence lifetime imaging, Gated imaging, Single photon avalanche diodes, Fluorescence, Near infrared, Dyes, Pulsed laser operation

Read Abstract +

Proceedings Article | 15 March 2023 Presentation + Paper

Heralded spectroscopy: a new single-particle probe for nanocrystal photophysics

Gur Lubin, Ron Tenne, Arin Can Ulku, Ivan Michel Antolovic, Samuel Burri, Sean Karg, Venkata Jayasurya Yallapragada, Gili Yaniv, Miri Kazes, Daniel Amgar, Nadav Frenkel, Claudio Bruschini, Edoardo Charbon, Dan Oron

Proceedings Volume 12386, 1238603 (2023) https://doi.org/10.1117/12.2650463

KEYWORDS: Spectroscopy, Quantum correlations, Nanocrystals, Quantum dot emission, Single photon avalanche diodes, Detector arrays, Quantum probes, Quantum optics experiments, Materials properties, Biexcitons, Excitons

Read Abstract +

Proceedings Article | 15 March 2023 Poster + Paper

High-efficiency fill factor recovery using refractive microlens arrays imprinted on 0.5-256 kpixel front-side illuminated SPAD imagers

C. Bruschini, M. Antolovic, F. Zanella, A. Ulku, S. Lindner, A. Kalayanov, T. Milanese, E. Bernasconi, V. Pešić, E. Charbon

Proceedings Volume 12433, 124330K (2023) https://doi.org/10.1117/12.2652962

KEYWORDS: Single photon avalanche diodes, Microlens, Microlens array, Imaging systems, Image sensors, Simulations, Sensors, Polymers, Reticles, Photoresist materials

Read Abstract +

Proceedings Article | 15 March 2023 Presentation + Paper

LinoSPAD2: a 512x1 linear SPAD camera with system-level 135-ps SPTR and a reconfigurable computational engine for time-resolved single-photon imaging

Claudio Bruschini, Samuel Burri, Ermanno Bernasconi, Tommaso Milanese, Arin Ulku, Harald Homulle, Edoardo Charbon

Proceedings Volume 12430, 124300K (2023) https://doi.org/10.1117/12.2652248

KEYWORDS: Single photon avalanche diodes, Field programmable gate arrays, Imaging systems, Photons, Logic, Image processing, Cameras, Picosecond phenomena, Photon counting, Data processing

Read Abstract +

Proceedings Article | 9 March 2022 Presentation

Heralded spectroscopy of single nanocrystals

Gur Lubin, Ron Tenne, Arin Can Ulku, Ivan Antolovic, Samuel Burri, Sean Karg, Venkata Jayasurya Yallapragada, Claudio Bruschini, Edoardo Charbon, Dan Oron

Proceedings Volume PC12016, PC120162M (2022) https://doi.org/10.1117/12.2616990

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Characterization of a large gated SPAD array for in vivo fluorescence lifetime imaging of drug target engagement

Jason Smith, Alena Rudkouskaya, Shan Gao, Arin Ulku, Claudio Bruschini, Edoardo Charbon, Shimon Weiss, Margarida Barroso, Xavier Intes, Xavier Michalet

Proceedings Volume PC11964, PC1196408 (2022) https://doi.org/10.1117/12.2609888

KEYWORDS: In vivo imaging, Fluorescence lifetime imaging, Sensors, In vitro testing, Visible radiation, Tumors, Near infrared, Luminescence, Fluorescence resonance energy transfer, Detector development

Read Abstract +

Proceedings Article | 7 March 2022 Presentation

Sub-surface fluorescence time-of-flight imaging using a large format SPAD sensor

Arthur Pétusseau, Petr Bruza, Arin Ulku, Samuel Streeter, Kimberley Samkoe, Claudio Bruschini, Edoardo Charbon, Brian Pogue

Proceedings Volume PC11943, PC1194304 (2022) https://doi.org/10.1117/12.2607719

KEYWORDS: Luminescence, Time of flight imaging, Sensors, Scattering, Tissues, Light scattering, Laser scattering, Surgery, Picosecond phenomena, Natural surfaces

Read Abstract +

Proceedings Article | 4 March 2022 Presentation + Paper

NIR fluorescence lifetime macroscopic imaging with a time-gated SPAD camera

X. Michalet, A. Ulku, J. Smith, C. Bruschini, S. Weiss, E. Charbon, X. Intes

Proceedings Volume 11965, 1196507 (2022) https://doi.org/10.1117/12.2607833

KEYWORDS: Signal to noise ratio, Near infrared, Sensors, Fluorescence lifetime imaging, Cameras, Pulsed laser operation, Luminescence, Laser scattering, Data acquisition, Picosecond phenomena

Read Abstract +

Proceedings Article | 11 July 2021 Poster + Presentation + Paper

Towards quantum 3D imaging devices

Gianlorenzo Massaro, Cristoforo Abbattista, Leonardo Amoruso, Samuel Burri, Edoardo Charbon, Francesco Di Lena, Augusto Garuccio, Davide Giannella, Zdeněk Hradil, Michele Iacobellis, Paul Mos, Libor Motka, Martin Paùr, Francesco V. Pepe, Michal Peterek, Isabella Petrelli, Jaroslav Řeháček, Francesca Santoro, Francesco Scattarella, Arin Ulku, Sergii Vasiukov, Michael Wayne, Milena D'Angelo, Claudio Bruschini, Maria Ieronymaki, Bohumil Stoklasa

Proceedings Volume 11844, 1184410 (2021) https://doi.org/10.1117/12.2600791

Read Abstract +

Proceedings Article | 5 March 2021 Presentation

Megapixel time-gated SPAD image sensor for scientific imaging applications

Kazuhiro Morimoto, Andrei Ardelean, Ming-Lo Wu, Arin Can Ulku, Ivan Michel Antolovic, Vytautas Zickus, Valentin Kapitany, Areeba Fatima, Alex Turpin, Robert Insall, Jamie Whitelaw, Laura Machesky, Claudio Bruschini, Daniele Faccio, Edoardo Charbon

Proceedings Volume 11654, 116540U (2021) https://doi.org/10.1117/12.2582444

KEYWORDS: Optical sensors, Image sensors, Single photon detectors, Sensors, Picosecond phenomena, Fluorescence lifetime imaging, Cameras, Time correlated photon counting, Sensor technology, Photodetectors

Read Abstract +

Proceedings Article | 22 February 2019 Presentation + Paper

Fluorescence lifetime imaging with a single-photon SPAD array using long overlapping gates: an experimental and theoretical study

Andrei Ardelean, Arin Ulku, Xavier Michalet, Edoardo Charbon, Claudio Bruschini

Proceedings Volume 10882, 108820Y (2019) https://doi.org/10.1117/12.2511287

KEYWORDS: Fluorescence lifetime imaging, Photons, Rhodamine, Picosecond phenomena, Signal to noise ratio, Statistical analysis, Data acquisition, Avalanche photodiodes, Data modeling, Microlens array

Read Abstract +

Proceedings Article | 22 February 2019 Presentation + Paper

Phasor-based widefield FLIM using a gated 512×512 single-photon SPAD imager

Arin Can Ulku, Claudio Bruschini, Ivan Michel Antolovic, Shimon Weiss, Xavier Michalet, Edoardo Charbon

Proceedings Volume 10882, 108820M (2019) https://doi.org/10.1117/12.2511148

KEYWORDS: Fluorescence lifetime imaging, Imaging systems, Luminescence, Photon counting, Quantum dots, Data processing, Dispersion, Rhodamine, Single photon detectors, Microscopy

Read Abstract +

Proceedings Article | 21 February 2019 Paper

Optical-stack optimization for improved SPAD photon detection efficiency

I. Michel Antolovic, Arin C. Ulku, Ekin Kizilkan, Scott Lindner, Frédéric Zanella, Rolando Ferrini, Marc Schnieper, Edoardo Charbon, Claudio Bruschini

Proceedings Volume 10926, 109262T (2019) https://doi.org/10.1117/12.2511301

KEYWORDS: Microlens, Microlens array, Photodetectors, Semiconducting wafers, Reticles, Etching, Sensors, Photoresist materials, CMOS sensors

Read Abstract +

Proceedings Article | 14 March 2018 Presentation

A time-gated large-array SPAD camera for picosecond resolution real-time FLIM (Conference Presentation)

Arin Can Ulku, Claudio Bruschini, Shimon Weiss, Xavier Michalet, Edoardo Charbon

Proceedings Volume 10498, 104980M (2018) https://doi.org/10.1117/12.2288170

KEYWORDS: Fluorescence lifetime imaging, Cameras, Picosecond phenomena, Sensors, Image sensors, Avalanche photodiodes, Luminescence, Fluorescence resonance energy transfer, Single photon, Microscopy

Read Abstract +

Showing 5 of 18 publications

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years