Prof. Annika M. Enejder Profile

Prof. Annika M. Enejder

Assistant Professor and Research Leader at Chalmers Univ of Technology

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Author

Publications (15)

Proceedings Article | 28 February 2014 Paper

CARS microscopy of Alzheimer's diseased brain tissue

Annika Enejder, Juris Kiskis, Helen Fink, Lena Nyberg, Jakob Thyr, Jia-Yi Li

Proceedings Volume 8948, 89480U (2014) https://doi.org/10.1117/12.2040915

KEYWORDS: Microscopy, Luminescence, Tissues, Brain, Alzheimer's disease, Proteins, Biological research, Raman spectroscopy, Optical parametric oscillators, Laser scanners

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Proceedings Article | 22 February 2013 Paper

Neuronal cell growth on polymeric scaffolds studied by CARS microscopy

Annika Enejder, Henning Hagman, Juris Kiskis

Proceedings Volume 8588, 858808 (2013) https://doi.org/10.1117/12.2005002

KEYWORDS: Microscopy, Neodymium, Near field scanning optical microscopy, Near field optics, Brain, Neurons, CARS tomography, Nanostructures, Proteins, Tissues

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Proceedings Article | 15 February 2012 Paper

Neuronal cell growth on polymeric scaffolds studied by CARS microscopy

Annika Enejder, Helen Fink, Hans-Georg Kuhn

Proceedings Volume 8226, 82261W (2012) https://doi.org/10.1117/12.910134

KEYWORDS: Neurons, Microscopy, Polymers, 3D image processing, Optical parametric oscillators, Microscopes, Visualization, Signal detection, Imaging systems, Neural networks

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Proceedings Article | 23 February 2011 Paper

Chemical release from single-PMMA microparticles monitored by CARS microscopy

Annika Enejder, Fredrik Svedberg, Lars Nordstierna, Magnus Nydén

Proceedings Volume 7903, 79030S (2011) https://doi.org/10.1117/12.874537

KEYWORDS: Microscopy, Particles, Polymethylmethacrylate, Optical parametric oscillators, Diffusion, Microscopes, Raman spectroscopy, Data modeling, Image resolution, Image acquisition

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SPIE Journal Paper | 1 February 2011 Open Access

Coherent anti-Stokes Raman scattering microscopy of human smooth muscle cells in bioengineered tissue scaffolds

Christian Brackmann, Annika Enejder, Maricris Esguerra, Daniel Olausson, Dick Delbro, Alexandra Krettek, Paul Gatenholm

JBO, Vol. 16, Issue 02, 021115, (February 2011) https://doi.org/10.1117/12.10.1117/1.3534782

KEYWORDS: Microscopy, Second-harmonic generation, Visualization, CARS tomography, Optical fibers, Tissue engineering, Tissues, Optical parametric oscillators, 3D image processing, Microscopes

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SPIE Journal Paper | 1 November 2010 Open Access

Nonlinear microscopy of lipid storage and fibrosis in muscle and liver tissues of mice fed high-fat diets

Christian Brackmann, Britt Gabrielsson, Fredrik Svedberg, Agneta Holmang, Ann-Sofie Sandberg, Annika Enejder

JBO, Vol. 15, Issue 06, 066008, (November 2010) https://doi.org/10.1117/12.10.1117/1.3505024

KEYWORDS: Microscopy, Liver, Tissues, Second-harmonic generation, Visualization, Collagen, Nonlinear optics, Optical parametric oscillators, Biological research, Chemical analysis

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SPIE Journal Paper | 1 March 2010 Open Access

Nonlinear microscopy with fiber laser continuum excitation

Fredrik Svedberg, Christian Brackmann, Thomas Hellerer, Annika Enejder

JBO, Vol. 15, Issue 02, 026026, (March 2010) https://doi.org/10.1117/12.10.1117/1.3374039

KEYWORDS: Femtosecond phenomena, Microscopy, Picosecond phenomena, Fiber lasers, Laser systems engineering, Second-harmonic generation, Imaging systems, Optical parametric oscillators, Complex systems, Nonlinear optics

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Proceedings Article | 11 February 2010 Paper

CARS and SHG microscopy of artificial bioengineered tissues

Annika Enejder, Christian Brackmann, Jan-Olof Dahlberg, Engin Vrana, Paul Gatenholm

Proceedings Volume 7569, 756906 (2010) https://doi.org/10.1117/12.841251

KEYWORDS: Microscopy, Second-harmonic generation, Tissues, Collagen, Optical parametric oscillators, Signal processing, Visualization, Bacteria, Light scattering, Microscopes

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Proceedings Article | 13 February 2009 Paper

CARS and SHG microscopy for the characterization of bacterial cellulose

Annika Enejder, Christian Brackmann, Aase Bodin, Madeleine Åkeson, Paul Gatenholm

Proceedings Volume 7183, 71830U (2009) https://doi.org/10.1117/12.809659

KEYWORDS: Second-harmonic generation, Tissues, Microscopy, Bacteria, Microscopes, Blood vessels, Optical parametric oscillators, Veins, Visualization, Arteries

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We have developed a protocol employing dual-mode non-linear microscopy for the monitoring of the biosynthesis of bacterial cellulose at a single-fiber level, with the fundamental aim to achieve a product with material properties similar to those of human blood vessels. Grown in a tubular geometry it could then be used as a natural and biocompatible source of replacement tissue in conjunction with cardiovascular surgery. The bacteria (Acetobacter xylinum) were selectively visualized based on the CH₂ vibration of its organic macromolecular contents by the Coherent Anti-Stokes Raman Scattering (CARS) process and, simultaneously, the non-centrosymmetrically ordered, birefringent cellulose fibers were depicted by the Second Harmonic Generation (SHG) process. This dual-channel detection approach allows the monitoring of cellulose-fiber formation in vivo and to determine the influence of e.g. different growth conditions on fiber thickness and orientation, their assembling into higher-order structures and overall network density. The bacterial and fiber distributions were monitored in a simple microscope cultivation chamber, as well as in samples harvested during the actual fermentation process of tubular cellulose grafts. The CARS and SHG co-localization images reveal that highest bacterial population densities can be observed in the surface regions of the cellulose tissue, where the primary growth presumably takes place. The cellulose network morphology was also compared with that of human arteries and veins, from which we conclude that the cellulose matrix is comparatively homogeneous in contrast to the wavy band-like supra-formations of collagen in the native tissue. This prompts for sophisticated fermentation methods by which tunnels and pores of appropriate sizes and shapes can be introduced in the cellulose network in a controllable way. With this protocol we hope to contribute to the fundamental knowledge required for optimal production of bioengineered cellulose tissues, eventually being available for clinical use.

Proceedings Article | 15 February 2008 Paper

CARS microscopy for the monitoring of lipid storage in C. elegans

Annika Enejder, Christian Brackmann, Claes Axäng, Madeleine Åkeson, Marc Pilon

Proceedings Volume 6860, 686012 (2008) https://doi.org/10.1117/12.775288

KEYWORDS: Microscopy, Luminescence, Organisms, Visualization, Molecules, Microscopes, Photons, Mode conditioning cables, Optical parametric oscillators, Genetics

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Proceedings Article | 10 February 2007 Paper

Dual-CARS microscopy

Annika Enejder, Christian Brackmann, Ondrej Burkacky, Madeleine Åkeson

Proceedings Volume 6442, 64420G (2007) https://doi.org/10.1117/12.714388

KEYWORDS: Microscopy, Optical parametric oscillators, Crystals, Yeast, Visualization, Molecules, Signal detection, Glasses, Image analysis, Imaging spectroscopy

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Proceedings Article | 23 February 2006 Paper

CARS microscopy for the monitoring of fat deposition mechanisms in a living organism

Annika Enejder, Thomas Hellerer, Per Hillertz, Christian Brackmann, Claes Axäng, Marc Pilon

Proceedings Volume 6089, 60890D (2006) https://doi.org/10.1117/12.659069

KEYWORDS: Microscopy, Organisms, Molecules, Microscopes, Mode conditioning cables, CARS tomography, Raman spectroscopy, Genetics, Signal detection, Laser optics

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SPIE Journal Paper | 1 May 2005 Open Access

Raman spectroscopy for noninvasive glucose measurements

Annika Enejder, Thomas Scecina, Jeankun Oh, Martin Hunter, WeiChuan Shih, Slobodan Sasic, Gary Horowitz, Michael Feld

JBO, Vol. 10, Issue 03, 031114, (May 2005) https://doi.org/10.1117/12.10.1117/1.1920212

KEYWORDS: Glucose, Raman spectroscopy, Calibration, Blood, Skin, Spectroscopy, Tissue optics, In vivo imaging, Statistical analysis, Signal to noise ratio

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Proceedings Article | 21 June 2004 Paper

Highly efficient coherent anti-Stokes Raman scattering (CARS) microscopy

Thomas Hellerer, Annika Enejder, Ondrej Burkacky, Andreas Zumbusch

Proceedings Volume 5323, (2004) https://doi.org/10.1117/12.528265

KEYWORDS: Microscopy, Spectral resolution, CARS tomography, Pulsed laser operation, Signal detection, Picosecond phenomena, Nonlinear optics, Microscopes, Femtosecond phenomena, Signal generators

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Proceedings Article | 22 November 2000 Paper

Accelerated Monte Carlo models to simulate fluorescence of layered tissue

Stefan Andersson-Engels, Annika Enejder, Johannes Swartling, Antonio Pifferi

Proceedings Volume 4160, (2000) https://doi.org/10.1117/12.407617

KEYWORDS: Monte Carlo methods, Luminescence, Photon transport, Tissues, Optical properties, Tissue optics, Absorption, Laser tissue interaction, Optical computing, Fluorescence spectroscopy

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Showing 5 of 15 publications

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