SignificancePhotoacoustic imaging (PAI) enables the visualization of optical contrast with ultrasonic imaging. It is a field of intense research, with great promise for clinical application. Understanding the principles of PAI is important for engineering research and image interpretation.AimIn this tutorial review, we lay out the imaging physics, instrumentation requirements, standardization, and some practical examples for (junior) researchers, who have an interest in developing PAI systems and applications for clinical translation or applying PAI in clinical research.ApproachWe discuss PAI principles and implementation in a shared context, emphasizing technical solutions that are amenable to broad clinical deployment, considering factors such as robustness, mobility, and cost in addition to image quality and quantification.ResultsPhotoacoustics, capitalizing on endogenous contrast or administered contrast agents that are approved for human use, yields highly informative images in clinical settings, which can support diagnosis and interventions in the future.ConclusionPAI offers unique image contrast that has been demonstrated in a broad set of clinical scenarios. The transition of PAI from a “nice-to-have” to a “need-to-have” modality will require dedicated clinical studies that evaluate therapeutic decision-making based on PAI and consideration of the actual value for patients and clinicians, compared with the associated cost.
Kidney transplantation is the treatment of choice for most patients with end-stage kidney disease. Before transplantation, the kidney has to be carefully evaluated. In this study, we investigate the added value of photoacoustic imaging (PA) employed for kidney quality evaluation. Specifically, the oxygenation of the pig kidney was quantified and used as the quality metric. We quantified the oxygenation of perfused kidneys separated between control and experimental (with induced necrosis) groups. The preliminary results suggest that the oxygenation level can be a valuable metric of kidney quality.
Fusion-based ultrasound (US)-guided biopsy in a breast is challenging due to the high deformability of the tissue combined with the fact that the breast is usually differently deformed in CT, MR, and US acquisition which makes registration difficult. With this phantom study, we demonstrate the feasibility of a fusion-based ultrasound-guided method for breast biopsy. 3D US and 3D CT data were acquired using dedicated imaging setups of a breast phantom freely hanging in prone position with lesions. The 3D breast CT set up was provided by Koning (Koning Corp., West Henrietta, NY). For US imaging, a dedicated breast scanning set up was developed consisting of a cone-shaped revolving water tank with a 152- mm-sized US transducer mounted in its wall and an aperture for needle insertion. With this setup, volumetric breast US data (0.5×0.5×0.5 mm3 voxel size) can be collected and reconstructed within 3 minutes. The position of the lesion as detected with breast CT was localized in the US data by rigid registration. After lesion localization, the tank rotates the transducer until the lesion is in the US plane. Since the lesion was visible on ultrasound, the performance of the registration was validated. To facilitate guided biopsy, the lesion motion, induced by needle insertion, is estimated using cross-correlation-based speckle tracking and the tracked lesion visualized in the US image at an update frequency of 10 Hz. Thus, in conclusion a fusion-based ultrasound-guided method was introduced which enables ultrasound-guided biopsy in breast that is applicable also for ultrasound occult lesions.
KEYWORDS: Transducers, Image quality, Ultrasonography, Data acquisition, 3D image reconstruction, 3D acquisition, Signal to noise ratio, Visualization, 3D image processing, Breast
Collecting high quality volumetric ultrasound (US) data using freehand scanning is challenging. The quality of the final 3DUS image is highly related to the applied scanning protocol and the subsequently used reconstruction method. The protocol should ensure the sonographer collects sufficient data of satisfactory quality for an accurate reconstruction.
In this study we developed a real-time reconstruction method that provides visual feedback during scanning. The feedback indicates the areas, of which the sonographer should collect more data. The method was tested by acquiring US data of a breast phantom in a setup mimicking freehand scanning which consisted of a linear transducer mounted in a translation stage that also allowed rotation.
To reconstruct the volume in real-time on a target grid of 0.5x0.5x0.5mm, we applied a simplified Voxel Nearest Neighbor (VNN) method, i.e., only the closest to B-mode plane voxels were updated. Furthermore, voxels were updated only when their projection on the B-mode plane was closer to the transducer surface than in the previous scan planes. Interpolation was performed within the acquired volume to fill in the holes where sufficient data were available. Sub-volumes with insufficient data were visualized in the reconstructed volume (update rate 50 Hz). This visual feedback can guide the sonographer during freehand scanning to improve the quality of the reconstructed 3DUS images. Cross-sections of the reconstructed data were compared to the independently acquired B-mode images and confirmed that our real-time method of low computational complexity provided accurate volumetric ultrasound images.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.