Superferromagnetic iron oxide (SFMIOs) is a new paradigm for Magnetic Particle Imaging (MPI) as it approaches the ideal imaging agent characteristics of a steep, step-like magnetization curve. Other than the expected 10-fold SNR and spatial resolution improvements from the square-like hysteresis curve, we demonstrate other unique qualities of SFMIOs that enable robust "chemical-shift-like" color multiplexing to potentially enable a range of magnetic "dyes" that work for at-depth imaging. We also demonstrate the extremely high sensitivity of SFMIO signal to the proximity of SFMIOs to each other, and explain how this could potentially be used as a FRET-like nanoscale ruler.
Magnetic fluid hyperthermia (MFH) is a promising avenue for noninvasive or minimally invasive therapies including tissue ablation, hyperthermia, and drug delivery. Magnetic particle imaging (MPI) is a promising new medical imaging modality with wide-ranging applications including angiography, cell tracking, and cancer imaging. MFH and MPI are kindred technologies leveraging the same physics: Both MFH and MPI function by exciting iron oxide magnetic nanoparticles with AC magnetic fields. In this manuscript, we show that this can be leveraged for combined MPI-MFH. The gradient fields employed in MPI can benefit MFH by providing high resolution targeting anywhere in the body, and a dual system provides opportunities for real-time diagnostic imaging feedback. Here we experimentally quantify the spatial localization of MFH using MPI gradient fields with a custom MPI-MFH system, demonstrating approximately 3 mm heating resolution in phantoms. We show an ability to precisely target phantom components as desired and provide heating of approximately 150 W g-1. We also show preliminary simultaneous MPI-MFH data.
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