Dr. Changhui Li Profile

Dr. Changhui Li

Associate Professor at Peking Univ

SPIE Involvement:

Conference Program Committee | Author

Area of Expertise:

Biomedical optics , medical imaging , computational electromagnetics , photoacoustic tomography , molecular imaging

Profile Summary

Changhui Li is an assistant professor of the Department of Biomedical at Peking University. He received his BS and MS degree in Peking University at 1997 and 2000, respectively. He got his PhD in Physics at 2006 from the Department of Physics at Texas A&M University. Dr. Li's research focuses on biomedical optics, functional and molecular imaging, and computational electromagnetics.

Publications (27)

SPIE Journal Paper | 26 September 2024 Open Access

Open Access

Image reconstruction from photoacoustic projections

Chao Tian, Kang Shen, Wende Dong, Fei Gao, Kun Wang, Jiao Li, Songde Liu, Ting Feng, Chengbo Liu, Changhui Li, Meng Yang, Sheng Wang, Jie Tian

PI, Vol. 3, Issue 03, R06, (September 2024) https://doi.org/10.1117/12.10.3788/PI.2024.R06

KEYWORDS: Image restoration, Reconstruction algorithms, Photoacoustic spectroscopy, Sensors, Photoacoustic tomography, Detection and tracking algorithms, Signal detection, Infrared imaging, Acoustics, Spherical lenses

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SPIE Journal Paper | 6 June 2024 Open Access

Open Access

Comprehensive framework of GPU-accelerated image reconstruction for photoacoustic computed tomography

Yibing Wang, Changhui Li

JBO, Vol. 29, Issue 06, 066006, (June 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.6.066006

KEYWORDS: Image restoration, Photoacoustic tomography, Reconstruction algorithms, Algorithm development, Data acquisition, Sensors, Computer hardware, 3D image reconstruction, Lithium, Detector arrays

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SPIE Journal Paper | 20 January 2024 Open Access

Open Access

Photoacoustic imaging of peripheral vessels in extremities by large-scale synthetic matrix array

Shuang Li, Guangjie Zhang, Yibing Wang, Wenzhao Li, Yu Sun, Changhui Li

JBO, Vol. 29, Issue S1, S11519, (January 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.S1.S11519

KEYWORDS: Imaging systems, Imaging arrays, Matrices, Photoacoustic imaging, 3D image processing, Stereoscopy, Light sources and illumination, Vascular imaging, Vascular diseases, Image restoration

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SPIE Journal Paper | 10 February 2023 Open Access

Open Access

Cable-free brain imaging for multiple free-moving animals with miniature wireless microscopes

Yangzhen Wang, Zhongtian Ma, Wenzhao Li, Feng Su, Chong Wang, Wei Xiong, Changhui Li, Chen Zhang

JBO, Vol. 28, Issue 02, 026503, (February 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.2.026503

KEYWORDS: Animals, Microscopes, Imaging systems, Brain imaging, Neurons, Batteries, Image quality, Video, Neuroimaging, Control systems

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Proceedings Article | 15 March 2018 Presentation

Presentation

Developing a real-time photoacoustic-ultrasound dual modality functional imaging system (Conference Presentation)

Fang Yang, Lingyi Zhao, Meng Yang, Lei Zhu, Xujin He, Changhui Li, Lianxi Xiang

Proceedings Volume 10494, 104940A (2018) https://doi.org/10.1117/12.2287788

KEYWORDS: Imaging systems, Signal detection, Ultrasonography, Optical parametric oscillators, Transducers, Functional imaging, Photoacoustic imaging, Multimodal imaging, Photoacoustic spectroscopy, 3D scanning

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Proceedings Article | 14 March 2018 Presentation

Presentation

Photoacoustic/ultrasound dual imaging of human superficial lesions: an initial clinical study (Conference Presentation)

Meng Yang, Yuxin Jiang, Lingyi Zhao, Na Su, Yao Wei, Ming Wang, Fang Yang, Changhui Li

Proceedings Volume 10487, 104870C (2018) https://doi.org/10.1117/12.2286872

KEYWORDS: Imaging systems, Tumors, Ultrasonography, Photoacoustic imaging, Breast, Oxygen, In vivo imaging, Laser sources, Doppler effect, Image fusion

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Objective: To develop dual-modality Photoacoustic(PA)/Ultrasound(US) system based on clinical US machine and performed imaging study of in vivo human superficial lesions. Methods: A dual-modality PA/US system was developed based on a high-end clinical US machine with a handheld probe for US/PA dual modality imaging, equipped with multi-wavelength laser source. Twenty-three patients were enrolled consecutively from the outpatients and inpatients of Peking Union Medical College Hospital (PUMCH) from Dec. 15th 2016 to Apr.15th 2017. All the patients underwent ultrasound examinations including both gray scale and color Doppler flow imaging ultrasound (CDFI) to evaluate the morphological and vascular information of the lesions. PA/US imaging was performed right after CDFI, the CDFI and the PA/US dual imaging information of each case were compared. Results: The laser source for PAI generates multi-wavelength laser pulses at 10Hz. Therefore, deoxyhemoglobin and hematoglobulin in tumor vasculature, which serve as different optical absorbers at specific wavelengths, can be evaluated and compared through PAI. PA/US dual modality imaging was performed in 23 cases, including 10 thyroid lesions, 10 breast lesions, and 3 soft tissue endometriosis lesions. All of the lesions performed surgery with pathology confirmed diagnosis. Our PA/US dual modality imaging system showed high quality gray scale ultrasonic and dual-modality fusion images. According to the results, significant differences exist between PAI and CDFI. PAI could reveal some blood vessels that were not sensitive for Doppler ultrasound. PAI proved the ability of imaging both the peripheral and intra-nodular vessels of human superficial lesions, as well as detecting the difference of oxygen saturation between benign and malignant tumor. Conclusion: Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound in superficial lesion examination, which has a great potential for clinical diagnosis.

Proceedings Article | 3 March 2017 Paper

Paper

Polarization-dependent optical reflection ultrasonic detection

Xiaoyi Zhu, Zhiyu Huang, Guohe Wang, Wenzhao Li, Changhui Li

Proceedings Volume 10064, 100641X (2017) https://doi.org/10.1117/12.2251079

KEYWORDS: Acoustics, Prisms, Reflection, Laser beam diagnostics, Polarization, Interfaces, Transducers, Sensors, Refractive index, Photoacoustic tomography, Ultrasonics

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SPIE Journal Paper | 12 May 2016 Open Access

Open Access

Noninvasively measuring oxygen saturation of human finger-joint vessels by multi-transducer functional photoacoustic tomography

Zijian Deng, Changhui Li

JBO, Vol. 21, Issue 06, 061009, (May 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.6.061009

KEYWORDS: Transducers, Acquisition tracking and pointing, Oxygen, Photoacoustic tomography, Lithium, Blood vessels, Signal detection, Image resolution, Ultrasonics, Imaging systems

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Proceedings Article | 17 September 2014 Paper

Paper

Developing a free-space fluorescence molecular tomography system

Yichen Ding, Xiaohui Zhai, Guohe Wang, Qiushi Ren, Changhui Li

Proceedings Volume 9230, 923022 (2014) https://doi.org/10.1117/12.2068919

KEYWORDS: Luminescence, Optical fibers, Fluorescence tomography, Tomography, Imaging systems, Lamps, Optical filters, Quartz, Data acquisition, Molecular imaging

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Proceedings Article | 17 September 2014 Paper

Paper

Dual-modal whole eye photoacoustic imaging

Ning Wu, Qiushi Ren, Changhui Li

Proceedings Volume 9230, 923023 (2014) https://doi.org/10.1117/12.2068963

KEYWORDS: Imaging systems, Eye, Image fusion, Iris, Retina, Ultrasonography, Signal to noise ratio, Photoacoustic imaging, In vivo imaging, Tissues

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SPIE Journal Paper | 28 July 2014 Open Access

Open Access

Viscous optical clearing agent for in vivo optical imaging

Zijian Deng, Lijia Jing, Ning Wu, Pengyu lv, Xiaoyun Jiang, Qiushi Ren, Changhui Li

JBO, Vol. 19, Issue 07, 076019, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.076019

KEYWORDS: Skin, Optical clearing, Optical imaging, In vivo imaging, Optical coherence tomography, Imaging systems, Tissue optics, Ultrasonics, Photoacoustic microscopy, Ultrasonography

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SPIE Journal Paper | 9 May 2014 Open Access

Open Access

Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography

Kun Wang, Jun Xia, Changhui Li, Lihong Wang, Mark Anastasio

JBO, Vol. 19, Issue 05, 056007, (May 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.5.056007

KEYWORDS: Photoacoustic tomography, Image restoration, Reconstruction algorithms, Principal component analysis, Image filtering, Transducers, Biological research, Imaging systems, Video, Linear filtering

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Proceedings Article | 3 March 2014 Paper

Paper

Low-rank matrix estimation-based spatio-temporal image reconstruction for dynamic photoacoustic computed tomography

Kun Wang, Jun Xia, Changhui Li, Lihong Wang, Mark Anastasio

Proceedings Volume 8943, 89432I (2014) https://doi.org/10.1117/12.2041850

KEYWORDS: Photoacoustic tomography, Image restoration, Reconstruction algorithms, Transducers, Image analysis, Imaging systems, Algorithm development, Data acquisition, CT reconstruction, Tomography

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SPIE Journal Paper | 9 July 2013 Open Access

Open Access

Acoustically penetrable optical reflector for photoacoustic tomography

Zijian Deng, Honghong Zhao, Qiushi Ren, Changhui Li

JBO, Vol. 18, Issue 07, 070503, (July 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.7.070503

KEYWORDS: Acquisition tracking and pointing, Ultrasonography, Transducers, Signal detection, Photoacoustic tomography, Reflectors, Ultrasonics, Acoustics, Imaging systems, Reflection

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Proceedings Article | 4 March 2013 Paper

Paper

Developing photoacoustic ocular imaging system

Shuoqi Ye, Ning Wu, Qiushi Ren, Changhui Li

Proceedings Volume 8581, 85811E (2013) https://doi.org/10.1117/12.2003002

KEYWORDS: Imaging systems, Eye, Tissues, Photoacoustic spectroscopy, Iris, Retina, Tissue optics, Absorption, Ultrasonography, Photoacoustic tomography

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Proceedings Article | 23 February 2012 Paper

Paper

In vivo imaging of small animal models by photoacoustic microscopy

Shuoqi Ye, Ran Yang, Jingwei Xiong, K. Kirk Shung, Qifa Zhou, Changhui Li, Qiushi Ren

Proceedings Volume 8223, 82230X (2012) https://doi.org/10.1117/12.907197

KEYWORDS: Animal model studies, Tissue optics, Biomedical optics, In vivo imaging, Imaging systems, Absorption, Tissues, Image resolution, Photoacoustic microscopy, Optical microscopes

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Proceedings Article | 18 February 2011 Paper

Paper

Photoacoustic tomography of water in biological tissue

Zhun Xu, Changhui Li, Lihong Wang

Proceedings Volume 7899, 789912 (2011) https://doi.org/10.1117/12.873415

KEYWORDS: Tissue optics, Tissues, Acquisition tracking and pointing, Photoacoustic tomography, Absorption, Photoacoustic spectroscopy, Imaging systems, Brain, Near infrared, In vivo imaging

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SPIE Journal Paper | 1 May 2010 Open Access

Open Access

Photoacoustic tomography of water in phantoms and tissue

Zhun Xu, Changhui Li, Lihong Wang

JBO, Vol. 15, Issue 03, 036019, (May 2010) https://doi.org/10.1117/12.10.1117/1.3443793

KEYWORDS: Absorption, Tissue optics, Acquisition tracking and pointing, Bioalcohols, Photoacoustic tomography, Tissues, Signal detection, Transducers, Lithium, Laser tissue interaction

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SPIE Journal Paper | 1 March 2010 Open Access

Open Access

Compressed sensing in photoacoustic tomography in vivo

Zijian Guo, Changhui Li, Liang Song, Lihong Wang

JBO, Vol. 15, Issue 02, 021311, (March 2010) https://doi.org/10.1117/12.10.1117/1.3381187

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, In vivo imaging, Data acquisition, Compressed sensing, Sensors, Reconstruction algorithms, Ultrasonics, Tomography, Wavelets

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Proceedings Article | 24 February 2010 Paper

Paper

Real-time monitoring of small animal cortical hemodynamics by photoacoustic tomography

Changhui Li, Andres Aquirre, John Gamelin, Anastasios Maurudis, Quing Zhu, Lihong Wang

Proceedings Volume 7564, 756427 (2010) https://doi.org/10.1117/12.842159

KEYWORDS: Acquisition tracking and pointing, Hemodynamics, Imaging systems, Photoacoustic tomography, Brain, Absorption, Photoacoustic spectroscopy, Real time imaging, Image resolution, In vivo imaging

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Proceedings Article | 11 February 2010 Paper

Paper

Compressed sensing in photoacoustic tomography with in vivo experiments

Zijian Guo, Changhui Li, Liang Song, Lihong Wang

Proceedings Volume 7564, 75640J (2010) https://doi.org/10.1117/12.841311

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, Data acquisition, In vivo imaging, CT reconstruction, Reconstruction algorithms, Tomography, Compressed sensing, Sensors, Ultrasonics

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SPIE Journal Paper | 1 January 2010 Open Access

Open Access

Real-time photoacoustic tomography of cortical hemodynamics in small animals

Changhui Li, Andres Aguirre, John Gamelin, Anastasios Maurudis, Quing Zhu, Lihong Wang

JBO, Vol. 15, Issue 01, 010509, (January 2010) https://doi.org/10.1117/12.10.1117/1.3302807

KEYWORDS: Acquisition tracking and pointing, Photoacoustic tomography, Hemodynamics, Ultrasonography, Absorption, In vivo imaging, Photoacoustic spectroscopy, Brain, Imaging systems, Pulsed laser operation

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SPIE Journal Paper | 1 March 2009 Open Access

Open Access

Photoacoustic tomography of the mouse cerebral cortex with a high-numerical-aperture-based virtual point detector

Changhui Li, Lihong Wang

JBO, Vol. 14, Issue 02, 024047, (March 2009) https://doi.org/10.1117/12.10.1117/1.3122365

KEYWORDS: Sensors, Transducers, Acquisition tracking and pointing, Ultrasonics, Photoacoustic tomography, Cerebral cortex, Image resolution, Signal detection, Signal to noise ratio, Ferroelectric polymers

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Proceedings Article | 25 February 2009 Paper

Paper

Novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography using carbon nanotubes (CNTs) as a dual contrast agent

Manojit Pramanik, Geng Ku, Changhui Li, Magdalena Swierczewska, Danielle Green, Balaji Sitharaman, Lihong Wang

Proceedings Volume 7177, 71772G (2009) https://doi.org/10.1117/12.809230

KEYWORDS: Breast, Single walled carbon nanotubes, Ultrasonography, Microwave radiation, Scanners, Breast cancer, Transducers, Tissues, Acquisition tracking and pointing, Antennas

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Proceedings Article | 25 February 2009 Paper

Paper

High-NA-based virtual point detectors for photoacoustic imaging

Changhui Li, Lihong Wang

Proceedings Volume 7177, 71770R (2009) https://doi.org/10.1117/12.808514

KEYWORDS: Transducers, Sensors, Ultrasonics, Acquisition tracking and pointing, Ferroelectric polymers, Signal detection, Tomography, Photoacoustic tomography, Image sensors, Ultrasonography

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Proceedings Article | 28 February 2008 Paper

Paper

Improving the image quality of photoacoustic tomography (PAT) by using a negative acoustic lens

Changhui Li, Geng Ku, Lihong Wang

Proceedings Volume 6856, 685623 (2008) https://doi.org/10.1117/12.763533

KEYWORDS: Transducers, Acoustics, Acquisition tracking and pointing, Signal detection, Ultrasonography, Photoacoustic tomography, Signal generators, Reconstruction algorithms, Signal to noise ratio, Image quality

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Proceedings Article | 28 February 2008 Paper

Paper

RF diffraction effect in RF-induced thermoacoustic tomography: calibration and distortion

Changhui Li, Geng Ku, Pramanik Manojit, Lihong Wang

Proceedings Volume 6856, 685612 (2008) https://doi.org/10.1117/12.763450

KEYWORDS: Calibration, Distortion, Tissues, Diffraction, Tomography, Signal detection, Numerical simulations, Dielectrics, Transducers, Acoustics

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Showing 5 of 27 publications

Conference Committee Involvement (10)

Photons Plus Ultrasound: Imaging and Sensing 2025

26 January 2025 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2024

28 January 2024 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2023

29 January 2023 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2022

23 January 2022 | San Francisco, California, United States

Photons Plus Ultrasound: Imaging and Sensing 2021

6 March 2021 | Online Only, California, United States

Showing 5 of 10 Conference Committees

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