Unspecified Christian Domes Profile

Christian Domes

at Leibniz-Institut fur Photonische Technologien eV

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Proceedings Article | 4 October 2024 Paper

UV Raman spectroscopy for therapeutic drug monitoring

Timea Frosch, Christian Domes, Jürgen Popp, Torsten Frosch

Proceedings Volume 13115, 1311505 (2024) https://doi.org/10.1117/12.3028022

KEYWORDS: Raman spectroscopy, Deep ultraviolet, Plasma, Ultraviolet radiation, Fluorescence, Raman scattering, Point-of-care devices, Surface enhanced Raman spectroscopy

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Therapeutic drug monitoring (TDM) at the point of care is of paramount significance in healthcare. It enables timely monitoring of drug concentrations in a patient's body-fluids, especially in the bloodstream, ensuring personalized dosing for optimal therapeutic outcomes while minimizing side effects and toxicity. TDM is crucial for treating sepsis patients, as their altered pharmacokinetics make accurate antibiotic dosing challenging. Additionally, they need quick dose adjustments to match evolving clinical needs. TDM ensures individually optimal antibiotic levels for best efficacy. Recently, we exploited the advantages of deep-UV Raman spectroscopy in drug sensing of antibiotics for TDM. Firstly, deep-UV excitation enhances the Raman scattering, which is particularly useful for compounds with weak Raman signals, including low concentrated drugs. Secondly, it effectively minimizes fluorescence interference, a common challenge in conventional Raman spectroscopy. This makes deep-UV excitation especially suitable for monitoring active ingredients, such as fluoroquinolones and β-lactam antibiotics, in body fluids like urine and plasma at clinically relevant concentrations. Therefore, deep-UV Raman spectroscopy holds significant potential as a tool for personalized antibiotic dosing through rapid TDM at the point of care.

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