Dr. Cong Deng Profile

Dr. Cong Deng

Senior Scientist at Univ of Dayton

SPIE Involvement:

Author

Proceedings Article | 13 March 2024 Presentation + Paper

A portable biosensing system using tapered fiber sensors utilizing mode interference

Chaminda Ranathunga, Cong Deng, Partha Banerjee, Casey Collet, Uttam Sinha

Proceedings Volume 12835, 1283507 (2024) https://doi.org/10.1117/12.3005681

KEYWORDS: Refractive index, Beam propagation method, Wave propagation, Cladding, Step index fibers, Fiber optics sensors, Biosensing, Waveguides, Simulations, Sensors

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SPIE Journal Paper | 12 July 2022

Practical tapered optical fiber system for in-situ label-free sensing of various antigens

Cong Deng, Chaminda Ranathunga, Partha Banerjee, Xuelian Chen, Jiang Zhong, Uttam Sinha

OE, Vol. 61, Issue 07, 074102, (July 2022) https://doi.org/10.1117/12.10.1117/1.OE.61.7.074102

KEYWORDS: Tapered optical fibers, Sensing systems, Fiber lasers, Optical engineering, Molecules, Sensors, Refractive index, LabVIEW, Proteins, Signal to noise ratio

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A practical tapered optical fiber (TOF) biosensing system was developed for label-free detection using antigen-antibody pairs with repeatable results and a very high degree of sensitivity. This was done by attaching molecular recognition agents to a tapered fiber surface for augmenting sensitivity and specificity of analyte. The entire system included three main parts: a tunable laser, a tapered fiber, and an optical detector. Light from an unpolarized tunable fiber laser was introduced into the tapered fiber from one end, and the transmitted intensity was detected by a photodetector. In the tapered fiber area, the evanescent electromagnetic field, which extends outside the fiber, was able to detect minute changes in the refractive index caused by antigen-antibody pairs. Recorded data was analyzed using an innovative Fourier analysis method to find phase changes, which are directly related to the biomolecular concentration coated on fiber, from which antibody-antigen concentrations are obtained. Two experiments were performed to confirm the concept using two very different agents. The first was the protein Interleukin-8 (IL-8). Repeatable results with a sensitivity of 10 pg/mL were achieved. The second was human coronavirus OC43 (HCoV-OC43), a surrogate viral particle for SARS-CoV-2, with a sensitivity of 50 viruses/mL. Critical sources of error were identified and addressed for the purpose of using the device for real clinical diagnosis in various real-life environments, where viruses can reside in water, phosphate-buffer solution, or saliva, the most popular three environments in real clinical diagnosis. Our device was designed according to the principle that only one specific kind of antibody and antigen can be combined together. The device demonstrated good accuracy to chosen analyte(s) tailored to specific applications and offered the potential to develop a point-of-care device used in clinics, as well as for detecting a variety of viruses and biocontaminants. The reproducibility of TOFs was confirmed through multiple fabrications and consistent results.

Proceedings Article | 20 February 2020 Paper

Tapered fiber sensor usable for head and neck cancer screening

Cong Deng, Karolyn Hansen, Joseph Haus, Partha Banerjee, Uttam Sinha

Proceedings Volume 11233, 112330Z (2020) https://doi.org/10.1117/12.2545323

KEYWORDS: Fiber optics sensors, Cancer, Molecules, Neck, Optical fibers, Phase shifts, Head, Signal to noise ratio, Refractive index, Biological research

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Proceedings Article | 7 June 2013 Paper

Nanowire metal-insulator-metal plasmonic devices

Joseph Haus, Li Li, Nkorni Katte, Cong Deng, Michael Scalora, Domenico de Ceglia, Maria Antonietta Vincenti

Proceedings Volume 8883, 888303 (2013) https://doi.org/10.1117/12.2022127

KEYWORDS: Metals, Diodes, Particles, Plasmonics, Nanostructures, Gold, Silver, Resonance enhancement, Surface plasmons, Nanowires

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Proceedings Article | 24 February 2006 Paper

Enhanced Cerenkov second-harmonic generation in patterned lithium niobate

Cong Deng, Joseph Haus, Andrew Sarangan, Aziz Mahfoud, Concita Sibilia, Michael Scalora, Aleksei Zheltikov

Proceedings Volume 6123, 61230N (2006) https://doi.org/10.1117/12.646952

KEYWORDS: Second-harmonic generation, Waveguides, Lithium niobate, Refractive index, Resonance enhancement, Waveguide modes, Nonlinear optics, Crystals, Photonic crystals, Phase matching

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Proceedings Article | 27 April 2000 Paper

New free-space multistage optical interconnection network and its matrix theory

Fengguang Luo, Mingcui Cao, Anjun Wan, Jun Xu, Xinjun Zhou, Cong Deng

Proceedings Volume 3952, (2000) https://doi.org/10.1117/12.384410

KEYWORDS: Switching, Optical interconnects, Optical networks, Data communications, Laser applications, Roads, Optical computing, Data processing, Binary data, Beam splitters

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Proceedings Article | 26 November 1999 Paper

Optoelectronic switching network with 2D optical fiber bundle array I/O access device

Fengguang Luo, Mingcui Cao, Qiaoyan Hu, Anjun Wan, Jun Xu, Cong Deng, Yuan-Zhong Xu

Proceedings Volume 3847, (1999) https://doi.org/10.1117/12.371245

KEYWORDS: Switching, Optical fibers, Optoelectronics, Optical arrays, Optoelectronic devices, Optical networks, Networks, Single mode fibers, Receivers, Tolerancing

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Proceedings Article | 12 November 1999 Paper

Crossover photonic switching network with CMOS/SEED smart pixel device and 2D optical fiber bundle array

Fengguang Luo, Mingcui Cao, Qiaoyan Hu, Anjun Wan, Jun Xu, Cong Deng, Deming Liu

Proceedings Volume 3896, (1999) https://doi.org/10.1117/12.370372

KEYWORDS: Switching, Optical fibers, Optical arrays, Receivers, Optical networks, Optoelectronic devices, Optoelectronics, Optical interconnects, Modulators, Logic

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