Prof. Duncan Graham Profile

Prof. Duncan Graham

at Univ of Strathclyde

SPIE Involvement:

Author

Publications (17)

Proceedings Article | 5 October 2023 Paper

Point of use SERS-based lateral flow test for pathogenic infections

Waleed Hassanain, Sian Sloan-Dennison, Julia Spoors, Christopher Johnson, Neil Keegan, Karen Faulds, Duncan Graham

Proceedings Volume 12654, 1265402 (2023) https://doi.org/10.1117/12.2675805

KEYWORDS: Raman spectroscopy, Proteins, Surface enhanced Raman spectroscopy, Antibodies, Spectrometers, Pathogens, Portability, Visualization, Microscopes, Signal intensity

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SPIE Journal Paper | 20 December 2016 Open Access

Ferric plasmonic nanoparticles, aptamers, and magnetofluidic chips: toward the development of diagnostic surface-enhanced Raman spectroscopy assays

Haley Marks, Po-Jung Huang, Samuel Mabbott, Duncan Graham, Jun Kameoka, Gerard Coté

JBO, Vol. 21, Issue 12, 127005, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.127005

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Particles, Magnetism, Nickel, Plasmonics, Raman spectroscopy, Iron, Silver, Nanolithography

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Proceedings Article | 22 April 2016 Presentation + Paper

Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering

Esmaeil Heydari, Samuel Mabbott, David Thompson, Duncan Graham, Jonathan Cooper, Alasdair Clark

Proceedings Volume 9721, 972105 (2016) https://doi.org/10.1117/12.2209108

KEYWORDS: Plasmonics, Nanoparticles, Scanning probe lithography, Gold, Silver, Biosensors, Target detection, Optical lithography, Colorimetry, Raman scattering

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Proceedings Article | 22 April 2016 Paper

Aptamer conjugated silver nanoparticles for the detection of interleukin 6

Andrea Locke, Nicole Norwood, Haley Marks, Monika Schechinger, George Jackson, Duncan Graham, Gerard Coté

Proceedings Volume 9724, 972412 (2016) https://doi.org/10.1117/12.2213896

KEYWORDS: Plasmonics, Proteins, Surface enhanced Raman spectroscopy, Nanoparticles, Silver, Particles, Raman spectroscopy, Absorbance, Optical testing, Dynamic light scattering

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Proceedings Article | 22 April 2016 Presentation + Paper

Comparison of Fe2O3 and Fe2CoO4 core-shell plasmonic nanoparticles for aptamer mediated SERS assays

Haley Marks, Samuel Mabbott, Po-Jung Huang, George Jackson, Jun Kameoka, Duncan Graham, Gerard Coté

Proceedings Volume 9722, 97220N (2016) https://doi.org/10.1117/12.2213735

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Particles, Magnetism, Raman spectroscopy, Silver, Plasmonics, Nanolithography, Microfluidics, Iron

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Proceedings Article | 12 March 2015 Paper

SERS active colloidal nanoparticles for the detection of small blood biomarkers using aptamers

Haley Marks, Samuel Mabbott, George Jackson, Duncan Graham, Gerard Cote

Proceedings Volume 9338, 93381C (2015) https://doi.org/10.1117/12.2078869

KEYWORDS: Nanoparticles, Surface enhanced Raman spectroscopy, Silver, Particles, Raman spectroscopy, Magnetism, Molecules, Blood, Nanolithography, Nanoprobes

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Functionalized colloidal nanoparticles for SERS serve as a promising multifunctional assay component for blood biomarker detection. Proper design of these nanoprobes through conjugation to spectral tags, protective polymers, and sensing ligands can provide experimental control over the sensitivity, range, reproducibility, particle stability, and integration with biorecognition assays. Additionally, the optical properties and degree of electromagnetic SERS signal enhancement can be altered and monitored through tuning the nanoparticle shape, size, material and the colloid’s local surface plasmon resonance (LSPR). Aptamers, synthetic affinity ligands derived from nucleic acids, provide a number of advantages for biorecognition of small molecules and toxins with low immunogenicity. DNA aptamers are simpler and more economical to produce at large scale, are capable of greater specificity and affinity than antibodies, are easily tailored to specific functional groups, can be used to tune inter-particle distance and shift the LSPR, and their intrinsic negative charge can be utilized for additional particle stability.1,2 Herein, a “turn-off” competitive binding assay platform involving two different plasmonic nanoparticles for the detection of the toxin bisphenol A (BPA) using SERS is presented. A derivative of the toxin is immobilized onto a silver coated magnetic nanoparticle (Ag@MNP), and a second solid silver nanoparticle (AgNP) is functionalized with the BPA aptamer and a Raman reporter molecule (RRM). The capture (Ag@MNP) and probe (AgNP) particles are mixed and the aptamer binding interaction draws the nanoparticles closer together, forming an assembly that results in an increased SERS signal intensity. This aptamer mediated assembly of the two nanoparticles results in a 100x enhancement of the SERS signal intensity from the RRM. These pre-bound aptamer/nanoparticle conjugates were then exposed to BPA in free solution and the competitive binding event was monitored by the decrease in SERS intensity.

Proceedings Article | 11 March 2015 Paper

An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events

Esmaeil Heydari, David Thompson, Duncan Graham, Jonathan Cooper, Alasdair Clark

Proceedings Volume 9340, 93400O (2015) https://doi.org/10.1117/12.2076915

KEYWORDS: Nanoparticles, Plasmonics, Silver, Surface enhanced Raman spectroscopy, Sensors, Scanning probe lithography, Nanostructures, Biosensing, Particles, Optical lithography

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Proceedings Article | 28 February 2014 Paper

ConA-based glucose sensing using the long-lifetime azadioxatriangulenium fluorophore

Brian Cummins, Jonathan Simpson, Zygmunt Gryczynski, Thomas Just Sørensen, Bo Laursen, Duncan Graham, David Birch, Gerard Coté

Proceedings Volume 8951, 89510A (2014) https://doi.org/10.1117/12.2039824

KEYWORDS: Glucose, Luminescence, Sensors, Proteins, Energy transfer, Blood, Atrial fibrillation, Fluorescence resonance energy transfer, Chemistry, Resonance energy transfer

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Proceedings Article | 18 September 2009 Paper

Methods for nanoparticle labeling of ricin and effect on toxicity

Alastair Wark, Jun Yu, Christopher Lindsay, Paola Nativo, Duncan Graham

Proceedings Volume 7486, 748604 (2009) https://doi.org/10.1117/12.833545

KEYWORDS: Nanoparticles, Toxicity, Gold, Proteins, Transmission electron microscopy, Molecules, Particles, Raman spectroscopy, Control systems, Biomedical optics

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Proceedings Article | 19 February 2009 Paper

DPN writing on non-flat gold surfaces and detection by SERS

Robert Stokes, Jennifer Dougan, Eleanore Irvine, Jenifer Ohayon, Sergey Rozhok, Tom Levesque, Bruce Dudzik, Mike Nelson, Duncan Graham

Proceedings Volume 7207, 720703 (2009) https://doi.org/10.1117/12.811523

KEYWORDS: Scanning probe lithography, Surface enhanced Raman spectroscopy, Gold, Raman spectroscopy, Plasmonics, Resonance enhancement, Raman scattering, Chemistry, Fluorescence spectroscopy, Molecules

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Proceedings Article | 18 February 2009 Paper

Sensitive molecular diagnostics using surface-enhanced resonance Raman scattering (SERRS)

Karen Faulds, Duncan Graham, Fiona McKenzie, Douglas MacRae, Alastair Ricketts, Jennifer Dougan

Proceedings Volume 7192, 719204 (2009) https://doi.org/10.1117/12.807051

KEYWORDS: Nanoparticles, Silver, Luminescence, Multiplexing, Raman spectroscopy, Resonance enhancement, Target detection, Statistical analysis, Fluorescence spectroscopy, Diagnostics

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Proceedings Article | 13 February 2009 Paper

Functionalised nanoparticles and SERRS for bioanalysis

Duncan Graham, David Thompson, Fiona Mckenzie, Karen Faulds, Ross Stevenson, Andrew Ingram, Robert Stokes, Emma McFarlane, James Alexander, Paul Garside, Axel Huber, Ian McInnes

Proceedings Volume 7192, 719202 (2009) https://doi.org/10.1117/12.810161

KEYWORDS: Nanoparticles, Silver, Gold, Raman spectroscopy, Resonance enhancement, Proteins, Absorbance, Plasmons, Sodium, Raman scattering

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Proceedings Article | 29 August 2008 Paper

Single and double stranded DNA detection using locked nucleic acid (LNA) functionalized nanoparticles

Fiona McKenzie, Robert Stokes, Karen Faulds, Duncan Graham

Proceedings Volume 7035, 70350J (2008) https://doi.org/10.1117/12.794965

KEYWORDS: Nanoparticles, Gold, Hydrogen, Silver, Target detection, Resonance enhancement, Temperature metrology, Head, Raman scattering, Surface plasmons

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Proceedings Article | 26 August 2008 Paper

Fabrication of biosensor arrays via DPN and detection by surface enhanced resonance Raman scattering

Robert Stokes, Jennifer Dougan, Eleanore Irvine, Jason Haaheim, Paul Stiles, Tom Levesque, Duncan Graham

Proceedings Volume 7032, 70320W (2008) https://doi.org/10.1117/12.794721

KEYWORDS: Scanning probe lithography, Resonance enhancement, Raman scattering, Chemistry, Plasmonics, Gold, Biosensors, Molecules, Luminescence, Raman spectroscopy

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Proceedings Article | 27 October 2006 Paper

Determining biomolecular structures by time-resolved fluorescence

Olaf Rolinski, Aaron Hernandez-Santana, Duncan Graham

Proceedings Volume 6047, 60472N (2006) https://doi.org/10.1117/12.710984

KEYWORDS: Fluorescence resonance energy transfer, Luminescence, Systems modeling, Molecules, Cobalt, Ions, Time resolved spectroscopy, Microelectromechanical systems, Molecular energy transfer, Spectroscopy

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Proceedings Article | 28 September 2006 Paper

Distance detection using Raman scattering: a new tagging technology

W. Smith, A. McCabe, G. McNay, D. Graham, N. Shand, B. Foulger

Proceedings Volume 6402, 64020L (2006) https://doi.org/10.1117/12.690832

KEYWORDS: Raman scattering, Silver, Luminescence, Raman spectroscopy, Resonance enhancement, Molecules, Chromophores, Metals, Laser scattering, Chemistry

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Proceedings Article | 18 June 2001 Paper

Detection of DNA and P-450s on silver colloidal nanoparticles by surface-enhanced resonance Raman scattering (SERRS)

W. Ewen Smith, Ewan Polwart, Clare McLaughlin, Benjamin Mallinder, Susan Smith, Duncan Graham

Proceedings Volume 4258, (2001) https://doi.org/10.1117/12.430763

KEYWORDS: Silver, Proteins, Raman scattering, Adsorption, Resonance enhancement, Raman spectroscopy, Particles, Nanoparticles, Molecules, Metals

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Showing 5 of 17 publications

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