We report the development of a novel methodology for patterning of nanostructured sensory materials using multi-dimensional
microstructured support platforms for optical bioimaging applications. Specifically, the support platforms
are fabricated using direct-write technique and sol-gel derived xerogel thin-films to form the sensor materials. This
creates a simple and versatile method for developing complex 3-D microstructures that have the combined capabilities of
biochemical sensing, microfluidic sample distribution for sensor arrays, and direct integration with Complimentary
Metal-Oxide Semiconductor (CMOS) Integrated Circuits (ICs) used for sensor signal detection and processing. More
importantly, this methodology would enable the development of large-scale arrayed sensing platforms for applications in
cell-culture analysis and tissue imaging. The configuration and fabrication of the proposed microstructures, which
consist of planar ridge and hollow waveguides, will be described in detail. As a prototype implementation, we
demonstrate direct-write ridge waveguide support structures coated with luminophore-doped xerogels that are responsive
to gaseous oxygen (O2) concentration.
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