KEYWORDS: Skin, Absorption, Melanoma, Diffuse reflectance spectroscopy, Scattering, Optical properties, In vivo imaging, Tissue optics, Spectroscopy, Monte Carlo methods
In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength range of 455-765 nm for 144 pigmented skin lesions including 16 melanomas. The absorption and reduced scattering spectra were found to change with the malignancy of the skin lesions, which were generally higher for the malignant cases than the benign ones. Based on the measurement results, the physiological origin leading to the change of the absorption and scattering properties is also discussed.
This paper presents a study for in-vivo estimation of optical properties of pigmented skin tumor by oblique incidence
diffuse reflectance spectroscopy. The developed system has been tested in clinical conditions to compare the optical
properties of melanomas, dysplastic nevi and common nevi. The
spatio-spectral data are collected in the wavelength
range of 455 to 765 nm from 96 pigmented skin lesions including 10 histopathologically diagnosed as melanoma, 67 as
dysplastic nevi and 19 lesions as common nevi. The preliminary results indicate significantly larger average reduced
scattering coefficient spectra for malignant and dysplastic lesions than for benign common nevi.
A study of in-vivo classification of pigmented skin lesions using oblique-incidence diffuse reflectance spectroscopy
is presented. Spatio-spectral data in the wavelength range from 455 to 765 nm are collected from 111 pigmented
lesions including 10 histopathologically diagnosed as melanoma. The first 67 lesions are used for training the
classifiers, and 44 lesions are used for testing. The first classifier separates (1) malignant melanoma and severe
dysplastic nevi from (2) moderate and mild dysplastic nevi, common nevi, actinic and seborrheic keratoses. The
second classifier next distinguishes between (a) moderate and mild dysplastic nevi, common nevi from (b) actinic
and seborrheic keratoses. The third classifier further separates (I) moderate and mild dysplastic nevi from (II)
common nevi. The first classifier performs with 100% sensitivity and 91% specificity with overall classification
rates of 93% and 95 % for the training and testing sets, respectively. The second classifier has classification rates of
95% and 97 % for the training and testing sets, respectively, whereas the third classifier has classification rates of
98% and 94 % for the training and testing sets, respectively.
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