Dr. Frank Koenig Profile

Dr. Frank Koenig

at Klinik Hygiea

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Publications (6)

Proceedings Article | 22 June 2005 Paper

Ex vivo and in vivo topographic studies of bladder by optical coherence tomography

Dmitri Daniltchenko, Markus Sachs, Eva Lankenau, Frank Koenig, Mick Burkhardt, Gereon Huettmann, Glen Kristiansen, Dietmar Schnorr, Salman Al-Shukri, Stefan Loening

Proceedings Volume 5771, (2005) https://doi.org/10.1117/12.634810

KEYWORDS: Optical coherence tomography, Bladder, In vivo imaging, Tissue optics, Spatial resolution, LASIK, Diagnostics, Laser development, Tumors, Endoscopes

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Conventional imaging modalities like CT or ultrasonography have a spatial resolution of 70-1000 rim. OCT is a new method by which light of a certain wavelength is introduced into a fiberglass optic to measure tissue structures of up to 2.5 mm depth with a spatial resolution of up to 10-15 μm. We utilized the Tomograph Sirius 713, developed at the Medical Laser Centre in cooperation with 4-Optics AG, Lubeck, Germany. This apparatus uses a special Super- Luminescence-Diode (SLD) that produces light within the near infrared wavelength, with a central wavelength of 1300 nm. The coherence length is reduced to 15 μm. The light is introduced into a fiberglass optic which is several meters long and is easy to handle. To measure the depth of invasion and position of urothelial bladder tumors, the fiberglass optic is attached to a regular endoscope (Wolf, Knittlingen, Germany) via an OCT adapter. That way, in parallel to the regular endoscopic view of the bladder mucosa with or without pathologic findings, an OCT picture of the superficial as well as the deeper muscle layers is visible online. OCT was used to obtain 945 images from the bladder in vivo und ex vivo of 65 patients. OCT of normal bladder mucosa allows to image a cross section of up to 2.5 mm. It is possible to distinguish transitional epithelium, lamina propria, smooth muscles and capillaries. In cystitis, the thickness of the mucosa is constant, but the distinction between the different layers is blurred. In squamous metaplasia there is thickening of the epithelial layer, with preservation of lamination of the lower layers. In transitional cell carcinoma there is a complete loss of the regular layered structure. It is easily possible to distinguish the border between tumour and normal bladder tissue. OCT is a new high-resolution imaging procedure. It has the potential to improve the diagnostics of the urothelium and its lesions. In conjunction with a highly sensitive orientating procedure like fluorescence-cystoscopy, intraoperative staging of these changes could be possible in the future.

Proceedings Article | 20 August 2004 Paper

Confocal reflectance imaging of excised malignant human bladder biopsies

Dmitri Daniltchenko, Albrecht Kastein, Frank Koenig, Markus Sachs, Dietmar Schnorr, Salman Al-Shukri, Stefan Loening

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578348

KEYWORDS: Bladder, Tumors, Biopsy, Confocal microscopy, Curium, Reflectivity, Tissues, Bladder cancer, Image resolution, Microscopy

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Proceedings Article | 1 July 2004 Paper

In vivo optical coherence tomography in endoscopic diagnostics of bladder disease

Dmitri Daniltchenko, Eva Lankenau, Frank Konig, Brian Shay, Gereon Huettmann, Markus Sachs, Dietmar Schnorr, Stefan Loening

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.530207

KEYWORDS: Optical coherence tomography, Bladder, Tumors, Endoscopy, Tissues, Tissue optics, Capillaries, Video, In vivo imaging, Endoscopes

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Proceedings Article | 1 July 2004 Paper

Dispersion compensation for proximal scanning rigid OCT endoscopes

Eva Lankenau, Matthias Schumacher, Peter Koch, Frank Konig, Dmitri Daniltchenko, Dietmar Schnorr, Gereon Huettmann

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.531312

KEYWORDS: Optical coherence tomography, Endoscopes, Dispersion, Interferometers, Endoscopy, Bladder, Single mode fibers, Scanners, Quartz, Refraction

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Proceedings Article | 13 October 2003 Paper

The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis of urinary bladder cancer

Dmitri Daniltchenko, Frank Koenig, Dietmar Schnorr, Alexander Valdman, Salman Al-Shukri, Stefan Loening

Proceedings Volume 5068, (2003) https://doi.org/10.1117/12.518629

KEYWORDS: Luminescence, Bladder, Cystoscopy, Visualization, Bladder cancer, Diagnostics, Biopsy, Endoscopy, Fluorescence spectroscopy, Tissues

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Proceedings Article | 12 September 2003 Paper

Fluorescence endoscopy with 5-amino levulinic acid (ALA) reduces early recurrence rate in superficial bladder cancer

Frank Koenig, Claus Riedl, Dmitri Daniltchenko, Dietmar Schnorr

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476386

KEYWORDS: Tumors, Luminescence, Endoscopy, Bladder cancer, Bladder, Cystoscopy, Surgery, Diagnostics, Dielectrophoresis, Astatine

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Showing 5 of 6 publications

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