Prof. Gunay Basar Profile

Prof. Gunay Basar

at Istanbul Technical Univ

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 4 March 2019 Presentation

Raman spectroscopy as a diagnostic method for endometriosis disease (Conference Presentation)

Medine Tuna Pesen, Gunay Basar, Ugur Parlatan, Bahar Yuksel, Engin Oral, Ercan Bastu, Mehmet Burçin Ünlü

Proceedings Volume 10890, 108901P (2019) https://doi.org/10.1117/12.2506997

KEYWORDS: Raman spectroscopy, Diagnostics, Blood, Laparoscopy, Proteins, Principal component analysis, Uterus, Molecules, Spectroscopy, Molecular spectroscopy

Read Abstract +

Endometriosis is a condition in which the endometrium grows outside of the uterus. One of its severe effects is that it may cause infertility. Investigating only the symptoms of the disease is insufficient for the diagnosis. The correct and the exact diagnosis can be done by laparoscopy. During the disease the amount of molecules such as lipids, proteins and some antigens (i.e. CA125) in the blood serum changes. Raman spectroscopy is a vibrational spectroscopy technique which can analyze specific spectral patterns, substances and molecular changes with high specificity. In this study, Raman spectroscopy has been used as a tool for detecting the changes in blood serum contents for diagnosis of endometriosis. In our study, the Raman spectra of blood sera of 49 patients with 45 healthy women have been compared. Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) methods are used in the analysis. The results indicated that 1003 cm-1 Raman band (phenylalanine) decreased for the women with endometriosis. In addition, a decrease in 1448 cm-1 band shows that the total amount of proteins decreased. The changes in the bands at 1155 and 1521 cm-1 imply that the amount of carotenoids diminished during the disease which is an expected effect of endometriosis. According to the analysis results, the sensitivity and the specificity of the Raman spectroscopy analysis were found to be 98.8% and 91.0% respectively for the detection of endometriosis. As a complementary method to laparoscopy, Raman spectroscopy can be used for diagnosis of endometriosis.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years