Differences in hydroxypropyl cellulose (HPC) include the degree of hydroxypropyl substitution of cellulose or the molecular weight of hydroxypropyl cellulose. The differences have an impact not only on its physicochemical properties but also on the drug delivery process. It is sensitive to a wide range of intermolecular vibrations as well as lattice phonons using Terahertz time-domain spectroscopy (THz-TDS). We have obtained the spectral parameters of various kinds of hydroxypropyl celluloses by THz-TDS measurement. The experimental results show that the spectral characteristics of various kinds of hydroxypropyl celluloses are distinguishable. Using THz-TDS, we can quickly and accurately distinguish different hydroxypropyl celluloses and analyze the physicochemical properties of different hydroxypropyl celluloses.
In recent years, Terahertz time-domain spectroscopy(THz-TDS), as a new spectral analysis method, has become a hot research. Terahertz time-domain spectroscopy can acquire spectral data with high SNR over a board range of THz frequencies. Terahertz technology has been widely used in the quality control of traditional Chinese medicine. In this paper, Terahertz time-domain spectroscopy combined with chemometrics was used to analyze the differences between two kinds of medicines-Bailing capsules and Jinshuibao capsules. The time-domain signal of the samples can be obtained by THz-TDS. And the refractive index and absorption coefficient of samples can be calculated. The PCA scores of 2Dplots (PC1×PC2) of Bailing and Jinshuibao capsules were obtained through principal component analysis(PCA), and the cumulative contribution rate of the first two principal components exceeds 98%. Their absorption coefficients were used as the characteristic data of cluster analysis. Euclidean distance was used to cluster and identify the samples. The results shows that twenty different batches of TCM were divided into two categories, with a slight crossover in the middle. The clustering precision of Jinshuibao capsules is 100%, while the clustering precision of Bailing capsules is 81. 8%. The results show that the clustering method can effectively analyze the terahertz time-domain spectrum of traditional Chinese medicine.
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