Dr. Lida Zhu Profile

Dr. Lida Zhu

at Santec Corp

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 13 March 2024 Poster

Multiple scattering suppression for in vivo OCT measurement by B-scan-wise-multi-focus averaging method

Yiqiang Zhu, Lida Zhu, Shuichi Makita, Yiheng Lim, Yu Guo, Yoshiaki Yasuno

Proceedings Volume PC12830, PC1283013 (2024) https://doi.org/10.1117/12.3003699

KEYWORDS: Optical coherence tomography, In vivo imaging, Multiple scattering, Signal processing, Tunable filters, Tissues, Statistical analysis, Signal intensity, Scattering, Image resolution

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Proceedings Article | 13 March 2024 Poster

Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches

Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, Yoshiaki Yasuno

Proceedings Volume PC12830, PC128301E (2024) https://doi.org/10.1117/12.3005612

KEYWORDS: Optical coherence tomography, Computing systems, Tissues, Image resolution, Visualization, Spectral resolution, Numerical simulations, Modeling, Diffusion, Breast

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Proceedings Article | 13 March 2024 Presentation

Wavelength and resolution dependency of dynamic optical coherence tomography

Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, Yoshiaki Yasuno

Proceedings Volume PC12854, PC128540D (2024) https://doi.org/10.1117/12.3001490

KEYWORDS: Optical coherence tomography, Tissues, Image resolution, Computing systems, Visualization, Spectral resolution, Numerical simulations, Modeling, Diffusion, Breast cancer

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Proceedings Article | 16 March 2023 Presentation

Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Pradipta Mukherjee, Roxane Licandro, Lida Zhu, Tomoko Mori, Rion Morishita, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Satoshi Matsusaka, Martin Distel, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC12391, PC123910Z (2023) https://doi.org/10.1117/12.2646760

KEYWORDS: Optical coherence tomography, Tumors, Prototyping, Polarization, 3D modeling, 3D image processing, Tumor growth modeling, Image resolution, Visualization, Tissues

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Proceedings Article | 9 March 2023 Presentation

Motion-immune digital refocusing of point-scanning optical coherence tomography using Lissajous scan for in vivo imaging

Shuichi Makita, Lida Zhu, Pradipta Mukherjee, Yiheng Lim, Rion Morishita, Ibrahim Abd El-Sadek, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123670M (2023) https://doi.org/10.1117/12.2647850

KEYWORDS: Optical coherence tomography, In vivo imaging, Tissues, Electronic filtering, Ultrafast phenomena, Ultrafast imaging, Statistical analysis, Spatial resolution, Skin, Reconstruction algorithms

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Proceedings Article | 8 March 2023 Poster + Paper

B-scan-wise multi-focus averaging method to suppress multiple scattering signal

Yiqiang Zhu, Lida Zhu, Shuichi Makita, Yiheng Lim, Yoshiaki Yasuno

Proceedings Volume 12367, 1236713 (2023) https://doi.org/10.1117/12.2652555

KEYWORDS: Optical coherence tomography, Scattering, Multiple scattering, Glasses, Particles, Tissues, In vivo imaging, Image acquisition, Computation time, 3D acquisition

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Proceedings Article | 8 March 2023 Presentation + Paper

Multiple scattering suppression by multi-focus averaging in Jones-matrix optical coherence tomography

Lida Zhu, Shuichi Makita, Yiheng Lim, Junya Tamaoki, Yiqiang Zhu, Makoto Kobayashi, Yoshiaki Yasuno

Proceedings Volume 12367, 123670E (2023) https://doi.org/10.1117/12.2652183

KEYWORDS: Optical coherence tomography, Scattering, Biological samples, Polarization, Multiple scattering, Modulation, Tissues

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Optical coherence tomography (OCT) has been utilized to investigate the optical properties of tissue in animal model studies. Polarization sensitive OCT (PS-OCT) is one of the functional extensions of OCT, which provides additional contrasts such as birefringence and degree-of-polarization uniformity (DOPU). It enables multi-contrast imaging for discrimination of tissue properties in biological samples. However, biological samples often exhibit multiple scattering (MS). It severely hampers the penetration depth and degrades the optical property measurement in deep regions for both OCT and PS-OCT. In a recently presented work, it was found that all of the scattering OCT value, birefringence value, and DOPU value were altered if they were measured at the deep region. This alteration is suspected to be artifacts caused by MS. So far, various methods have been proposed to tackle the MS issue. One is averaging several images with decorrelated MS signals. The decorrelation of MS signals was realized by wavefront shaping with complex devices such as spatial light modulators or deformable mirrors. However, these optics increase the cost and system complexity, and the wavefront shaping is still challenging. Simple hardware, such as multimode fiber, was only demonstrated in full-field OCT. In this work, we present a method termed as “multi-focus averaging” (MFA) to suppress the MS effect and improve the image contrast in deep regions of scattering samples. It uses focus modulation by a tunable lens to decorrelate MS signals among multiple acquisitions, and computational refocusing is used to cancel the different defocus during focus modulation. The refocused OCT signals are averaged in complex to reduce MS signals. It is demonstrated in standard OCT scheme, and a scattering phantom and a post-mortem zebrafish are used to validate the intensity contrast improvement. Results show that MFA images can provide better intensity contrast than standard complex averaging in scattering samples. In addition, we further adapt this method to PS-OCT to suppress the MS and to improve the accuracy of polarization sensitive measurement. We found MFA mitigated low-DOPU artifact in polarization sensitive measurement.

Proceedings Article | 3 October 2022 Presentation

Longitudinal xenograft zebrafish investigation using polarization-sensitive Jones-matrix optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Tomoko Mori, Pradipta Mukherjee, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume 12223, 122230F (2022) https://doi.org/10.1117/12.2632878

KEYWORDS: Optical coherence tomography, Polarization, Tumors, Tumor growth modeling, Tissue optics, Scattering, Prototyping, Genetics, Cancer, Breast cancer

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Multi-focus average for multiple scattering noise suppression in optical coherence tomography

Lida Zhu, Shuichi Makita, Antonia Litchtenegger, Junya Tamaoki, Kensuke Oikawa, Pradipta Mukherjee, Yiheng Lim, Makoto Kobayashi, Jiajie Luo, Yoshiaki Yasuno

Proceedings Volume 11948, 119480M (2022) https://doi.org/10.1117/12.2609190

KEYWORDS: Optical coherence tomography, Scattering, Multiple scattering, Tissues, Light scattering

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Proceedings Article | 7 March 2022 Presentation + Paper

Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, Bernhard Baumann

Proceedings Volume 11948, 119480D (2022) https://doi.org/10.1117/12.2606982

KEYWORDS: Tumors, Polarization, Birefringence, Optical coherence tomography, Eye, Brain, Nondestructive evaluation, Photomicroscopy, Scattering, Tissues

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Motion-immune digital refocusing of point-scanning optical coherence tomography with Lissajous scan

Shuichi Makita, Lida Zhu, Kensuke Oikawa, Yoshiaki Yasuno

Proceedings Volume 11948, 119480F (2022) https://doi.org/10.1117/12.2609797

KEYWORDS: Optical coherence tomography, Aberration correction, In vivo imaging, Convolution, Signal processing, Tissues, Reconstruction algorithms

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Proceedings Article | 7 March 2022 Presentation

Three-dimensional intracellular motility imaging in non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno

Proceedings Volume PC11948, PC119480S (2022) https://doi.org/10.1117/12.2611984

KEYWORDS: Liver, Optical coherence tomography, 3D image processing, Tissues, 3D modeling, Volume rendering, Visualization, Imaging systems, Visual process modeling, Particles

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Proceedings Article | 7 March 2022 Presentation

Depth-of-focus extended multi-contrast imaging by polarization-sensitive optical coherence tomography

Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Antonia Lichtenegger, Martin Distel, Yoshiaki Yasuno

Proceedings Volume PC11963, PC119630I (2022) https://doi.org/10.1117/12.2609200

KEYWORDS: Tissues, Optical coherence tomography, Image resolution, Optical imaging, Birefringence, Scattering, Polarization, Collagen, 3D image processing

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Proceedings Article | 2 March 2022 Presentation + Paper

Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy

Pradipta Mukherjee, Shinchi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Tetsuro Oshika, Yoshiaki Yasuno

Proceedings Volume 11972, 1197208 (2022) https://doi.org/10.1117/12.2608443

KEYWORDS: Kidney, Tissues, Optical coherence tomography, Visualization, Imaging systems, Optical coherence microscopy, Tissue optics, Mouse models, Visual process modeling, Photomicroscopy

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Proceedings Article | 2 March 2022 Presentation

Non-invasive, structural and functional imaging of in vivo zebrafish in various development stages using Jones matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC11972, PC119720P (2022) https://doi.org/10.1117/12.2606979

KEYWORDS: Optical coherence tomography, In vivo imaging, Polarization, Functional imaging, Visualization, Prototyping, Eye, Birefringence, 3D image processing, Tumor growth modeling

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SPIE Journal Paper | 21 January 2022 Open Access

Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lixuan Bian, Lida Zhu, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

JBO, Vol. 27, Issue 01, 016001, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.016001

KEYWORDS: Birefringence, Optical coherence tomography, In vivo imaging, Scattering, Polarization, Signal attenuation, Prototyping, Eye, Spinal cord, Skin

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Proceedings Article | 9 December 2021 Paper

Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation

Yoshiaki Yasuno, Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Tzu-Wei Shen, Thitiya Seesan, Lida Zhu, Daisuke Oida, Kensuke Oikawa, Shuichi Makita, Shinichi Fukuda, Toshiharu Yamashita, Pradipta Mukherjee, Tetsuro Oshika, Prathan Branasiri, Satoshi Matsusaka

Proceedings Volume 11924, 119240H (2021) https://doi.org/10.1117/12.2616034

KEYWORDS: Tissues, Optical coherence tomography, Birefringence, Tumors, Tissue optics, Optical coherence microscopy, In vitro testing, Polarization, Liver, Visualization

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Proceedings Article | 8 March 2021 Presentation + Paper

Multi-contrast imaging with computational refocusing in polarization-sensitive optical coherence tomography

Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Yoshiaki Yasuno

Proceedings Volume 11630, 1163020 (2021) https://doi.org/10.1117/12.2582764

KEYWORDS: Optical coherence tomography, Birefringence, Polarization, Tissues, Silicon, Resolution enhancement technologies, Image resolution, Foam, Biological research, 3D image processing

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Optical coherence tomography (OCT) has been widely used for imaging biological sample due to its capability of three-dimensional (3-D) reconstruction. Recently, polarization-sensitive optical coherence tomography (PSOCT) has been used to investigate polarization properties of samples such as retina and muscle [1,2]. Such extensions provide additional contrasts other than traditional reflected intensity and offer a 3-D multi-functional reconstruction of materials and biological tissue. PS-OCT uses A-scan wise computation to obtain the polarization properties from a set of OCT images. In this computation, the lateral resolution is implicitly assumed as infinitely high. However, the birefringence measurement itself will be affected by the lateral optical resolution, defocus, and aberrations. One simple way to obtain high-resolution birefringent data is to use an objective with higher NA. However, OCT also suffers from the trade-off between the lateral resolution and the depth-of-focus (DOF), which might limit its application in thick samples. There have been various methods to overcome this issue. Hardware solutions such as mechanical depth scanning [3] have been reported, but the additional configurations would increase the complexity of system. On the other hand, computational methods do not require additional hardware set-up and thus can be easily adopted, such as interferometric synthetic aperture microscopy (ISAM) [4] and forward model based computational refocusing [5]. However, to our acknowledgement, there are only few reports of long imaging depth for 3-D birefringence imaging. One presented work combined the ISAM with PS-OCT [6]. But the impact of refocusing on multi-contrast imaging, such as artifact in birefringence measurement, has not been thoroughly investigated. In this paper, we present a DOF extended polarization-sensitive imaging by applying computational refocusing to Jones-matrix based PS-OCT (JM-OCT). Computational refocusing is applied to each of four polarization channels (images) of JM-OCT, and the birefringence and degree-of-polarization-uniformity (DOPU) images are computed from the refocused OCT images. Enhanced lateral resolution away from the focus plane and hence extended DOF are demonstrated through phantom and ex vivo porcine muscle measurements. The ex vivo porcine muscle measurement also suggests that the refocusing may reduce the birefringence artifacts.

Proceedings Article | 15 June 2020 Paper

Numerical jitter estimation for swept source optical coherence tomography

Lida Zhu, Arata Miyazawa, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Kensuke Oikawa, Daisuke Oida, Yoshiaki Yasuno

Proceedings Volume 11521, 115210T (2020) https://doi.org/10.1117/12.2573281

KEYWORDS: Optical coherence tomography, Holography, Polarization, 3D metrology, 3D acquisition, Algorithm development, Computational imaging, Computing systems, Biological research, Volume holography

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Showing 5 of 19 publications

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