Prof. Lun-De Liao Profile

Prof. Lun-De Liao

Principal Investigator at National Health Research Institutes

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Author

Publications (14)

SPIE Journal Paper | 1 November 2022 Open Access

Revisiting the cerebral hemodynamics of awake, freely moving rats with repeated ketamine self-administration using a miniature photoacoustic imaging system

Yuhling Wang, Chia-Hua Tsai, Tsung-Sheng Chu, Yun-Ting Hung, Mei-Yi Lee, Hwei-Hsien Chen, Li-Tzong Chen, Tzong-Rong Ger, Yung-Hsuan Wang, Nai-Jung Chiang, Lun-De Liao

NPh, Vol. 9, Issue 04, 045003, (November 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.4.045003

KEYWORDS: Blood vessels, Hemodynamics, Video, Imaging systems, Brain, Veins, Neurophotonics, Neuroimaging, Transducers, Miniature imaging systems

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SPIE Journal Paper | 4 October 2017 Open Access

Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model

Yu-Hang Liu, Su Jing Chan, Han-Chi Pan, Aishwarya Bandla, Nicolas K. K. King, Peter Tsun Hon Wong, You-Yin Chen, Wai Hoe Ng, Nitish Thakor, Lun-De Liao

NPh, Vol. 4, Issue 04, 045002, (October 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.4.045002

KEYWORDS: Ischemia, Hemodynamics, Electrodes, Brain, Sensors, Blood vessels, Blood, Neurons, Neurophotonics, Animal model studies

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SPIE Journal Paper | 29 September 2017 Open Access

Neurovascular function recovery after focal ischemic stroke by enhancing cerebral collateral circulation via peripheral stimulation-mediated interarterial anastomosis

Han-Chi Pan, Lun-De Liao, Yu-Chun Lo, Jia-Wei Chen, Han-Lin Wang, Li Yang, Yao-Wen Liang, Po-Yu Huang, Ming-Hsun Yang, You-Yin Chen

NPh, Vol. 4, Issue 03, 035003, (September 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.3.035003

KEYWORDS: Brain, Laser speckle contrast imaging, Ischemic stroke, Blood circulation, Tissues, Speckle, Blood, Chromium, Ischemia, Electrodes

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Proceedings Article | 8 February 2017 Paper

Real-time imaging for cerebral ischemia in rats using the multi-wavelength handheld photoacoustic system

Yu-Hang Liu, Yu Xu, Kim Chuan Chan, Kalpesh Mehta, Nitish Thakor, Lun-De Liao

Proceedings Volume 10051, 100510W (2017) https://doi.org/10.1117/12.2251775

KEYWORDS: Imaging systems, Ischemia, Real time imaging, Photoacoustic spectroscopy, Brain, Hemodynamics, In vivo imaging, Point spread functions, Lead, Blood vessels

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SPIE Journal Paper | 19 June 2014 Open Access

Improving neurovascular outcomes with bilateral forepaw stimulation in a rat photothrombotic ischemic stroke model

Lun-De Liao, Aishwarya Bandla, Ji Min Ling, Yu-Hang Liu, Li-Wei Kuo, You-Yin Chen, Nicolas KK King, Hsin-Yi Lai, Yan-Ren Lin, Nitish Thakor

NPh, Vol. 1, Issue 01, 011007, (June 2014) https://doi.org/10.1117/12.10.1117/1.NPh.1.1.011007

KEYWORDS: Imaging systems, Electrodes, Ischemic stroke, Hemodynamics, Sensors, Brain, Neurophotonics, Signal processing, Injuries, Ultrasonics

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Proceedings Article | 4 March 2013 Paper

Functional photoacoustic micro-imaging of cerebral hemodynamic changes in single blood vessels after photo-induced brain stroke

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Meng-Lin Li

Proceedings Volume 8581, 858133 (2013) https://doi.org/10.1117/12.2003543

KEYWORDS: Blood vessels, Hemodynamics, Brain, In vivo imaging, Ischemic stroke, Ultrasonics, Electrodes, Transducers, Photoacoustic microscopy, Blood

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SPIE Journal Paper | 7 May 2012 Open Access

Investigation of the cerebral hemodynamic response function in single blood vessels by functional photoacoustic microscopy

Lun-De Liao, Chin-Teng Lin, Hsin-Yi Lai, Jyh-Yeong Chang, You-Yin Chen, Yen-Yu Shih, Timothy Duong, Wan-Ting Zhao, Meng-Lin Li

JBO, Vol. 17, Issue 6, 061210, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.6.061210

KEYWORDS: Blood vessels, Hemodynamics, Blood, Photoacoustic microscopy, Brain, Functional magnetic resonance imaging, Transducers, Signal detection, Neuroimaging, Ultrasonics

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Proceedings Article | 23 February 2012 Paper

Functional photoacoustic micro-imaging of rat cerebral hemodynamic response function in single vessels during forepaw electrical stimulation

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Jyh-Yeong Chang, Meng-Lin Li

Proceedings Volume 8223, 822334 (2012) https://doi.org/10.1117/12.908131

KEYWORDS: Hemodynamics, Blood vessels, Ultrasonics, Transducers, Photoacoustic spectroscopy, Photoacoustic microscopy, Blood, In vivo imaging, Oxygen, Spatial resolution

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Proceedings Article | 19 February 2011 Paper

Functional transcranial photoacoustic micro-imaging of mouse cerebrovascular cross-section and hemoglobin oxygenation changes during forepaw electrical stimulation

Lun-De Liao, You-Yin Chen, Chin-Teng Lin, Jyh-Yeong Chang, Meng-Lin Li

Proceedings Volume 7899, 78992X (2011) https://doi.org/10.1117/12.874449

KEYWORDS: Ultrasonics, Absorption, Skull, Transducers, Hemodynamics, Photoacoustic spectroscopy, In vivo imaging, Ultrasonography, Signal to noise ratio, Somatosensory cortex

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Proceedings Article | 24 February 2010 Paper

In vivo functional photoacoustic micro-imaging of the electrically stimulated rat brain with multiwavelengths

Lun-De Liao, Meng-Lin Li, Hsin-Yi Lai, You-Yin Chen, Paul C.-P. Chao, Po-Hsun Wang

Proceedings Volume 7564, 75643F (2010) https://doi.org/10.1117/12.843085

KEYWORDS: Brain, Neuroimaging, In vivo imaging, Tissue optics, Photoacoustic spectroscopy, Photoacoustic microscopy, Ultrasonography, Biomedical optics, Signal detection, Somatosensory cortex

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Proceedings Article | 18 September 2006 Paper

A novel display metrology method for LED backlight system

Jee-Gong Chang, Lun-De Liao, Chi-Chuan Hwang

Proceedings Volume 6338, 63380I (2006) https://doi.org/10.1117/12.678031

KEYWORDS: Luminous efficiency, Statistical analysis, Waveguides, Statistical modeling, LCDs, Systems modeling, Light emitting diodes, LED backlight, Manufacturing, Diffusers

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Proceedings Article | 18 September 2006 Paper

The analysis of light extraction efficiency of GaN-based LEDs with a novel micro-cavity

Jee-Gong Chang, Lun-De Liao, Chi-Chuan Hwang

Proceedings Volume 6337, 63371I (2006) https://doi.org/10.1117/12.678662

KEYWORDS: Light emitting diodes, Monte Carlo methods, Gallium nitride, Light, Absorption, Sapphire, Ray tracing, Scattering, Light scattering, LCDs

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Proceedings Article | 5 September 2006 Paper

Enhancement of the optical performances for the LED backlight systems with a novel lens cap

Jee-Gong Chang, Charles Lun-De Liao, Chi-Chuan Hwang

Proceedings Volume 6289, 62890X (2006) https://doi.org/10.1117/12.678040

KEYWORDS: Light emitting diodes, LED backlight, Lens design, Diffusers, Light sources, Reflectivity, Integrating spheres, RGB color model, Metals, Geometrical optics

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Proceedings Article | 21 April 2006 Paper

Design of a novel LED lens cap and optimization of LED placement in a large-area direct backlight for LCD-TVs

Paul C.-P. Chao, Lun-De Liao, Chi-Wei Chiu

Proceedings Volume 6196, 61960N (2006) https://doi.org/10.1117/12.661894

KEYWORDS: Light emitting diodes, Reflectivity, LED backlight, Lens design, Light sources, Optimization (mathematics), Diffusers, Geometrical optics, LCDs, RGB color model

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A novel cone-shaped lens cap for High Brightness Light Emitting Diodes (HB-LEDs) is proposed for improving brightness and high uniformity of the direct LED Backlight Units (BLUs) for large area LCD-TVs. Combining the designed lens cap with red, green and blue (RGB) chips on a Metal Core Printed Circuit Board (MCPCB), the LED module with the proposed cap is able to provide a compact white light source with unique features such as instant color variability and lower power usage, etc [1] [2]. The cone shape of the proposed lens cap is designed to emit only a small portion of light upward along the optical axis of the lens, while most of the light rays to the sides, providing a uniform luminance distribution and the high brightness on the backlight. In addition, a small, local square reflective box is designed and coupled to enclose the proposed LED module[3] [4] [5], the inner surfaces of which are attached with reflective films to increase the level of light mixing in the larger, global reflector box. With the structure of the LED module well designed, the placement of the LED modules in the BLU is next optimized via the method of optimization algorithm (OA). In the process of OA executions, the locations of the LED modules are the design factors to be optimized with chosen enclosure dimensions and number of LEDs to maximize brightness and uniformity of the entire BLU. Moreover, in the OA process, the software TRACEPRO is utilized to compute brightness and uniformity of the BLU with certain combination of the aforementioned design and control parameters considered. With the theoretically-optimized placement of the LED modules in hand, experiments based on a realistic BLU built in the laboratory are conducted to verify the performance of the proposed LED module and associated optimized locations. The results indeed identify the attributes of the BLU, which make it possible to achieve excellent backlight performance using a direct illumination approach from the light source of "Cone-Shaped Lens Cap of LEDs".

Showing 5 of 14 publications

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