Dr. Pramanik received his Ph.D. degree (2010) in Biomedical Engineering from Washington University in St. Louis, Missouri, USA. He joined Department of Electrical and Computer Engineering at Iowa State University from spring 2023 as Associate Professor. He is also a Faculty of Biomedical Engineering at Iowa State University. Prior to that, he was at Nanyang Technological University (NTU), Singapore from 2014-2022. He obtained his masters (MTech) from Department of Instrumentation at Indian Institute of Science (IISc), Bangalore, India in 2004 and his undergraduate (BTech) from the Department of Electrical Engineering at Indian Institute of Technology (IIT), Kharagpur, India in 2002. He also served as Assistant Professor in the Department of Electrical Engineering at Indian Institute of Science (IISc), Bangalore, India 2012-2013. His industry experiences include two years at General Electric Global Research (GRC), Bangalore, India and one year at Philips Medical System, Bangalore, India. His research interest is in Medical Imaging Systems, Photoacoustic and Thermoacoustic Imaging, Image Reconstruction, Machine Learning, Contrast Agents, Molecular Imaging, Monte-Carlo Simulation for light-tissue interaction. He has more than 250 international journal and conference publications and presentations. Professor Pramanik has received research grants as principal investigator, with a cumulative budget of over $3.5M. He serves as an Associate Editor of the Journal of Biomedical Optics, and as an Editorial Board Member of Photoacoustics. He also served as Guest Editor for special issues in the Journal of Biomedical Optics, Biomedical Engineering Letters. He is a Senior Member of SPIE, IEEE. Professor Pramanik is also the inaugural “Biodesign Faculty Fellow” offered by the Singapore Biodesign Programme (in collaboration with Stanford Biodesign Fellowship).
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Photoacoustic imaging (PAI) provides high-resolution and high-optical-contrast imaging beyond optical diffusion limit. Further improvement in imaging depth has been achieved by using near-infrared window-I (NIR-I, 700 to 900 nm) for illumination, due to lower scattering and absorption by tissues in this wavelength range. Recently, near-infrared window-II (NIR-II, 900 to 1700 nm) has been explored for PAI. We studied the imaging depths in biological tissues for different illumination wavelengths in visible, NIR-I, and NIR-II regions using Monte Carlo (MC) simulations and validated with experimental results. MC simulations were done to compute fluence in tissue, absorbance in blood vessel, and in a spherical absorber (mimicking sentinel lymph node) embedded at different depths in breast tissue. Photoacoustic tomography and acoustic resolution photoacoustic microscopy experiments were conducted to validate the MC results. We demonstrate that maximum imaging depth is achieved by wavelengths in NIR-I window (∼800 nm) when the energy density deposited is same for all wavelengths. However, illumination using wavelengths around 1064 nm (NIR-II window) gives the maximum imaging depth when the energy density deposited is proportional to maximum permissible exposure (MPE) at corresponding wavelength. These results show that it is the higher MPE of NIR-II window that helps in increasing the PAI depth for chromophores embedded in breast tissue.
Blockage of healthy blood vessels by blood clots can lead to serious or even life-threatening complications. The use of a combined ultrasound (US) and photoacoustic (PA) imaging was explored for blood clot monitoring during microbubble-assisted sonothrombolysis. PA imaging is an emerging hybrid imaging modality that has garnered the attention of the biomedical imaging community in recent years. It enables the study of the composition of a blood clot due to its sensitivity toward optical absorption. Here,
A robust modified delay-and-sum algorithm for photoacoustic tomography imaging with apodized sensors
Photoacoustic cystography using handheld dual modal clinical ultrasound photoacoustic imaging system
Microfluidics-based microbubbles in methylene blue solution for photoacoustic and ultrasound imaging
White light single-shot interferometry with colour CCD camera for optical inspection of microsystems
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