Ms. Mei Takahashi Profile

Mei Takahashi

at Keio Univ

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Author

Publications (10)

Proceedings Article | 4 March 2014 Paper

Prediction of myocardial damage depth induced by extracellular photosensitization reaction using fluorescence measurement in vivo

M. Takahashi, E. Ogawa, T. Nakamura, H. Kawakami, N. Machida, M. Yajima, M. Kurotsu, A. Ito, T. Kimura, T. Arai

Proceedings Volume 8926, 89262X (2014) https://doi.org/10.1117/12.2036506

KEYWORDS: Luminescence, Backscatter, Heart, In vivo imaging, Sodium, Oxygen, Blood circulation, Laser irradiation, Francium, Ions

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Proceedings Article | 26 February 2014 Paper

Photosensitization reaction along depth of a culture well with high concentration of talaporfin sodium for extra-cellular photodynamic therapy study

Masahiro Yajima, Hiroshige Kawakami, Emiyu Ogawa, Mei Takahashi, Tsunenori Arai

Proceedings Volume 8941, 89410V (2014) https://doi.org/10.1117/12.2041950

KEYWORDS: Oxygen, Sodium, Electrodes, Photodynamic therapy, Temperature metrology, Laser irradiation, In vitro testing, Tissue optics, Tissues, Diffusion

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Proceedings Article | 26 February 2014 Paper

Comparison of human serum and bovine serum albumins on oxidation dynamics induced by talaporfin sodium photosensitization reaction with albumin rich conditions: solution experiments

Mariko Kurotsu, Tetsuya Nakamura, Mei Takahashi, Emiyu Ogawa, Tsunenori Arai

Proceedings Volume 8941, 89410F (2014) https://doi.org/10.1117/12.2039028

KEYWORDS: Sodium, Absorption, Absorbance, Photodynamic therapy, Semiconductor lasers, Cancer, Oncology, Blood, Plasma, Oxidation

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Proceedings Article | 26 February 2014 Paper

Immediate response of Ca2+ concentration in myocardial cells against oxidation stress by extracellular photosensitization reaction using Talaporfin sodium for the arrhythmia treatment application

Emiyu Ogawa, Mei Takahashi, Arisa Ito, Tsunenori Arai

Proceedings Volume 8941, 89410U (2014) https://doi.org/10.1117/12.2038586

KEYWORDS: Sodium, Luminescence, Laser irradiation, Microscopes, Confocal microscopy, Veins, Glasses, Absorbance, Semiconductor lasers, Oxidation

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Proceedings Article | 24 June 2013 Paper

Extracellular photosensitization reaction progress and effect on myocardial cell necrosis for arrhythmia treatment application

Emiyu Ogawa, Mei Takahashi, Arisa Ito, Tsunenori Arai

Proceedings Volume 8803, 88030K (2013) https://doi.org/10.1117/12.2035034

KEYWORDS: Oxygen, Laser irradiation, Absorbance, Sodium, Tissues, Luminescence, Photodynamic therapy, Biomedical optics, Laser ablation, In vitro testing

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Proceedings Article | 8 March 2013 Paper

Electrophysiological and histological effects on canine right atrium by photosensitization reaction under catheterization in vivo

M. Takahashi, E. Ogawa, S. Motohashi, T. Nakamura, H. Kawakami, N. Machida, A. Ito, T. Kimura, S. Takatsuki, K. Fukumoto, S. Miyoshi, K. Fukuda, T. Arai

Proceedings Volume 8565, 85654A (2013) https://doi.org/10.1117/12.2000619

KEYWORDS: Sodium, Plasma, Heart, Veins, Blood, Electrodes, Atrial fibrillation, Francium, In vivo imaging, Tissues

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Proceedings Article | 15 February 2013 Paper

Study of photosensitization reaction progress in a 96 well plate with photosensitizer rich condition using Talaporfin sodium.

Emiyu Ogawa, Mei Takahashi, Tsunenori Arai

Proceedings Volume 8579, 85790D (2013) https://doi.org/10.1117/12.2003288

KEYWORDS: Oxygen, Sodium, Laser irradiation, Luminescence, Absorbance, In vitro testing, Diffusion, Laser tissue interaction, Ions, Tissue optics

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To quantitatively investigate photosensitization reaction in vitro against myocardial cells with photosensitizer rich condition in solution using Talaporfin sodium in the well of a 96 well plate, we studied photosensitization reaction progress in this well. We have proposed non-thermal conduction block of myocardium tissue using the photosensitization reaction with laser irradiation shortly after Talaporfin sodium injection. In above situation, the photosensitizer is located outside the myocardial cells in high concentration. To understand interaction of the photosensitization reaction in which the photosensitizer distributes outside cells, the photosensitization reaction progress in the well was studied. Talaporfin sodium (799.69 MW) solution and a 663 nm diode laser were used. The photosensitizer solution concentrations of 12.5-37.5 μM were employed. The photosensitizer fluorescence with 0.29 W/cm² in irradiance, which was optimized in previous cell death study, was measured during the laser irradiation until 40 J/cm². The photosensitizer solution absorbance and dissolved oxygen pressure after the laser irradiation were also measured. We found that the photosensitization reaction progress had 2 distinctive phases of different reaction rate: rapid photosensitization reaction consuming dissolved oxygen and gentle photosensitization reaction with oxygen diffusion from the solution-air boundary. The dissolved oxygen pressure and photosensitizer solution absorbance were 30% and 80% of the initial values after the laser irradiation, respectively. Therefore, oxygen was rate-controlling factor of the photosensitization reaction in the well with the photosensitizer rich condition. In the oxygen diffusion phase, the oxygen pressure was maintained around 40 mmHg until the laser irradiation of 40 J/cm² and it is similar to that of myocardium tissue in vivo. We think that our 96 well plate in vitro system may simulate PDT in myocardial tissue with photosensitization reaction parameters mentioned above.

Proceedings Article | 9 February 2012 Paper

Optical property change of blood on an optical window boundary by 660-nm band laser irradiation

Mei Takahashi, Arisa Ito, Tsunenori Arai

Proceedings Volume 8221, 822116 (2012) https://doi.org/10.1117/12.905845

KEYWORDS: Blood, Laser irradiation, Integrating spheres, Optical properties, System integration, Collimation, Technetium, Optical testing, Laser scattering

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Proceedings Article | 18 February 2011 Paper

Non-thermal myocardial electrical conduction block by photosensitization reaction with catheterization in right atrium isthmus of porcine heart in vivo

Arisa Ito, Takuro Kajihara, Tsukasa Suenari, Mei Takahashi, Takehiro Kimura, Kotaro Fukumoto, Seiji Takatsuki, Shunichiro Miyoshi, Tsunenori Arai

Proceedings Volume 7883, 78833K (2011) https://doi.org/10.1117/12.872621

KEYWORDS: Electrodes, Heart, In vivo imaging, Laser ablation, Sodium, Tissue optics, Laser development, Oxygen, Diagnostics, Laser tissue interaction

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Proceedings Article | 18 February 2011 Paper

Detection of pre-charring optical behavior at a laser catheter-tip in blood: ex vivo and in vivo study

Mei Takahashi, Arisa Ito, Takuro Kajihara, Tsunenori Arai

Proceedings Volume 7897, 78970U (2011) https://doi.org/10.1117/12.874622

KEYWORDS: Blood, Laser irradiation, Beam controllers, In vivo imaging, Laser therapeutics, Optical testing, Backscatter, Laser tissue interaction, Microscopes, Absorption

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Showing 5 of 10 publications

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