Prof. Mikhail Y. Berezin Profile

Prof. Mikhail Y. Berezin

Associate Professor at Washington Univ. School of Medicine in St. Louis

SPIE Involvement:

Conference Chair | Editor | Author

Websites:

Personal Website

Publications (30)

Proceedings Article | 13 March 2024 Presentation

Optical window for visualization of peripheral nerves in animal models

Igor Luzhansky, Matt Wood, Mikhail Berezin

Proceedings Volume PC12862, PC1286206 (2024) https://doi.org/10.1117/12.3005750

KEYWORDS: Nerve, Animal model studies, Windows, Animals, Visualization, Visual process modeling, Process modeling, Muscles, In vivo imaging, Temporal resolution

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Proceedings Article | 13 March 2024 Poster + Paper

Investigating chemotherapy effects on peripheral nerve elasticity

Vsevolod Cheburkanov, Junwei Du, Mikhail Berezin, Vladislav Yakovlev

Proceedings Volume 12821, 1282109 (2024) https://doi.org/10.1117/12.3003568

KEYWORDS: Nerve, Chemotherapy, Elasticity, Cancer, Spectroscopy, Nervous system, Oncology, Materials properties, Biological samples, Biomedical optics

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SPIE Journal Paper | 26 August 2023 Open Access

Toward peripheral nerve mechanical characterization using Brillouin imaging spectroscopy

Vsevolod Cheburkanov, Junwei Du, David Brogan, Mikhail Berezin, Vladislav Yakovlev

NPh, Vol. 10, Issue 03, 035007, (August 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.3.035007

KEYWORDS: Nerve, Biological samples, Elasticity, Materials properties, Imaging spectroscopy, Nervous system, Spectroscopy, Injuries, Viscoelasticity, Neurons

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Proceedings Article | 17 March 2023 Presentation

Hyperspectral imaging in SWIR: Applications of geospatial approaches to biological imaging (Conference Presentation)

Hridoy Biswas, Helena Hurbon, Deependra Mishra, John Wang, Mikhail Berezin

Proceedings Volume PC12398, PC1239803 (2023) https://doi.org/10.1117/12.2654982

KEYWORDS: Short wave infrared radiation, Hyperspectral imaging, Tissues, Image processing, Tissue optics, Data processing, Chromophores, Algorithm development, Remote sensing, Pathophysiology

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Proceedings Article | 6 March 2023 Poster + Paper

Towards peripheral neuron regeneration: imaging nerve biomechanics using Brillouin spectroscopy

Vsevolod Cheburkanov, Junwei Du, Mikhail Berezin, Vladislav Yakovlev

Proceedings Volume 12373, 123730E (2023) https://doi.org/10.1117/12.2650957

KEYWORDS: Nerve, Spectroscopy, Neurons, Elasticity, Biomechanics, Nervous system, Imaging spectroscopy, Raman spectroscopy, Materials properties

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SPIE Journal Paper | 19 July 2022 Open Access

In vivo near-infrared fluorescent fibrin highlights growth of nerve during regeneration across a nerve gap

Igor Luzhansky, Emma Anisman, Dharma Patel, Naasik Syed, Matthew Wood, Mikhail Berezin

JBO, Vol. 27, Issue 07, 070502, (July 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.070502

KEYWORDS: Nerve, Tissues, In vivo imaging, Luminescence, Injuries, Nerve regeneration, Near infrared, Visualization, Magnetic resonance imaging, Axons

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Proceedings Article | 5 March 2021 Presentation

Noninvasive quantification of cutaneous inflammation with hyperspectral short wave infrared imaging

Leonid Shmuylovich, Deependra Mishra, Helena Hurbon, Tommy Du, Andy Yu, Steven Wang, Mikhail Berezin

Proceedings Volume 11618, 1161812 (2021) https://doi.org/10.1117/12.2584529

KEYWORDS: Skin, Inflammation, Infrared imaging, Visualization, Short wave infrared radiation, Tissues, Reflectivity, Absorption, Water, Visible radiation

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Proceedings Article | 4 March 2019 Presentation

Chemical synthesis of contrast probes on ultrasound confined particles (Conference Presentation)

Michael Binkley, Mikhail Berezin, J. Mark Meacham

Proceedings Volume 10893, 108930A (2019) https://doi.org/10.1117/12.2508876

KEYWORDS: Acoustics, Ultrasonography, Particles, Industrial chemicals, Glasses, Actinium, Polymers, Chemical reactions, Optical spheres, Proteins

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SPIE Journal Paper | 8 December 2016 Open Access

Penetration depth of photons in biological tissues from hyperspectral imaging in shortwave infrared in transmission and reflection geometries

Hairong Zhang, Daniel Salo, David Kim, Sergey Komarov, Yuan-Chuan Tai, Mikhail Berezin

JBO, Vol. 21, Issue 12, 126006, (December 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.12.126006

KEYWORDS: Tissues, Short wave infrared radiation, Photons, Absorption, Hyperspectral imaging, Scattering, Shortwaves, Infrared radiation, Infrared imaging, Spectral resolution

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Proceedings Article | 27 April 2016 Presentation

Hyperspectral imaging in SWIR: from stain-free microscopy to deep tissue imaging (Conference Presentation)

Mikhail Berezin

Proceedings Volume 9723, 97230M (2016) https://doi.org/10.1117/12.2216333

KEYWORDS: Short wave infrared radiation, Tissues, Hyperspectral imaging, Microscopy, Deep tissue imaging, Near infrared, Chromophores, Medicine, Infrared detectors, Infrared imaging

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Proceedings Article | 22 April 2016 Paper

Synthesis and spectroscopic evaluation of PbS quantum dots emitting at 1300 nm for optimized imaging in optical window II

Alexander Aydt, Shane Blair, Hairong Zhang, Boris Chernomordik, Matthew Beard, Mikhail Berezin

Proceedings Volume 9723, 97230Z (2016) https://doi.org/10.1117/12.2214509

KEYWORDS: Windows, Quantum dots, Tissue optics, Near infrared, Optical imaging, Quantum efficiency, Luminescence, Transparency, Imaging spectroscopy, Spectroscopy, Lead, Short wave infrared radiation, Imaging systems

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Proceedings Article | 7 March 2016 Presentation + Paper

Penetration depth in tissue-mimicking phantoms from hyperspectral imaging in SWIR in transmission and reflection geometry

Hairong Zhang, Daniel Salo, David Kim, Mikhail Berezin

Proceedings Volume 9703, 970311 (2016) https://doi.org/10.1117/12.2213754

KEYWORDS: Tissue optics, Short wave infrared radiation, Near infrared, Tissues, Hyperspectral imaging, Optical imaging, Deep tissue imaging, In vivo imaging, Visible radiation, Light scattering, Spectral resolution, Imaging systems, Sensors, Transparency, Indium gallium arsenide

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SPIE Journal Paper | 7 August 2014 Open Access

Multispectral measurement of contrast in tissue-mimicking phantoms in near-infrared spectral range of 650 to 1600 nm

Daniel Salo, Hairong Zhang, David Kim, Mikhail Berezin

JBO, Vol. 19, Issue 08, 086008, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086008

KEYWORDS: Tissue optics, Tissues, Photons, Sensors, Near infrared, Scattering, Absorption, Silicon, Indium gallium arsenide, Light scattering

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Proceedings Article | 17 March 2014 Paper

Wavelength-dependent measurement of contrast in NIR and extended NIR spectral range (650-1600 nm) in phantoms

Daniel Salo, David Kim, Mikhail Berezin

Proceedings Volume 8940, 89400O (2014) https://doi.org/10.1117/12.2044872

KEYWORDS: Near infrared, Indium gallium arsenide, Silicon, Tissue optics, Charge-coupled devices, Microscopes, Sensors, CCD image sensors, Visible radiation, MATLAB

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SPIE Journal Paper | 12 August 2013 Open Access

Multispectral imaging in the extended near-infrared window based on endogenous chromophores

Qian Cao, Natalia Zhegalova, Steven Wang, Walter Akers, Mikhail Berezin

JBO, Vol. 18, Issue 10, 101318, (August 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.10.101318

KEYWORDS: Tissues, Absorption, Proteins, Near infrared, Chromophores, Multispectral imaging, Indium gallium arsenide, Imaging systems, Absorbance, Water

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Proceedings Article | 22 March 2013 Paper

Bloodstain age analysis: toward solid state fluorescent lifetime measurements

Kevin Guo, Natalia Zhegalova, Samuel Achilefu, Mikhail Berezin

Proceedings Volume 8572, 857214 (2013) https://doi.org/10.1117/12.2007756

KEYWORDS: Blood, Luminescence, Solid state physics, Proteins, Urea, Forensic science, Solid state electronics, Environmental sensing, Microscopy, Urea concentration

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Proceedings Article | 22 February 2013 Paper

Multi-spectral analysis of animal tissues in the second NIR window based on endogenous chromophores

Qian Cao, Steven Wang, Natalia Zhegalova, Walter Akers, Mikhail Berezin

Proceedings Volume 8587, 85870V (2013) https://doi.org/10.1117/12.2008786

KEYWORDS: Tissues, Near infrared, Chromophores, Absorption, Indium gallium arsenide, Scattering, Imaging systems, Optical properties, Spectrophotometry, Tissue optics

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Proceedings Article | 21 February 2013 Paper

Molecular thermometers for potential applications in thermal ablation procedures

Natalia Zhegalova, Alex Aydt, Steven Wang, Mikhail Berezin

Proceedings Volume 8596, 85960I (2013) https://doi.org/10.1117/12.2008784

KEYWORDS: Rhodamine, Luminescence, Temperature metrology, Tumors, Absorption, Laser ablation, Sensors, In vivo imaging, Tissues, Energy transfer

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Proceedings Article | 2 February 2012 Paper

Time-domain imaging with quench-based fluorescent contrast agents

Walter Akers, Metasebya Solomon, Gail Sudlow, Mikhail Berezin, Samuel Achilefu

Proceedings Volume 8233, 82330G (2012) https://doi.org/10.1117/12.915917

KEYWORDS: Luminescence, Tumors, Fluorescence resonance energy transfer, In vivo imaging, Molecules, Quenching (fluorescence), Quantum efficiency, Tissues, Cancer, Near infrared

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Quench-based probes utilize unique characteristics of fluorescence resonance energy transfer (FRET) to enhance contrast upon de-quenching. This mechanism has been used in a variety of molecular probes for imaging of cancer related enzyme activity such as matrix metalloproteinases, cathepsins and caspases. While non-fluorescent upon administration, fluorescence can be restored by separation of donor and acceptor, resulting in higher intensity in the presence of activator. Along with decreased quantum yield, FRET also results in altered fluorescence lifetime. Time-domain imaging can further enhance contrast and information yield from quench-based probes. We present in vivo time-domain imaging for detecting activation of quench-based probes. Quench-based probes utilize unique characteristics of fluorescence resonance energy transfer (FRET) to enhance contrast upon de-quenching. This mechanism has been used in a variety of molecular probes for imaging of cancer related enzyme activity such as matrix metalloproteinases, cathepsins and caspases. While non-fluorescent upon administration, fluorescence can be restored by separation of donor and acceptor, resulting in higher intensity in the presence of activator. Along with decreased quantum yield, FRET also results in altered fluorescence lifetime. Time-domain imaging can further enhance contrast and information yield from quench-based probes. We present in vivo time-domain imaging for detecting activation of quench-based probes. Time-domain diffuse optical imaging was performed to assess the FRET and quenching in living mice with orthotopic breast cancer. Tumor contrast enhancement was accompanied by increased fluorescence lifetime after administration of quenched probes selective for matrix metalloproteinases while no significant change was observed for non-quenched probes for integrin receptors. These results demonstrate the utility of timedomain imaging for detection of cancer-related enzyme activity in vivo.

SPIE Journal Paper | 1 June 2011 Open Access

Detection of enzyme activity in orthotopic murine breast cancer by fluorescence lifetime imaging using a fluorescence resonance energy transfer-based molecular probe

Metasebya Solomon, Kevin Guo, Gail Sudlow, Mikhail Berezin, W. Barry Edwards, Samuel Achilefu, Walter Akers

JBO, Vol. 16, Issue 06, 066019, (June 2011) https://doi.org/10.1117/12.10.1117/1.3594153

KEYWORDS: Luminescence, Tumors, Fluorescence resonance energy transfer, Tissues, Breast cancer, In vivo imaging, Molecular energy transfer, Fluorescence lifetime imaging, Cancer, Near infrared

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Proceedings Article | 12 February 2011 Paper

Novel design of multimodal MRI/NIR optical contrast agent

Kevin Guo, Franck Lin, Walter Akers, Jie Zheng, Bao Teng, Olga Vasalatiy, Gary Griffiths, Amir Gandjbakhche, Mikhail Berezin, Samuel Achilefu

Proceedings Volume 7910, 791015 (2011) https://doi.org/10.1117/12.881395

KEYWORDS: Magnetic resonance imaging, Luminescence, Gadolinium, Diffusion, Metals, In vitro testing, Tissue optics, Near infrared, Optical imaging, Absorption

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Proceedings Article | 12 February 2011 Paper

Compact intraoperative imaging device for sentinel lymph node mapping

Yang Liu, Adam Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph Culver, Samuel Achilefu

Proceedings Volume 7910, 79100D (2011) https://doi.org/10.1117/12.886226

KEYWORDS: Lymphatic system, Near infrared, Luminescence, Imaging devices, Surgery, Cancer, Sensors, Light sources, Imaging systems, Tissues

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SPIE Journal Paper | 1 May 2010 Open Access

Multiphoton microscopy with near infrared contrast agents

Siavash Yazdanfar, Chulmin Joo, Chun Zhan, Mikhail Berezin, Walter Akers, Samuel Achilefu

JBO, Vol. 15, Issue 03, 030505, (May 2010) https://doi.org/10.1117/12.10.1117/1.3420209

KEYWORDS: Near infrared, Luminescence, Fiber lasers, Multiphoton microscopy, Absorption, Mirrors, Tissues, Microscopy, Visible radiation, Molecular imaging

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Proceedings Article | 18 March 2010 Paper

Multimodal nonlinear microscopy at 1.5 µm

Chun Zhan, Chulmin Joo, Qing Li, Mikhail Berezin, Walter Akers, Yunpeng Ye, Samuel Achilefu, Siavash Yazdanfar

Proceedings Volume 7569, 75691Z (2010) https://doi.org/10.1117/12.842573

KEYWORDS: Microscopy, Luminescence, Multiphoton microscopy, Near infrared, Tissues, Imaging systems, Visible radiation, Objectives, Multiphoton fluorescence microscopy, Fiber lasers

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Proceedings Article | 17 February 2010 Paper

Strategies for developing pH sensitive fluorescent probes

Mikhail Berezin, Kevin Guo, Hyeran Lee, Walter Akers, Adah Almutairi, Jean M. Fréchet, Samuel Achilefu

Proceedings Volume 7576, 75760F (2010) https://doi.org/10.1117/12.849452

KEYWORDS: Nanoparticles, Luminescence, Near infrared, In vivo imaging, Absorption, Environmental sensing, Pathology, Dendrimers, Sensors, Blood

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Proceedings Article | 17 February 2010 Paper

Biological applications of fluorescence lifetime imaging beyond microscopy

Walter Akers, Mikhail Berezin, Hyeran Lee, Kevin Guo, Adah Almutairi, Jean M. Fréchet, Georg Fischer, Ewald Daltrozzo, Samuel Achilefu

Proceedings Volume 7576, 757612 (2010) https://doi.org/10.1117/12.849453

KEYWORDS: Luminescence, In vivo imaging, Tissues, Near infrared, Imaging systems, Fluorescence lifetime imaging, Diffuse optical imaging, Proteins, Microscopy, Cancer

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SPIE Journal Paper | 1 March 2009 Open Access

Dynamic noninvasive monitoring of renal function in vivo by fluorescence lifetime imaging

Reece Goiffon, Walter Akers, Mikhail Berezin, Hyeran Lee, Samuel Achilefu

JBO, Vol. 14, Issue 02, 020501, (March 2009) https://doi.org/10.1117/12.10.1117/1.3095800

KEYWORDS: Bladder, Luminescence, Proteins, Fluorescence lifetime imaging, Kidney, In vivo imaging, Molecules, Tissues, Near infrared, Medicine

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Proceedings Article | 21 February 2009 Paper

In vivo imaging with near-infrared fluorescence lifetime contrast

Walter Akers, Mikhail Berezin, Hyeran Lee, Samuel Achilefu

Proceedings Volume 7190, 71900T (2009) https://doi.org/10.1117/12.809621

KEYWORDS: Luminescence, Tissues, Near infrared, Liver, In vivo imaging, Nanoparticles, Absorption, Environmental sensing, Bladder, Fluorescence lifetime imaging

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SPIE Journal Paper | 1 September 2008 Open Access

Predicting in vivo fluorescence lifetime behavior of near-infrared fluorescent contrast agents using in vitro measurements

Walter Akers, Mikhail Berezin, Hyeran Lee, Samuel Achilefu

JBO, Vol. 13, Issue 05, 054042, (September 2008) https://doi.org/10.1117/12.10.1117/1.2982535

KEYWORDS: In vivo imaging, Luminescence, Near infrared, In vitro testing, Liver, Tissues, Bladder, Proteins, Kidney, Molecules

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Proceedings Article | 22 February 2008 Paper

Fluorescent lifetime of near infrared dyes for structural analysis of serum albumin

Mikhail Berezin, Hyeran Lee, Walter Akers, Gregory Nikiforovich, Samuel Achilefu

Proceedings Volume 6867, 68670J (2008) https://doi.org/10.1117/12.769262

KEYWORDS: Luminescence, Near infrared, Proteins, Polarizability, Blood, Urea, Absorption, Bioalcohols, Structural analysis, Molecules

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Showing 5 of 30 publications

Proceedings Volume Editor (3)

SPIE Conference Volume | 29 March 2024

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV

SPIE Conference Volume | 2 May 2023

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV

SPIE Conference Volume | 14 April 2022

Frontiers in Biological Detection: From Nanosensors to Systems XIV

Conference Committee Involvement (17)

Reporters, Contrast Agents, and Molecular Probes for Biomedical Applications XVI

28 January 2025 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV

30 January 2024 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIV

31 January 2023 | San Francisco, California, United States

Frontiers in Biological Detection: From Nanosensors to Systems XIV

23 January 2022 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII

6 March 2021 | Online Only, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII

4 February 2020 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI

4 February 2019 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X

29 January 2018 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX

30 January 2017 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VIII

15 February 2016 | San Francisco, California, United States

Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VII

9 February 2015 | San Francisco, California, United States