We have developed a new µOCT tethered Capsule Endomicroscopy imaging system for the diagnosis of Inflammatory bowel disease and Gastrointestinal cancer with micrometer resolution. The capsule we built measures 30 mm in length and 11 mm in diameter. By employing an optical design that incorporates the mirror tunnel design, we achieved a lateral resolution of less than 4 µm across a depth of field of 450 µm. The spectrometer we designed provides a resolution of 1.8 µm over a 4 mm imaging range, with an A-scan rate of up to 300 kHz. Imaging performance is demonstrated by beam profiling and imaging esophagus ex vivo.
Micro-optical coherence tomography (µOCT), is an emerging optical imaging approach enabling visualization of tissue microstructures at near cellular level. Small form-factor fiber-optic probes are needed to enable uOCT devices for minimally invasive diagnostic procedures such as coronary catheterization for atherosclerosis evaluation. Manufacturing complexities associated with miniaturizing current fiber-optic probes limit their optical and mechanical performance. We will present details of the design and construction of these miniaturized µOCT probes comprising TPL-based 3D printed optics, along with pre-clinical imaging results from an animal model. This probe is capable of lateral resolution of 5 µm and EDOF exceeding 850 µm in tissue.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.