The Oxford nomenclature was developed to distinguish the type of cataract based on the optical signal discontinuity (OSD) zones. The OSD zones were used to distinguish sections within the crystalline lens in our study using OCT images. A swept-source OCT was used to observe in-vivo age-related changes in the crystalline lens from the 50 healthy eyes with the age range of 9 to 78 years. The C3 layer (from oxford nomenclature) of the cortex was identified as the section of the crystalline that contributes highly to the age-related changes. We compared age-related degradation of the optical quality of the crystalline lens measurements using commercial VAO and OQAS systems with a custom-built SS-OCT system.
Swept source OCT was used to image crystalline lens of 100 eyes (age range: 9-78 years) and 3-dimensional lens suture structure was visualized in vivo for the first time. Lens suture patterns were extracted using average intensity projections (AIP) or cortical layers of crystalline lens. Our imaging system has capacity to extract complex star-sutures from cortical layers of lens and simple Y-sutures from fetal nucleus of crystalline lens. Age-related changes in lens and lens sutures were observed and were characterized quantitatively. The developed imaging system can be used to study growth of crystalline lens and its age-related diseases like cataract, presbyopia.
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