Dr. R. Daniel Ferguson Profile

Dr. R. Daniel Ferguson

Principal Research Scientist at Physical Sciences Inc

SPIE Involvement:

Author

Publications (35)

Proceedings Article | 5 March 2021 Presentation + Paper

Simultaneous multi-offset imaging of retinal microstructures free of directionality artifacts

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230E (2021) https://doi.org/10.1117/12.2583298

KEYWORDS: Retinal scanning, Optical fibers, Imaging systems, Scanning laser ophthalmoscopy, Scanning laser ophthalmoscopes, Light scattering, Detector development, Capillaries, Blood vessels, Blood

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Proceedings Article | 5 March 2021 Presentation + Paper

Choroidal and retinal hemodynamic imager

Mircea Mujat, Ankit Patel, Gopi Maguluri, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 11623, 116230G (2021) https://doi.org/10.1117/12.2583310

KEYWORDS: Optical coherence tomography, Hemodynamics, Imaging systems, Blood circulation, Visualization, Doppler tomography, Veins, Sensors, Retina, Ophthalmic imaging

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Proceedings Article | 26 April 2016 Presentation

OCT-based profiler for automating ocular surface prosthetic fitting (Conference Presentation)

Mircea Mujat, Ankit Patel, Gopi Maguluri, Nicusor Iftimia, Chirag Patel, Josh Agranat, Olga Tomashevskaya, Eugene Bonte, R. Daniel Ferguson

Proceedings Volume 9693, 96930Z (2016) https://doi.org/10.1117/12.2213938

KEYWORDS: Optical coherence tomography, Sclera, Cornea, Eye, 3D metrology, Physical sciences, Contact lenses, Holmium, Current controlled current source

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Proceedings Article | 11 March 2015 Paper

High-resolution retinal imaging: enhancement techniques

Mircea Mujat, Ankit Patel, Nicusor Iftimia, James Akula, Anne Fulton, R. Daniel Ferguson

Proceedings Volume 9307, 930703 (2015) https://doi.org/10.1117/12.2082711

KEYWORDS: Image registration, Imaging systems, Linear filtering, Sensors, Retinal scanning, Digital imaging, Detection and tracking algorithms, Channel projecting optics, Convolution, Matrices

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Proceedings Article | 3 March 2014 Paper

Compact adaptive optics line scanning retinal imager; closer to the clinic

Mircea Mujat, Ankit Patel, Nicusor Iftimia, R. Daniel Ferguson

Proceedings Volume 8930, 89301B (2014) https://doi.org/10.1117/12.2040261

KEYWORDS: Adaptive optics, Imaging systems, Optical coherence tomography, Confocal microscopy, Scanning laser ophthalmoscopy, Cones, Image resolution, Eye, Head, Retinal scanning

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Proceedings Article | 27 September 2013 Paper

Mueller matrix microscopy

Mircea Mujat, R. Daniel Ferguson, Nicusor Iftimia

Proceedings Volume 8873, 88730E (2013) https://doi.org/10.1117/12.2024962

KEYWORDS: Polarization, Microscopes, Optical components, Wave plates, Polarizers, Polarimetry, Microscopy, Refractive index, Birefringence, Dichroic materials

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SPIE Journal Paper | 13 March 2012 Open Access

Angiography with a multifunctional line scanning ophthalmoscope

Daniel Hammer, R. Daniel Ferguson, Ankit Patel, Vanessa Vazquez, Deeba Husain

JBO, Vol. 17, Issue 02, 026008, (March 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.026008

KEYWORDS: Angiography, Imaging systems, Confocal microscopy, Photodynamic therapy, Eye, Sensors, Video, Reflectivity, Optical filters, Image resolution

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Proceedings Article | 16 February 2011 Paper

Towards real-time wavefront sensorless adaptive optics using a graphical processing unit (GPU) in a line scanning system

David Biss, Ankit Patel, R. Daniel Ferguson, Mircea Mujat, Nicusor Iftimia, Daniel Hammer

Proceedings Volume 7885, 788516 (2011) https://doi.org/10.1117/12.876645

KEYWORDS: Adaptive optics, Sensors, Mirrors, Wavefronts, Imaging systems, Image sensors, Wavefront sensors, Eye, Graphics processing units, Eye models

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Proceedings Article | 16 February 2011 Paper

Advanced capabilities of the multimodal adaptive optics imager

Daniel Hammer, R. Ferguson, Mircea Mujat, David Biss, Nicusor Iftimia, Ankit Patel, Emily Plumb, Melanie Campbell, Jennifer Norris, Alfredo Dubra, Toco Chui, James Akula, Anne Fulton

Proceedings Volume 7885, 78850A (2011) https://doi.org/10.1117/12.876579

KEYWORDS: Optical coherence tomography, Scanning laser ophthalmoscopy, Adaptive optics, Imaging systems, Raster graphics, Video, Multichannel imaging systems, Image registration, Scanners, Doppler effect

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Proceedings Article | 3 March 2010 Paper

Multimodal adaptive optics for depth-enhanced high-resolution ophthalmic imaging

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, Niyom Lue, R. Daniel Ferguson

Proceedings Volume 7550, 755011 (2010) https://doi.org/10.1117/12.846583

KEYWORDS: Adaptive optics, Optical coherence tomography, Scanning laser ophthalmoscopy, Imaging systems, Eye, Eye models, Point spread functions, Retina, Human subjects, Algorithm development

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We developed a multimodal adaptive optics (AO) retinal imager for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular degeneration (AMD), and retinitis pigmentosa (RP). The development represents the first ever high performance AO system constructed that combines AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. The SSOCT channel operates at a wavelength of 1 μm for increased penetration and visualization of the choriocapillaris and choroid, sites of major disease activity for DR and wet AMD. The system is designed to operate on a broad clinical population with a dual deformable mirror (DM) configuration that allows simultaneous low- and high-order aberration correction. The system also includes a wide field line scanning ophthalmoscope (LSO) for initial screening, target identification, and global orientation; an integrated retinal tracker (RT) to stabilize the SLO, OCT, and LSO imaging fields in the presence of rotational eye motion; and a high-resolution LCD-based fixation target for presentation to the subject of stimuli and other visual cues. The system was tested in a limited number of human subjects without retinal disease for performance optimization and validation. The system was able to resolve and quantify cone photoreceptors across the macula to within ~0.5 deg (~100-150 μm) of the fovea, image and delineate ten retinal layers, and penetrate to resolve targets deep into the choroid. In addition to instrument hardware development, analysis algorithms were developed for efficient information extraction from clinical imaging sessions, with functionality including automated image registration, photoreceptor counting, strip and montage stitching, and segmentation. The system provides clinicians and researchers with high-resolution, high performance adaptive optics imaging to help guide therapies, develop new drugs, and improve patient outcomes.

SPIE Journal Paper | 1 May 2009 Open Access

Automated algorithm for breast tissue differentiation in optical coherence tomography

Mircea Mujat, Robert Ferguson, Daniel Hammer, Christopher Gittins, Nicusor Iftimia

JBO, Vol. 14, Issue 03, 034040, (May 2009) https://doi.org/10.1117/12.10.1117/1.3156821

KEYWORDS: Tissues, Optical coherence tomography, Tissue optics, Tumors, Biopsy, Breast, Reflectivity, Diagnostics, Coherence imaging, Image processing

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Proceedings Article | 20 February 2009 Paper

Swept-source parallel OCT

Mircea Mujat, Nicusor Iftimia, R. Daniel Ferguson, Daniel Hammer

Proceedings Volume 7168, 71681E (2009) https://doi.org/10.1117/12.809915

KEYWORDS: Optical coherence tomography, Sensors, Image processing, Mirrors, Tissues, Charge-coupled devices, Cameras, Reflectivity, Spectroscopy, Data acquisition

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Proceedings Article | 18 February 2009 Paper

Multimodal scanning laser ophthalmoscopy for image guided treatment of age-related macular degeneration

Daniel Hammer, R. Ferguson, Ankit Patel, Nicusor Iftimia, Mircea Mujat, Deeba Husain

Proceedings Volume 7163, 71631C (2009) https://doi.org/10.1117/12.810050

KEYWORDS: Photodynamic therapy, Angiography, Imaging systems, Eye, Electronics, Confocal microscopy, Scanning laser ophthalmoscopy, Sensors, Head, Video

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Proceedings Article | 18 February 2009 Paper

Compact adaptive optics line scanning laser ophthalmoscope

Daniel Hammer, Mircea Mujat, Nicusor Iftimia, R. Ferguson

Proceedings Volume 7163, 71630J (2009) https://doi.org/10.1117/12.810445

KEYWORDS: Adaptive optics, Cones, Imaging systems, Sensors, Wavefronts, Mirrors, Eye, Retina, Scanning laser ophthalmoscopes, Capillaries

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Proceedings Article | 5 March 2007 Paper

High resolution retinal imaging with a compact adaptive optics spectral domain optical coherence tomography system

Daniel Hammer, Nicusor Iftimia, Chad Bigelow, Teoman Ustun, Benjamin Bloom, R. Daniel Ferguson, Stephen Burns

Proceedings Volume 6426, 64261Q (2007) https://doi.org/10.1117/12.703164

KEYWORDS: Adaptive optics, Optical coherence tomography, Scanning laser ophthalmoscopy, Image resolution, Imaging systems, Wavefronts, Eye, Spectral resolution, Raster graphics, Retinal scanning

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Proceedings Article | 10 February 2007 Paper

Three-dimensional tracker for spectral domain optical coherence tomography

Daniel Hammer, Nicusor Iftimia, Chad Bigelow, Teoman Ustun, Benjamin Bloom, R. Daniel Ferguson, Thomas Milner

Proceedings Volume 6429, 642913 (2007) https://doi.org/10.1117/12.704663

KEYWORDS: Optical coherence tomography, Image processing, Imaging systems, Autoregressive models, 3D image processing, Eye, Sensors, Tissues, Optical tracking, Interferometers

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Proceedings Article | 9 February 2007 Paper

Hybrid LSLO/SDOCT retinal imager

Nicusor Iftimia, Daniel Hammer, Chad Bigelow, Teoman Ustun, Andrew Burbo, Johannes de Boer, R. Daniel Ferguson

Proceedings Volume 6426, 642602 (2007) https://doi.org/10.1117/12.701713

KEYWORDS: Optical coherence tomography, Imaging systems, Sensors, Cameras, Data acquisition, Scanners, Light sources, Eye, Raster graphics, Control systems

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Proceedings Article | 9 February 2007 Paper

Ultrahigh-resolution adaptive optics - optical coherence tomography: toward isotropic 3-um resolution for in vivo retinal imaging

Robert Zawadzki, Yan Zhang, Steven Jones, R. Daniel Ferguson, Stacey Choi, Barry Cense, Julia Evans, Diana Chen, Donald Miller, Scot Olivier, John Werner

Proceedings Volume 6429, 642909 (2007) https://doi.org/10.1117/12.704639

KEYWORDS: Adaptive optics, Adaptive optics optical coherence tomography, Optical coherence tomography, Eye, Light sources, Wavefronts, Image resolution, Chromatic aberrations, Retina, Imaging systems

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SPIE Journal Paper | 1 July 2006 Open Access

Line-scanning laser ophthalmoscope

Daniel Hammer, R. Daniel Ferguson, Teoman Ustun, Chad Bigelow, Nicusor Iftimia, Robert Webb

JBO, Vol. 11, Issue 04, 041126, (July 2006) https://doi.org/10.1117/12.10.1117/1.2335470

KEYWORDS: Scanning laser ophthalmoscopy, Confocal microscopy, Sensors, Cameras, Retina, Eye, Electronics, Point spread functions, Optical components, Glasses

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Proceedings Article | 7 March 2006 Paper

Tracking adaptive optics scanning laser ophthalmoscope

R. Daniel Ferguson, Daniel Hammer, Chad Bigelow, Nicusor Iftimia, Teoman Ustun, Stephen Burns, Ann Elsner, David Williams

Proceedings Volume 6138, 613810 (2006) https://doi.org/10.1117/12.649332

KEYWORDS: Adaptive optics, Eye, Mirrors, Scanning laser ophthalmoscopy, Imaging systems, Cones, Optical tracking, Raster graphics, Scanning laser ophthalmoscopes, Digital signal processing

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Proceedings Article | 7 March 2006 Paper

Precision targeting with a tracking adaptive optics scanning laser ophthalmoscope

Daniel Hammer, R. Daniel Ferguson, Chad Bigelow, Nicusor Iftimia, Teoman Ustun, Gary Noojin, David Stolarski, Harvey Hodnett, Michelle Imholte, Semih Kumru, Michelle McCall, Cynthia Toth, Benjamin Rockwell

Proceedings Volume 6138, 613811 (2006) https://doi.org/10.1117/12.647477

KEYWORDS: Adaptive optics, Scanning laser ophthalmoscopy, Eye, Imaging systems, Mirrors, Retina, Cameras, Cones, Deformable mirrors, Raster graphics

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Proceedings Article | 25 February 2006 Paper

Noninvasive monitoring of blood composition

Nicusor Iftimia, Daniel Hammer, David Rosen, Chad Bigelow, R. Daniel Ferguson

Proceedings Volume 6080, 608002 (2006) https://doi.org/10.1117/12.647045

KEYWORDS: Blood, Reflectivity, Eye, Scattering, Interferometers, Interferometry, Signal processing, Spectroscopy, Motion measurement, Light sources

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Proceedings Article | 18 April 2005 Paper

Dual OCT-SLO imager with 3D tracker

Daniel Hammer, Teoman Ustun, Nick Iftimia, John Magill, R. Daniel Ferguson

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.592762

KEYWORDS: Optical coherence tomography, Signal detection, Scanning laser ophthalmoscopy, Imaging systems, Optical tracking, Signal processing, Bragg cells, Confocal microscopy, 3D image processing, Image resolution

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Proceedings Article | 13 April 2005 Paper

Three-dimensional retinal maps with tracking optical coherence tomography (TOCT)

R. Daniel Ferguson, Daniel Hammer, Nicusor Iftimia, Karim Slaoui, Gadi Wollstein, Hiroshi Ishikawa, Michelle Gabriele, Joel Schuman

Proceedings Volume 5690, (2005) https://doi.org/10.1117/12.591764

KEYWORDS: Optical coherence tomography, Optical tracking, Eye, Composites, Mirrors, Imaging systems, Head, 3D acquisition, Signal processing, Image registration

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SPIE Journal Paper | 1 March 2005 Open Access

Active retinal tracker for clinical optical coherence tomography systems

Daniel Hammer, R. Daniel Ferguson, John Magill, Lelia Paunescu, Siobahn Beaton, Hiroshi Ishikawa, Gadi Wollstein, Joel Schuman

JBO, Vol. 10, Issue 02, 024038, (March 2005) https://doi.org/10.1117/12.10.1117/1.1896967

KEYWORDS: Optical coherence tomography, Eye, Detection and tracking algorithms, Retina, Optical tracking, Error analysis, Image registration, Mirrors, Signal to noise ratio, Speckle

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Proceedings Article | 13 July 2004 Paper

Wide-field stabilized Doppler flowmetry with the tracking scanning laser ophthalmoscope (TSLO)

R. Ferguson, Daniel Hammer, Ann Elsner, Stephen Burns, Robert Webb, John Weiter

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.532186

KEYWORDS: Doppler effect, Eye, Blood circulation, Retina, Diagnostics, Scanning laser ophthalmoscopy, Doppler tomography, Scanning laser ophthalmoscopes, Visualization, Angiography

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Proceedings Article | 13 July 2004 Paper

Hand-held digital line-scanning laser ophthalmoscope (LSLO)

Daniel Hammer, R. Ferguson, Teoman Ustun, Gami Maislin, Robert Webb

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.532066

KEYWORDS: Scanning laser ophthalmoscopy, Cameras, Sensors, Confocal microscopy, Retina, Image segmentation, Field programmable gate arrays, Signal processing, Imaging arrays, Liquid crystals

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Proceedings Article | 14 July 2003 Paper

Tracking scanning laser ophthalmoscope (TSLO)

Daniel Hammer, R. Daniel Ferguson, John Magill, Michael White, Ann Elsner, Robert Webb

Proceedings Volume 4951, (2003) https://doi.org/10.1117/12.477974

KEYWORDS: Eye, Scanning laser ophthalmoscopy, Imaging systems, Detection and tracking algorithms, Reflectivity, Scanning laser ophthalmoscopes, Video, Reflectometry, Automatic tracking, Sensors

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SPIE Journal Paper | 1 January 2000 Open Access

Initial in vivo results of a hybrid retinal photocoagulation system

Cameron Wright, Steven Barrett, R. Ferguson, Henry Rylander, Ashley Welch

JBO, Vol. 5, Issue 01, (January 2000) https://doi.org/10.1117/12.10.1117/1.429969

KEYWORDS: Analog electronics, Eye, Retina, In vivo imaging, Human-machine interfaces, Laser coagulation, Mirrors, Laser therapeutics, Optical tracking, Blood vessels

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Proceedings Article | 4 October 1999 Paper

Signal processing for robotically assisted laser photocoagulation of the retina

Cameron Wright, Peter de Graaf, Steven Barrett, R. Ferguson

Proceedings Volume 3809, (1999) https://doi.org/10.1117/12.364020

KEYWORDS: Reflectivity, Retina, Analog electronics, Mirrors, Laser coagulation, Signal processing, Optical tracking, Reflectometry, Eye, Signal detection

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Proceedings Article | 26 May 1997 Paper

Hybrid retinal photocoagulation system

Cameron Wright, Steven Barrett, R. Ferguson, Henry Rylander, Ashley Welch

Proceedings Volume 2971, (1997) https://doi.org/10.1117/12.275101

KEYWORDS: Eye, Analog electronics, Retina, Confocal microscopy, Optical tracking, Reflectometry, Reflectivity, In vivo imaging, Laser coagulation, Argon ion lasers

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SPIE Journal Paper | 2 April 1997 Open Access

Hybrid approach to retinal tracking and laser aiming for photocoagulation

Cameron Wright, R. Ferguson, Henry Rylander, Ashley Welch, Steven Barrett

JBO, Vol. 2, Issue 02, (April 1997) https://doi.org/10.1117/12.10.1117/12.268964

KEYWORDS: Eye, Analog electronics, Retina, Signal detection, Mirrors, Reflectometry, Laser coagulation, Automatic tracking, Safety, Confocal microscopy

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Proceedings Article | 31 October 1996 Paper

Shadowgraphic holography of simulated space debris

Peter Nebolsine, Edmond Lo, R. Ferguson, Charles Goldey, Jeffrey Sinex, David Liquornik, Gary Hough

Proceedings Volume 2813, (1996) https://doi.org/10.1117/12.256057

KEYWORDS: Particles, Holograms, Holography, Aluminum, Epoxies, Photography, Clouds, Pulsed laser operation, Spatial resolution, 3D image reconstruction

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Proceedings Article | 17 May 1996 Paper

Hybrid tracking and control system for computer-aided retinal surgery

R. Ferguson, Cameron Wright, Henry Rylander, Ashley Welch, Steven Barrett

Proceedings Volume 2673, (1996) https://doi.org/10.1117/12.240077

KEYWORDS: Eye, Analog electronics, Retina, Reflectometry, Computing systems, Automatic tracking, Laser therapeutics, Blood vessels, Confocal microscopy, Signal detection

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Proceedings Article | 14 August 1992 Paper

Research towards development of a dynamic reflectometer for control of laser-induced retinal photocoagulation

Michael Frish, Vicky Pierce, R. Ferguson, Reginald Birngruber

Proceedings Volume 1644, (1992) https://doi.org/10.1117/12.137424

KEYWORDS: Reflectometry, Reflectivity, Eye, Laser coagulation, Retina, Eye models, Laser scattering, Light scattering, Cornea, Scattering

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Showing 5 of 35 publications

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