We present a modified colonoscope that allows for precise control over the illumination coherence, direction, and color. By capturing and processing images under different illumination conditions, this colonoscope generates maps of superficial blood flow, high spatial frequency 3D topography, reflectance, and chromophore concentrations. In this presentation, we describe the system design and characterize its contrast in benchtop experiments with various tissue phantoms. Finally, we will summarize our findings from using this multimodal imaging system on human participants undergoing colonoscopy screening.
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