The aim of this study is to identify ultrasound texture features to characterize radiation-associated acute breast toxicity in women following radiotherapy treatment for breast cancer. We investigated a series of sonographic features obtained from the gray level co-occurrence matrix (GLCM) – a second order statistical method of texture analysis. These features were tested in a pilot study of 42 postradiotherapy patients. The mean follow-up time for the postradiotherapy patients was 6 weeks. Each participant underwent an ultrasound study in which ultrasound scans were performed on the bilateral breast, generating a total of 42 post irradiation and 42 contralateral normal breasts exams. The ultrasound scans of the irradiated breasts were graded as either mild (n=27) or severe (n=15). After specifying the region of interest on the B-mode images and computing the sonographic features based off the severity grading, we observed statistically significant differences in the quantification of
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