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Such simulations enable the recreation of different clinical scenarios and identification of the minimum requirements necessary to further improve the application and develop a bedside clinical device that can potentially be used for continuous monitoring of lung function and control of ventilator settings. The potential capability of measuring non-invasively oxygen, water vapour and carbon dioxide in the lungs, would reduce the need for intubation and extracorporeal membrane oxygenation, as well as lower the incidences of chronic lung disease.
In this paper, we present results of bench-top measurements carried out in the preclinical phase of GASMAS studies. We start with a detailed explanation of the manufacturing process of multi-structure thorax phantoms with realistic geometry based on organ segmentation from anonymized DICOM images of neonates. After segmentation, the organs are 3D printed and used to create negative rubber molds. The tissue optical properties of heart, bone and muscle are assigned by mixing the silicone matrix with different concentrations of absorbers and scatters, the lung is kept as a gas content cavity and the thorax phantom is build up by placing all organs inside out immersed in the muscle structure.
The phantoms are used for quality control and validation of the system performance [4]. Oxygen gas absorption imprints are measured for different light source-detector remittance configurations and the results are used to define the potential and limitations of the GASMAS technology in the development of a bed-side clinical device.
The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases.
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