The analysis of skin lesion dermoscopic images has traditionally relied on supervised learning paradigms, necessitating extensive labeled datasets which can be costly and time-consuming for dermatologists. Conversely, the abundance of unlabeled data offers a promising avenue for self-supervised learning methods in this field. In this work, we introduce a novel strategy for hard negative synthesis that bolsters the efficacy of contrastive learning in skin lesion classification. By strategically down-weighting the contribution of the hardest negative samples during feature-level mixing, our method ensures the neural network prioritizes learning from the most informative and reliable negatives, thereby enhancing the model's feature learning ability. After fine-tuning with a limited set of labeled data, our method demonstrates notable superiority on the ISIC-2016 classification dataset, achieving a 4.29% increase in ROC AUC and a 5.39% increase in F1 score over the standard MoCo-v2 framework.
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