Dr. Valentin V. Demidov Profile

Dr. Valentin V. Demidov

Research Scientist at Dartmouth Hitchcock Medical Ctr

SPIE Involvement:

Author

Area of Expertise:

Optical Coherence Tomography , Digital Signal Processing , Radiophysics and Nonlinear Dynamics

Profile Summary

MSc - Biomedical physics, Ryerson University (Canada), 2011-2013
PhD - Medical biophysics, University of Toronto (Canada), 2013-2020
Postdoc - Biomedical engineering, Dartmouth-Hitchcock Medical Center (USA), 2019-current
CAMPEP certification - Medical Physics, Dartmouth College (USA), 2021-2022

Publications (29)

Proceedings Article | 13 March 2024 Presentation

Presentation

Comparison of the effectiveness of two different light spectra in 5-ALA-based antimicrobial photodynamic therapy of orthopaedic implant-relevant biofilms

Logan Bateman, Valentin Demidov, Natalia Demidova, Jason Gunn, Scott Sottosanti, Eric Henderson, Ida Gitajn, Jonathan Elliot

Proceedings Volume PC12822, PC128220G (2024) https://doi.org/10.1117/12.3003128

KEYWORDS: Biofilms, Photodynamic therapy, Light sources, Biomass, Visible radiation, Titanium, Tissues, Surgery, Oxygen, Optical coherence tomography

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Proceedings Article | 13 March 2024 Presentation

Presentation

Evaluating the relationship between microfractures and perfusion during osseointegration with intraoperative dynamic contrast-enhanced fluorescence imaging

Olivia Jackson, Valentin Demidov, Jason Gunn, Samuel Streeter, Jonathan Thomas Elliott, I. Leah Gitajn

Proceedings Volume PC12825, PC128250M (2024) https://doi.org/10.1117/12.3003006

KEYWORDS: Fluorescence imaging, Bone, Perfusion imaging, Biological imaging, Tomography, Surgery, Optical imaging, Ionizing radiation, Interfaces, Indocyanine green

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Proceedings Article | 13 March 2024 Presentation

Presentation

Tracking viable and dead cell clusters in melanoma after FLASH and conventional radiotherapy with optical coherence tomography

Natalia Demidova, Jason Gunn, Jonathan Elliot, Alex Vitkin, Valentin Demidov

Proceedings Volume PC12856, PC1285602 (2024) https://doi.org/10.1117/12.3003490

KEYWORDS: Skin, Radiotherapy, Optical coherence tomography, Melanoma, Tumors, Tissues, Optical tracking, Windows, Vacuum chambers, In vivo imaging

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Optical coherence tomography-based detection of orthopaedic implant biofilms formed by Methicillin-resistant S.aureus (MRSA)

V. Demidov, N. Demidova, D. Hazem, P. Craig, J. Gunn, O. Jackson, I. Gitajn, I. Vitkin, J. Elliott

Proceedings Volume 12822, 1282206 (2024) https://doi.org/10.1117/12.3001786

KEYWORDS: Biofilms, Optical coherence tomography, Metals, Histograms, Biological research, Bacteria, Scanning electron microscopy, Bioluminescence, Surgery, 3D image processing

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Proceedings Article | 13 March 2024 Poster + Paper

Poster + Paper

Development of a rabbit osseointegration prosthesis model to investigate biofilm infection and antimicrobial photodynamic therapy

Jason Gunn, Valentin Demidov, Olivia Jackson, J. Scott Sottosanti, Logan Bateman, Bailey Fearing, Joseph Hsu, Rachel Seymour, Jonathan Thomas Elliott, I. Leah Gitajn

Proceedings Volume 12822, 128220D (2024) https://doi.org/10.1117/12.3003089

KEYWORDS: Biofilms, Bioluminescence, Animals, Bacteria, Skin, Tissues, Optical coherence tomography, Biological imaging, Surgery, Bone

Read Abstract +

In orthopedic trauma surgery, traditional socket-based prostheses are associated with functionally limiting problems affecting 1.7 million amputees in the United States. To improve post-surgical performance and minimize socket-related complications, bone-anchored (osseointegrated) prostheses have been developed. Functionally superior, their widespread implementation has been limited due to infection. In an unacceptable number of patients well-organized biofilm ecosystems of bacteria colonize the osseointegrated implant (OI) and migrate into device-tissue interface, leading to superficial and deep infections, and implant failure. Since the OI implant protrudes through the skin, the site is easily contaminated by microbes. The problem is worsened by increased resistance to antibiotics contributing significantly to surgical outcome failure. Antimicrobial photodynamic therapy (aPDT)—which uses photosensitizers excited with visible light to disrupt biofilms and kill bacteria with produced reactive oxygen species—has been proposed to address this problem. To assess biofilm formation and aPDT effectiveness, we describe a rabbit OI model and steps to investigate the ability of aPDT using 5-Aminolevulinic acid (5-ALA)-based light therapy to control methicillin-resistant S. aureus (MRSA) bacterial infection. As part of an institutionally approved survival surgery, this model involves lower limb amputation at the tibia, OI installation and MRSA inoculation. Within a week of biofilm formation, the optimal aPDT regime of light and 5-ALA dose was applied to the implant-skin interface to eradicate migrating biofilms. We have built a circumferential light source spectrally shaped for optimal photoactivation and cooled without risk of bacteria dispersal. Optical coherence tomography (skin flap healing and side-effects), micro-computed tomography (OI-bone integrity) and bioluminescence (bacterial bioburden before and after aPDT) imaging were used to monitor outcome for up to three weeks post-treatment.

Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Quantification of methicillin-resistant S. aureus (MRSA) biofilm formation on orthopedic implants using bioluminescence imaging

Olivia Jackson, P. Lucas Craig, Dana Hazem, Natalia Demidova, Jason Gunn, J. Scott Sottosanti, Jonathan Thomas Elliott, Valentin Demidov, I. Leah Gitajn

Proceedings Volume 12822, 1282205 (2024) https://doi.org/10.1117/12.3001766

KEYWORDS: Bioluminescence, Biofilms, Bacteria, Titanium, Stainless steel, Standards development, In vitro testing, Microfluidics, Plating, In vivo imaging

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Proceedings Article | 13 March 2024 Presentation + Paper

Presentation + Paper

Portable red-blue light source for antimicrobial photodynamic therapy of orthopaedic implant biofilms

V. Demidov, J. Sottosanti, N. Demidova, L. Bateman, O. Jackson, P. Craig, D. Hazem, J. Gunn, I. Gitajn, J. Elliott

Proceedings Volume 12822, 1282208 (2024) https://doi.org/10.1117/12.3000416

KEYWORDS: Biofilms, Light sources, Optical coherence tomography, Bioluminescence, Light emitting diodes, Microfluidics, Titanium, Photodynamic therapy, Contamination, Tissues

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Well-organized ecosystems of bacteria colonize orthopaedic devices causing biofilm infections that are notoriously difficult to manage. Biofilms typically exhibit increased resistance to antibiotics leading to treatment failure, and tools for eradicating biofilms that do not increase antibiotic resistance are greatly needed. Antimicrobial photodynamic therapy (aPDT) is a promising form of treatment to combat clinically relevant biofilms. Exogenous provision of 5-aminolevulinic acid (5-ALA) to biofilm-forming clinical strains of E. coli, E. faecalis and S. aureus was recently shown by several research groups to result in the accumulation of sufficient quantities of endogenous photosensitizers porphyrins (protoporphyrin IX, coproporphyrin III and others), via the heme biosynthetic pathway, to produce a significant phototoxic effect when exposed to activating light. For clinical translation of this extremely promising approach, here we develop a portable light source for 5-ALA-based aPDT of orthopaedic implant biofilms, spectrally shaped for optimal porphyrin light absorption at wavelengths range approved by FDA for clinical use. After phantom calibration, we tested it on E.coli-E.faecalis biofilms grown in soft lithography-fabricated microfluidic chips and on methicillin-resistant S. aureus (MRSA) biofilms grown on titanium and stainless steel orthopaedic hardware in custom-designed macrofluidic devices. Successful in-vitro experiments allowed us to conduct a proof-of-concept validation study in a preclinical rat model of MRSA-contaminated open fracture. Following tibia fracture and two hours of wound infection development, a one hour incubation with 20% 5-ALA and treatment with either 90J/cm² or three fractions of 30J/cm² light doses demonstrated 94% and 99% overall reduction of MRSA, respectively, while the temperature of the tissue remained <39°C, below the threshold for thermal damage. The encouraging results suggest further preclinical testing of the developed light source for optimization of aPDT regimen and 5-ALA concentration to reduce the risk of long-term side effects in animal models of contaminated trauma surgery.

Proceedings Article | 15 March 2023 Presentation + Paper

Presentation + Paper

Fluorescence-guided and molecularly guided debridement: identifying devitalized and infected tissue in orthopaedic trauma

Jonathan Thomas Elliott, Eric Henderson, Samuel Streeter, Valentin Demidov, Xinyue Han, Yue Tang, J. Scott Sottosanti, Logan Bateman, Petr Brůža, Shudong Jiang, I. Leah Gitajn

Proceedings Volume 12361, 1236108 (2023) https://doi.org/10.1117/12.2661243

KEYWORDS: Tissues, Bone, Surgery, Injuries, Imaging systems, Fluorescence, Biofilms, Fluorescence imaging, Fluorescence intensity, Blood circulation

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Proceedings Article | 14 March 2023 Presentation + Paper

Presentation + Paper

Antimicrobial PDT effectively destroys E. coli and E. faecalis orthopaedic biofilms compared to low efficacy of a tobramycin and vancomycin mixture: an in vitro study using optical coherence tomography

Valentin Demidov, Matthew Bond, I. Leah Gitajn, Carey Nadell, Jonathan Elliott

Proceedings Volume 12358, 1235806 (2023) https://doi.org/10.1117/12.2654683

KEYWORDS: Biofilms, Optical coherence tomography, Vacuum chambers, Photodynamic therapy, Microfluidics, Bacteria, Mixtures, In vitro testing, Absorbance, Visualization

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SPIE Journal Paper | 12 October 2022 Open Access

Open Access

Detection and differentiation of semi-transparent materials simulating biological structures using optical coherence tomography: a phantom study

Muhammad Mohsin Qureshi, Nader Allam, Taylor Peters, Valentin Demidov, I. Alex Vitkin

JBO, Vol. 27, Issue 10, 100501, (October 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.10.100501

KEYWORDS: Lymphatic system, Optical coherence tomography, Statistical analysis, Solids, Cancer, Tissues, Speckle, In vivo imaging, Water, Transparency

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Proceedings Article | 19 May 2022 Presentation + Paper

Presentation + Paper

The effects of radiotherapy on tumour microvasculature: insights from optical coherence angiography and dynamic contrast-enhanced MR imaging towards adaptive radiation medicine

Nader Allam, W. Jeffrey Zabel, Valentin Demidov, Blake Jones, Luuk van der Pol, Warren Foltz, Costel Flueraru, Edward Taylor, I. Alex Vitkin

Proceedings Volume 12147, 121470K (2022) https://doi.org/10.1117/12.2624059

KEYWORDS: Magnetic resonance imaging, Optical coherence tomography, Radiotherapy, Angiography, Medicine, Gadolinium, Data acquisition, Oxygen, Data processing, Pre-clinical research

Read Abstract +

Stereotactic body radiotherapy (SBRT) shows promise for increasing local tumour control for many of the most lethal cancer types including pancreatic ductal carcinoma (PDA), compared to conventional radiotherapy. Yet SBRT radiation fractionation schedules may still be improved as its mechanism of action remains largely unknown. It has been suggested that this accelerated hypofractionated treatment benefits from vascular damage (in particular of blood capillaries ~10-30μm in diameter). We therefore hypothesize that monitoring radiation-induced microvascular changes will (1) yield insights into SBRT’s radiobiological effects, and (2) enable predictions of long-term tumour response. We addressed this hypothesis pre-clinically in PDA human xenografts grown in immunocompromised mice in a dorsal skinfold window chamber model. We monitored both micro- (via optical coherence tomography angiography (OCTA)) and macro- (via dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)) vascular responses to irradiation over time. We first studied responses to single fraction irradiation, and then to a full typical clinical SBRT regimen delivered via a small animal irradiator. Candidate predictive vascular biomarkers of radiobiological relevance were derived from 3D OCTA microvascular networks (micro-scale response) and correlated with the DCE-MRI functional metrics relating to the transport of an MRI contrast agent (macro-scale response). The longitudinal trajectories of both were measured before, during and following treatments. Herein we focus primarily on the DLF150 and λ metrics from OCTA which describe the microvascular heterogeneity and molecular transport efficiency. To assess the predictive power of the various metrics, their temporal trends were compared to the macroscopic tumour response (volume and viability). Efforts are ongoing to train neural networks for this time series analysis. The combined OCTA and DCE-MRI insights should yield a better understanding of tissue functional response to high doses of radiation employed in SBRT and help develop improved SBRT fractionation schedules (dose and time combinations) towards personalized and adaptive radiation therapy.

Proceedings Article | 4 March 2022 Poster + Presentation + Paper

Poster + Presentation + Paper

Validation of dynamic contrast-enhanced bone blood flow imaging technique with fluorescent microspheres

Xinyue Han, Valentin Demidov, Dennis Wirth, Brook Byrd, Scott Davis, Leah Gitajn, Jonathan Elliott

Proceedings Volume 11943, 119430H (2022) https://doi.org/10.1117/12.2608228

KEYWORDS: Fermium, Bone, Blood, Luminescence, Frequency modulation, Blood circulation, Surgery, Tissues, Imaging systems, 3D image processing

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Proceedings Article | 9 December 2021 Paper

Paper

Longitudinal in-vivo quantification of tumour microvasculature heterogeneity via optical coherence tomography (OCT) angiography in a pre-clinical model of radiation therapy

Nader Allam, W. Jeffrey Zabel, Blake Jones, Valentin Demidov, Edward Taylor, I. Alex Vitkin

Proceedings Volume 11924, 119240G (2021) https://doi.org/10.1117/12.2616024

KEYWORDS: Optical coherence tomography, Tissues, Hypoxia, In vivo imaging, Radiotherapy, Angiography, Personal digital assistants, Mode conditioning cables, Medicine, Imaging systems

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Proceedings Article | 7 December 2021 Paper

Paper

Intraoperative assessment of patient bone viability using texture analysis of dynamic contrast-enhanced fluorescence imaging

Xinyue Han, Valentin Demidov, Shudong Jiang, Ida Leah Gitajn, Jonathan Elliott

Proceedings Volume 11919, 119190A (2021) https://doi.org/10.1117/12.2614457

KEYWORDS: Luminescence, Bone, Tissues, Surgery, Binary data, Image analysis, Image quality, Image classification, Feature extraction, Principal component analysis

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

Pulsed-light illumination optical system integrated into surgical microscope for 5-ALA-induced tumor fluorescence detection without surgical process interruption

Valentin Demidov, J. Scott Sottosanti, Dennis Wirth, Linton Evans, David Roberts, Keith Paulsen, Jonathan Elliott

Proceedings Volume 11625, 116250I (2021) https://doi.org/10.1117/12.2582839

KEYWORDS: Tumors, Microscopes, Fluorescence spectroscopy, Tissues, Brain, Tissue optics, Switches, Surgery, Navigation systems, Magnetic resonance imaging

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Proceedings Article | 22 July 2019 Paper

Paper

Assessment of optical coherence tomography speckle patterns in low-scatterer-concentration regions: simulations for lymphatic vessels mapping

Lev Matveev, Alexander Matveyev, Valentin Demidov, Alexander Sovetsky, Grigory Gelikonov, Vladimir Zaitsev, I. Alex Vitkin

Proceedings Volume 11075, 1107503 (2019) https://doi.org/10.1117/12.2526749

KEYWORDS: Speckle interferometry, Speckle analysis, Speckle, Optical coherence tomography, Lymphatic system, Speckle pattern, Signal to noise ratio, Tissues, Scattering, Computer simulations, Statistical analysis

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Proceedings Article | 3 June 2019 Paper

Paper

OCT lymphangiography based on speckle statistics evaluation

Lev Matveev, Valentin Demidov, Marina Sirotkina, Dmitry Karashtin, Alexander Moiseev, Ivan Popov, Alexander Sovetsky, Alexander Matveyev, Olga Demidova, Grigory Gelikonov, Costel Flueraru, Elena Zagaynova, Natalia Gladkova, Vladimir Zaitsev, I. Alex Vitkin

Proceedings Volume 11065, 1106502 (2019) https://doi.org/10.1117/12.2523291

KEYWORDS: Speckle, Optical coherence tomography, Lymphatic system, Tissues, Tumors, Interference (communication), Signal attenuation, Angiography, Visualization, In vivo imaging

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SPIE Journal Paper | 12 October 2018 Open Access

Open Access

Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography

Valentin Demidov, Xiao Zhao, Olga Demidova, Hilary Y. M. Pang, Costel Flueraru, Fei-Fei Liu, I. Alex Vitkin

JBO, Vol. 23, Issue 10, 106003, (October 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.10.106003

KEYWORDS: Skin, Optical coherence tomography, Tissues, In vivo imaging, Tissue optics, Visualization, Capillaries, Cancer, Natural surfaces, Toxicity

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Proceedings Article | 24 May 2018 Presentation

Presentation

Pre-clinical parametric imaging for tumor delineation with optical coherence tomography (Conference Presentation)

Valentin Demidov, Dina Guryanova, Costel Flueraru, I. Alex Vitkin

Proceedings Volume 10685, 106851U (2018) https://doi.org/10.1117/12.2309744

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Image segmentation, 3D image processing, Speckle, Confocal microscopy, Luminescence, Melanoma, Skin

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Proceedings Article | 19 April 2017 Presentation

Presentation

Modeling and interpreting speckle pattern formation in swept-source optical coherence tomography (Conference Presentation)

Valentin Demidov, I. Alex Vitkin, Alexander Doronin, Igor Meglinski

Proceedings Volume 10063, 1006304 (2017) https://doi.org/10.1117/12.2253337

KEYWORDS: Optical properties, Polarization, Optical coherence tomography, Speckle pattern, Monte Carlo methods, Optical imaging, Tissues, Coherence (optics), Light scattering, Quantitative analysis

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SPIE Journal Paper | 28 July 2016 Open Access

Open Access

Microvascular contrast enhancement in optical coherence tomography using microbubbles

Homa Assadi, Valentin Demidov, Raffi Karshafian, Alexandre Douplik, I. Alex Vitkin

JBO, Vol. 21, Issue 07, 076014, (July 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.7.076014

KEYWORDS: Blood, Optical coherence tomography, Blood circulation, Tissues, Scattering, Speckle, In vivo imaging, Visualization, Particles, Ultrasonography

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SPIE Journal Paper | 14 June 2016 Open Access

Open Access

Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography

Layla Pires, Valentin Demidov, I. Alex Vitkin, Vanderlei Bagnato, Cristina Kurachi, Brian Wilson

JBO, Vol. 21, Issue 08, 081210, (June 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.8.081210

KEYWORDS: Melanoma, Tumors, Optical coherence tomography, Skin, Optical clearing, Tissues, Diffuse reflectance spectroscopy, In vivo imaging, Tissue optics, Photodynamic therapy

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Proceedings Article | 26 April 2016 Presentation

Presentation

Towards understanding speckle pattern formation in optical coherence tomography (Conference Presentation)

Valentin Demidov, Igor Meglinski, Alexander Doronin, I. Alex Vitkin

Proceedings Volume 9707, 970709 (2016) https://doi.org/10.1117/12.2214519

KEYWORDS: Optical coherence tomography, Speckle pattern, Monte Carlo methods, Polarization, Image analysis, Physics, Biomedical optics, Photonics, Current controlled current source

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Proceedings Article | 21 April 2016 Paper

Paper

Vessel-contrast enhancement in label-free optical coherence angiography based on phase and amplitude speckle variability

Lev Matveev, Valentin Demidov, Alexander Moiseev, Grigory Gelikonov, Alexandr Matveyev, Valentin Gelikonov, Maria Karabut, Ekaterina Gubarkova, Elena Finagina, Marina Sirotkina, Anna Maslennikova, Natalia Gladkova, Alex Vitkin, Vladimir Zaitsev

Proceedings Volume 9917, 99171S (2016) https://doi.org/10.1117/12.2229740

KEYWORDS: Angiography, Speckle, Image enhancement, Coherence (optics), Optical coherence tomography, Image processing, Diagnostics, Signal processing, Tissues, Binary data, Phase compensation, Signal to noise ratio

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Proceedings Article | 4 March 2016 Paper

Paper

Blood flow contrast enhancement in optical coherence tomography using microbubbles: a phantom study

Homa Assadi, Valentin Demidov, Raffi Karshafian, Alexandre Douplik, I. Alex Vitkin

Proceedings Volume 9715, 97151F (2016) https://doi.org/10.1117/12.2211665

KEYWORDS: Optical coherence tomography, Blood, Speckle, Tissues, Scattering, Blood circulation, Visualization, In vivo imaging, Gold, Particles

Read Abstract +

Proceedings Article | 20 July 2015 Paper

Paper

An approach to OCT-based microvascular imaging using reference-free processing of complex valued B-scans

Lev Matveev, Grigory Gelikonov, Alexandr Matveyev, Alexander Moiseev, Sergey Ksenofontov, Valentin Gelikonov, Marina Sirotkina, Natalia Buyanova, Natalia Gladkova, Valentin Demidov, Alex Vitkin, Vladimir Zaitsev

Proceedings Volume 9541, 954106 (2015) https://doi.org/10.1117/12.2184937

KEYWORDS: Tissues, Optical coherence tomography, Signal processing, Image filtering, Natural surfaces, Image processing, Linear filtering, Electronic filtering, Ear, Solids

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Proceedings Article | 19 March 2015 Paper

Paper

Scan-pattern and signal processing for microvasculature visualization with complex SD-OCT: tissue-motion artifacts robustness and decorrelation time - blood vessel characteristics

Lev Matveev, Vladimir Zaitsev, Grigory Gelikonov, Alexandr Matveyev, Alexander Moiseev, Sergey Ksenofontov, Valentin Gelikonov, Valentin Demidov, Alex Vitkin

Proceedings Volume 9448, 94481M (2015) https://doi.org/10.1117/12.2179246

KEYWORDS: Signal processing, Optical coherence tomography, Speckle, Tissues, Filtering (signal processing), Visualization, Linear filtering, Blood vessels, Blood, Angiography

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Proceedings Article | 26 February 2014 Paper

Paper

Imaging of electro-kinetic properties of tissue using the amplitude and the phase of optical coherence tomography

V. Toronov, V. Demidov, Y. Xu, B. Vuong, C. Sun, V. X. Yang, I. Vitkin

Proceedings Volume 8942, 89420X (2014) https://doi.org/10.1117/12.2043179

KEYWORDS: Optical coherence tomography, Tissues, Tissue optics, Algorithm development, Image processing, MATLAB, Electrodes, Fourier transforms, Smoothing, Natural surfaces

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Proceedings Article | 20 March 2013 Paper

Paper

Imaging of electro-kinetic responses of tissues with optical coherence tomography

V. Demidov, V. Toronov, Y. Xu, B. Vuong, C. Sun, V. X. Yang, A. Vitkin

Proceedings Volume 8571, 85712Q (2013) https://doi.org/10.1117/12.2005910

KEYWORDS: Optical coherence tomography, Tissues, Signal processing, Image processing, Optical fibers, Tissue optics, MATLAB, Solids, Light sources, Natural surfaces

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Showing 5 of 29 publications

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