Mr. Zhe Wei Profile

Zhe Wei

at Fujian Normal Univ

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 20 November 2024 Paper

Evaluation of the illumination system of a high-end handheld dermatoscope

Zhe Wei, Deliang Huang, Sen Wang, Shengdong Cui, Min Wang, Zheng Huang

Proceedings Volume 13242, 132420C (2024) https://doi.org/10.1117/12.3036369

KEYWORDS: Light sources and illumination, Skin, Color, Chromatic aberrations, Visualization, Light emitting diodes

Read Abstract +

Background and objectives: Dermatoscope is an important optical tool for dermatologists. Its illumination system is a key component for high quality visual observation and digital photography. The aim of this study was to evaluate the illumination system of a high-end handhold dermatoscope. Materials and Methods: DermLite DL5 was used for this study. The dermatoscope equipped with sophisticated illumination system for visualization under white, yellow and ultraviolet (UV) light with or without the use of polarization. A fiber optic spectrometer was used to measure the spectra of each lighting mode. A handhold spectrometer was used to measure the color temperature, luminance and chromatic aberration of various lighting conditions under non-polarized, cross-polarized and parallel-polarized modes. The uniformity of each lighting condition was analyzed by pixel analysis of projected digital images. Results: The peak wavelength of the UV LEDs was 377 nm and the full width at half maximum (FWHM) was 21.27 nm. The peak wavelength of the yellow LEDs was 591 nm and the FWHM was 15.5 nm. The color temperature of white LEDs was over 9000 k in several modes, whereas the color temperature of the yellow LEDs varied widely and the color temperature of mixed lighting remained stable at 5000 k. The uniformity of white, yellow and mixed lighting was less than ±10%. Conclusions: The designed higher color temperature of the tested handhold dermatoscope can accommodate the physician's view of skin blood vessels. Good uniformity under different lighting and viewing modes not only satisfies the human eye but also ensure the high quality of dermatoscope digital image of the skin.

Proceedings Article | 20 November 2024 Poster + Paper

Effect of mouse skin autofluorescence on the measurement of photosensitizer fluorescence

Xingran Guo, Weijin Peng, Zhe Wei, Shengdong Cui, Huiqi Zhan, Cheng Ke, Zheng Huang

Proceedings Volume 13242, 1324226 (2024) https://doi.org/10.1117/12.3036356

KEYWORDS: Fluorescence, Autofluorescence, Fluorescence spectroscopy, Fluorescence intensity, Tissues, Skin, Photodynamic therapy

Read Abstract +

Background: Mouse model is a unique tool for preclinical evaluation of photosensitizing drugs for their potential applications in photodynamic therapy (PDT). The fluorescent property of photosensitizer provides a useful means for in situ measurement of photosensitizer distribution. However, the autofluorescence of mouse tissues might potentially affect in situ photosensitizer fluorescence measurement. Objectives: The aim of this study was to evaluate the autofluorescence in lab mice and its influence on the in situ measurement of photosensitizer fluorescence. Materials and Materials and methods: ICR mice, commonly used lab animal model, were used. Mice were fed with regular diet and clean water. Domestically produced photosensitizing drug Hemoporfin® was used as a model sensitizer. Costume-built fluorescence imaging and spectroscope systems were used for fluorescence examination under the excitation wavelength of 400 ± 5 nm, generated from a laser or LED panel. In situ fluorescence was examined before and after i.v. injection of Hemoporfin®. Results: Epifluorescence imaging examination showed yellowish and reddish autofluorescence fluorescence in the mouth, nose, paws and tail areas. The absorption and emission spectra of mouse tissue overlaid to some degrees with that of Hemoporfin®. In situ fluorescence examination of ICR mice showed significant influence of autofluorescence on the spectral and intensity measurement of Hemoporfin® fluorescence. Such influence might be eliminated by post-measurement spectral correction algorithms. Conclusions: The autofluorescence in mouse tissues poses a significant influence on the in situ measurement of fluorescence emission of Hemoporfin®. Careful postmeasurement spectral correction is needed for accurately measuring photosensitizer fluorescence.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years