Microalbuminuria can be detected using urine protein test strips. However, this approach can only be used for qualitative analysis. Moreover, despite the high accuracy of commercial instruments for the clinical detection albumin, these devices is not suitable to be used for home detection due to their bulky size and additional labeling steps. Therefore, our study sought to develop a label-free method by three types of miniaturized detector devices (MDDs) for the detection of HSA and BSA. Using flip-chip (FC) ultraviolet-C (UV–C) light-emitting diodes (FC UVC LEDs) as a light source. The most accurate of the five tested MDDs consisted of a FC UVC LED light source, a holder, and a quartz lenses (QL1) with a light divergence angle of 16°. When detecting human serum albumin (HSA) and bovine serum albumin (BSA) at concentrations ranging from 0.01 to 4mg/mL, the coefficients of determination (R2) of absorbance and concentration at 279nm were 0.9850 and 0.9870, respectively. The FC UVC LED MDD designed herein was not only cost-effective but also had a small footprint and is therefore highly portable. The proposed approach for the quantitative detection of HSA and BSA is useful for early kidney disease screening.
In this study, a blue Micro-LED chip structure with 1-5 pairs of quantum wells was proposed, and the current-voltage (I-V) curve, electroluminescence (EL) intensity and internal quantum efficiency (IQE) were analyzed for samples with a chip size of 3.5um, respectively. The simulation results show that the IQE value is the highest when the number of pairs of quantum wells is one pair, and the IQE can reach 18% when the current density is 2A/cm2.
This study proposed 1st optical design for wide angle micro LED without 2nd lens. Micro LEDs are point light sources that the beam angle of 120°, therefore, a large number of LEDs are needed to achieve a uniform area light source. We used 1st optical design to modulate luminous intensity curve, in which micro LED as chip and through chip scale packaging (CSP) process to design wide angle micro LED that achieve full width at half maximum (FWHM) of 180°. The prototype used a square packaged that with a flip chip. Chip length, width and height of 240um, 130um and 80um respectively, the structure of wide angle micro-LEDs is including flip chip as light source, side wall around chip, a light guide layer, and a diffusion layer. The light guide layer has a great correlation with the light extraction efficiency, the diffusion layer used to control the ratio of the transmittance and reflectivity rate. We analyze the thickness of light guide layer and diffuser layer from 0.1mm to 0.4mm and 0.1mm to 0.3mm, respectively. In which the optimized package structure of thickness of light guide layer of 0.4mm, thickness of diffusion layer of 0.2mm. The prototype shows that light extraction rate of 95%, central light intensity of 25.6%, peak angle at 66° and full width at half maximum (FWHM) of 180°. This design proposed for thin, flexible, and uniform surface light source.
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