In addition to giving a good overview of diamondoids’ role in biomedicine and nanotechnology, the book is an excellent introduction to theoretical and technological aspects behind diamondoids’ chemistry, their molecular structure and physical properties. The emphasis is given to quantum calculations of diamondoids’ molecular properties. It is shown that ab-initio calculations are quite useful for the prediction of these properties, especially in light of the huge number of diamondoid molecules and their derivatives in existence. The book gives an excellent overview of quantum confinement effects and negative electron affinities of diamondoids, a unique characteristic of these molecules. It also describes the first-principles simulations of diamondoids’ interactions with other nanoscale systems, such as carbon nanotubes, metallic surfaces, and metallic atomic force microscope cantilever tips. This is an important part of the whole manuscript because those interactions are promising pathways toward an efficient design of new nanomaterials. Additionally, the book gives a good presentation of functionalized diamondoids, molecules instrumental in the creation of many nanosystems with predetermined chemical and physical properties, already applied in pharmacology and nanoelectronic devices. A careful reader of this book will learn that diamondoids are generally optically transparent in visible light and have high electrical insulating properties, as diamonds generally have. It can be grasped that many diamondoid derivatives have properties with potentially very interesting opto-electronic applications.