In Vivo 1260-nm harmonic generation microscopy of laser-induced optical breakdown in human skin

Connie Liu; Pei-Che Wu; Zi-Ping Chen; Chi-Kuang Sun; Yi-Hua Liao; Shih-Hsuan Chia

doi:10.1117/12.2646555

17 March 2023 In Vivo 1260-nm harmonic generation microscopy of laser-induced optical breakdown in human skin

Connie Liu, Pei-Che Wu, Zi-Ping Chen, Chi-Kuang Sun, Yi-Hua Liao, Shih-Hsuan Chia

Proceedings Volume PC12352, Photonics in Dermatology and Plastic Surgery 2023; PC123520K (2023) https://doi.org/10.1117/12.2646555
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Despite the effectiveness of using fractional picosecond 1064-nm Nd:YAG lasers for facial rejuvenation or resurfacing, the underlying mechanisms of the dermal remodeling with this nonablative treatment are not fully understood. We perform harmonic generation and reflectance confocal microscopy for the in vivo observation of laser-induced optical breakdown. We have found that the induced vacuoles extend to the papillary dermis using second harmonic generation imaging, which is different from the histopathology examinations and previous studies using optical coherence tomography and reflectance confocal microscopy. Our finding suggests that the fractional picosecond laser may induce collagen degeneration through suboptimal thermal effects.

Conference Presentation

Citation Download Citation

Connie Liu, Pei-Che Wu, Zi-Ping Chen, Chi-Kuang Sun, Yi-Hua Liao, and Shih-Hsuan Chia "In Vivo 1260-nm harmonic generation microscopy of laser-induced optical breakdown in human skin", Proc. SPIE PC12352, Photonics in Dermatology and Plastic Surgery 2023, PC123520K (17 March 2023); https://doi.org/10.1117/12.2646555

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Laser optics

Harmonic generation

Microscopy

Skin

In vivo imaging

Tissue optics

Optical microscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years