15 March 2023Deep-tissue volumetric microangiography with stereovision diffuse optical localization imaging (sDOLI) in the NIR-II window (Conference Presentation)
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Comprehensive evaluation of microvascular function under normal and pathological conditions requires high-resolution three-dimensional microangiography capable of providing both morphological and functional information. Herein, we propose the stereovision Diffuse Optical Localization imaging (sDOLI) approach to attain transcranial volumetric brain microangiography through triangulation and stereo-matching of images collected with two short-wave infrared cameras. The spatio-temporal sparsity of flowing microparticles allows their precise localization while minimizing structural overlaps occurring in the dual-view projections. sDOLI is shown to preserve high spatial resolution which enables transcranial mapping of murine cortical microcirculation at capillary resolution while retrieving quantitative functional information across the entire mouse cortex.
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