16 March 2023Label-free automated whole slide imaging system for histopathological assessment of tissue with total absorption photoacoustic remote sensing (Conference Presentation)
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Histological analysis is crucial for the diagnosis of a wide variety of diseases. However, labelling of thin tissue sections can alter tissue chemistry and is greatly influenced by pre-analytic variables. Furthermore, biopsies provide a limited number of tissue sections and thus stains must be used sparingly. Total Absorption Photoacoustic Remote Sensing (TA-PARS) is an all-optical and label-free technique capable of capturing both radiative and non-radiative endogenous contrasts in cells, tissues and biomolecules. Here we present an automated full-slide TA-PARS scanning system capable of providing label-free virtually stained whole slide images with sufficient resolution (~300nm) to recover subcellular diagnostic characteristics.
James Tweel,Benjamin R. Ecclestone,Marian Boktor,Kevan Bell, andParsin Haji-Reza
"Label-free automated whole slide imaging system for histopathological assessment of tissue with total absorption photoacoustic remote sensing (Conference Presentation)", Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910O (16 March 2023); https://doi.org/10.1117/12.2650201
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James Tweel, Benjamin R. Ecclestone, Marian Boktor, Kevan Bell, Parsin Haji-Reza, "Label-free automated whole slide imaging system for histopathological assessment of tissue with total absorption photoacoustic remote sensing (Conference Presentation)," Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910O (16 March 2023); https://doi.org/10.1117/12.2650201