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13 March 2024 Label-free dynamic contrast imaging of cellular activity with Powell lens-based line-field OCT (PL-LF-dOCT)
Keyu Chen, Stephanie Swanson, Julian Parkin, Saduni Sumithrarachchige, Ernest Osei, Kostadinka Bizheva
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Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC1283027 (2024) https://doi.org/10.1117/12.3005707
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Dynamic OCT (dOCT) method uses time-depended OCT signal fluctuations arising from cellular motion in biological tissues to generate additional contrast in OCT images. So far dOCT studies have been conducted with Point-scanning and Full-field dOCT platforms, each of them offering advantages and limitations such as FOV, volumetric scan and phase stability. Here we present the first line-field dOCT platform (LF-dOCT), which allows low jitter B-scan dOCT signal collections. A Powell lens is utilized for uniform line-direction system sensitivity. Various biological tissues have been imaged with the LF-dOCT platform to validate its ability to detect cellular and intracellular dynamics.
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Keyu Chen, Stephanie Swanson, Julian Parkin, Saduni Sumithrarachchige, Ernest Osei, and Kostadinka Bizheva "Label-free dynamic contrast imaging of cellular activity with Powell lens-based line-field OCT (PL-LF-dOCT)", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC1283027 (13 March 2024); https://doi.org/10.1117/12.3005707
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KEYWORDS
Optical coherence tomography
Biological imaging
Imaging systems
Spatial resolution
Tissues
Image resolution
Objectives
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