Leonardo Pioppihttps://orcid.org/0000-0002-9328-625X,1 Gustavo Jose Justo Silva,2,3 Reza Parvan,4 Marco Paolantoni,1 Alessandro Cataliotti,4 Paola Sassi5
1Department of Chemistry, Biology and Biotechnology, University of Perugia (Italy) 2Institute for Experimental Medical Research, Oslo Univ. Hospital (Norway) 3Univ. of Oslo (Norway) 4Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo (Norway) 5Univ. degli Studi di Perugia (Italy)
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Heart Failure with Preserved Ejection Fraction (HFpEF) is a severe medical condition. Concurrent pathologies linked with HFpEF create a complex scenario that contributes to structural and functional abnormalities in the heart and kidneys—the principal end organs affected by HFpEF. In this study, we assessed the effectiveness of a synergistic application of FTIR and Raman spectroscopy and multivariate/univariate statistical analyses to yield valuable pathophysiological insights in a rat model of heart failure. Peculiar biochemical differences were detected in the two organs demonstrating heightened sensitivity of these techniques towards the distinctive HFpEF phenotype.
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Leonardo Pioppi, Gustavo Jose Justo Silva, Reza Parvan, Marco Paolantoni, Alessandro Cataliotti, Paola Sassi, "Cardiorenal damage in heart failure with preserved ejection fraction: a spectroscopic study," Proc. SPIE PC13006, Biomedical Spectroscopy, Microscopy, and Imaging III, PC1300606 (20 June 2024); https://doi.org/10.1117/12.3022282