Chemical Principles In The Design Of Improved Porphyrin Photosensitizers

B. Franck; G. Fulling; M . Gosmann; G. Kniibel; H. Mertes; D. Schroder

doi:10.1117/12.960192

17 March 1989 Chemical Principles In The Design Of Improved Porphyrin Photosensitizers

B. Franck, G. Fulling, M . Gosmann, G. Kniibel, H. Mertes, D. Schroder

Proceedings Volume 0997, Advances in Photochemotherapy; (1989) https://doi.org/10.1117/12.960192
Event: O-E/Fiber LASE '88, 1988, Boston, MA, United States

Abstract

Due to the encouraging results with hematoporphyrin in photochemotherapy the porphyrin system gained predominant importance for this important medicinal application. By some convenient chemical reactions hematoporphyrin can be converted to improved derivatives, which are homogeneous, stable, and excellently soluble. Novel enlarged "porphyrinoids" with two, four, and eight additional double bonds inserted into the porphyrin ring system were synthesized. With intensive VIS absorption bands, shifted up to 300 nm to longer wave lengths compared with the normal porphyrins, these porphyrinoids may be promising for more selective and penetrating phototherapy. All the new porphyrin derivatives were shown to be efficient photosensitizers with respect to the production of singlet oxygen.

Citation Download Citation

B. Franck, G. Fulling, M . Gosmann, G. Kniibel, H. Mertes, and D. Schroder "Chemical Principles In The Design Of Improved Porphyrin Photosensitizers", Proc. SPIE 0997, Advances in Photochemotherapy, (17 March 1989); https://doi.org/10.1117/12.960192

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available